Evidence for Oxidative Stress in the Gall Bladder Mucosa of Gall Stone Patients

2002 ◽  
Vol 6 (6) ◽  
pp. 427-432 ◽  
Author(s):  
A. Geetha
Keyword(s):  
Oxidative Stress ◽  
Gall Bladder ◽  
Gall Stone ◽  
Bladder Mucosa

scholarly journals Effects of long term octreotide on gall stone formation and gall bladder function.

BMJ ◽  
1992 ◽  
Vol 304 (6842) ◽  
pp. 1611-1612 ◽  
Author(s):  
G. W. Bigg-Wither ◽  
K. K. Ho ◽  
R. R. Grunstein ◽  
C. E. Sullivan ◽  
B. D. Doust
Keyword(s):  
Gall Bladder ◽  
Stone Formation ◽  
Gall Stone ◽  
Bladder Function ◽  
Gall Stone Formation

Carbohydrate Moieties of Glycoproteins in Human Hepatic and Gall-Bladder Bile, Gall-Bladder Mucosa and Gall Stones

1979 ◽  
Vol 56 (6) ◽  
pp. 533-538 ◽  
Author(s):  
S. P. Lee ◽  
T. H. Lim ◽  
A. J. Scott
Keyword(s):  
Liquid Chromatography ◽  
Gall Bladder ◽  
Mixed Micelles ◽  
Gas Liquid Chromatography ◽  
Variable Amount ◽  
Bladder Mucosa ◽  
Human Bile ◽  
Acetylneuraminic Acid ◽  
Gall Stones ◽  
Cholesterol Solubilization

1. The soluble glycoproteins of human bile, gall-bladder mucosa and gall stones have been extracted and hydrolysed, and the monosaccharides analysed by gas-liquid chromatography. 2. Human biliary glycoproteins contained 55–75% of carbohydrate, the major monosaccharide components being galactose, fucose and N-acetylglucosamine, accounting for 70–85% of all the monosaccharides. Mannose, glucose, N-acetylgalactosamine and N-acetylneuraminic acid (sialic acid) were also present. N-Acetylneuraminic acid was present in large amounts in the gall-bladder mucosa and bile of one ulcerated and markedly inflamed gall bladder. 3. The proportion of monosaccharides in soluble glycoproteins of mucosa and bile were not different in samples from subjects with or without gall stones. 4. Gall stones were analysed for cholesterol, calcium and bilirubin and classified as ‘cholesterol stones’ (7/10) and ‘pigment stones’ (3/10). Both cholesterol and pigment stones contain a variable amount of glycoprotein. The pattern of carbohydrate constituents was similar to that present in the gall-bladder mucosa and bile in the same subject. There was also no major difference between the pattern found in ‘cholesterol’ and ‘pigment’ stones. 5. Evidence and argument are presented suggesting that some glycoprotein is secreted by the gall bladder and incorporated into gall stones. This calls for further work upon the influence of these carbohydrate-rich macromolecules on cholesterol solubilization in mixed micelles.

scholarly journals Mucin in gall bladder bile of gall stone patients: influence of treatment with chenodeoxycholic acid and ursodeoxycholic acid.

Gut ◽  
1988 ◽  
Vol 29 (11) ◽  
pp. 1506-1510 ◽  
Author(s):  
S Sahlin ◽  
A Danielsson ◽  
B Angelin ◽  
E Reihner ◽  
R Henriksson ◽  
...  
Keyword(s):  
Gall Bladder ◽  
Ursodeoxycholic Acid ◽  
Chenodeoxycholic Acid ◽  
Gall Stone

scholarly journals Evaluation of gall bladder mucosal changes in patients undergoing laparoscopic cholecystectomy

2019 ◽  
Vol 6 (11) ◽  
pp. 4108
Author(s):  
Harpreet Singh ◽  
Roop Kishan Kaul ◽  
Naveen Kumar Singh ◽  
Aviral Gupta ◽  
Vikram Singh Yadav
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Gall Bladder ◽  
Bladder Wall ◽  
Gall Stone ◽  
Granulomatous Inflammation ◽  
Stone Disease ◽  
Research Centre ◽  
Mucosal Response ◽  
Gall Bladder Wall ◽  
Mucosal Changes

Background: Histopathological changes induced by gall stone disease or cholelithiasis are diverse including acute inflammation, chronic inflammation, glandular hyperplasia, granulomatous inflammation, cholesterosis, dysplasia and carcinoma. Hence, this study was planned to assess gallbladder mucosal changes in patients undergoing laparoscopic cholecystectomy (LC) and it’s correlation with number and types of stone.Methods: A total of 50 patients with symptomatic cholelithiasis scheduled to undergo laproscopic cholecystectomy (LC) after written and informed consent from October 2015 to October 2018 at Teerthanker Mahaveer Medical College and Research Centre, Moradabad were followed prospectively. Preoperative biochemical profile and ultrasonography of whole abdomen of all the patients was obtained. LC was done under the hands of the skilled and experienced surgeons. Morphologic profile of gallstones was recorded and analysed. Gallbladder mucosal tissues were sent to general pathology department for analysis. Histopathological typing of all the gallbladder mucosal specimens was done and was correlated with the number and type of gallstones.Results: In majority (76%) cases, cholecystitis was found. Hyperplasia was seen in 10% patients. Cholecystitis with metaplasia in 10 percent of the cases and carcinoma in 2 percent of the cases. While correlating the gallbladder mucosal response with the number and type of stones, non-significant results were obtained.Conclusions: There might be some association between gall bladder mucosal changes and gall stone. We cannot say an etiologic and effective correlation from the results of this study; possible mechanism may be gall stone erodes gall bladder wall constantly over a period of time which may constitute a risk. While correlating gallbladder mucosal response with the number and type of stones, non-significant results were obtained.

scholarly journals Study on morphological changes in the gall bladder mucosa associated with cholelithiasis.

2020 ◽  
Vol 27 (08) ◽  
pp. 1753-1762
Author(s):  
Shamshad Bano ◽  
Lal Bakhsh ◽  
Gulshad Wagan ◽  
Asad Ali Zardari ◽  
Mohammad Anwar Bangulzai ◽  
...  
Keyword(s):  
Gall Bladder ◽  
Histopathological Examination ◽  
Morphological Changes ◽  
Age Groups ◽  
Morphological Type ◽  
The Body ◽  
P Value ◽  
Bladder Mucosa ◽  
Cross Sectional ◽  
Gallbladder Mucosa

Cholelithiasis is known to produce diverse histopathological changes in the gallbladder mucosa. Objectives: To observe the morphological changes in the gall bladder mucosa associated with cholelithiasis. Study Design: Descriptive Cross Sectional study. Setting: Department of Anatomy, Jamshoro with collaboration of Department of Pathology, LUMHS, Jamshoro. Period: April 2016 to October 2016. Material and Methods: All the cases after diagnosis of cholelithiasis with all age groups (20 to 50 years) in male and female were included. Gallstones were assessed for various parameters, i.e., number, size, and morphological type. Gallbladder mucosa was subjected to histopathological examination. Sections of the body, the fundus and the bottom of the gallbladder were drawn. 01 cm of the body, the body, and the bottom of the gallbladder were drawn from the funduse and prepared for histological research. Data was statistically analyzed by SPSS (Statistical Package of Social Sciences) version 22.0. Results: Total 87 cases were selected and average age of 49.95±6.14 years of male was seen in a gall bladder width and length in the gallbladder and gallbladder length in both sex of P-value 0.07 while male of female average were 41.30añ6.62, age range from 30 to 52 years. Sixty-seven (77.0%) cases had multiple stones. 29 (33.3 percent) patients had congested the serological layer, while 58 (66.7 percent) were usually impacted. Mucosa hemorrhagic in 22(25.3%) cases, atrophic in 51(58.6%) cases and nodular in 4(4.6%) cases. 36(41.4%) gall bladders reported normal results, 41(47.1%), 1(1.1%), and 3(3.4%) were identified with Fibrosis, and 2(2.3%) are found with Fibrosis. Many cases were linked to fibrosis, dysplasia, and hyperplasia, compared to single calculus (P value 0.048). There was no substantial difference between normal and thickened gall bladders in the microscopic tests (P value 0.26). Fibrosis, dysprasia and hyperplasia are correlated mainly with internal mucus detections (P value 0.002). Hemorrhagic mucous membranes are found mainly. Conclusion: Hemorrhagic and fibrotic changes were the most common mucosal findings, and significantly associated with multiple cholelithiasis.

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