Study on morphological changes in the gall bladder mucosa associated with cholelithiasis.

Cholelithiasis is known to produce diverse histopathological changes in the gallbladder mucosa. Objectives: To observe the morphological changes in the gall bladder mucosa associated with cholelithiasis. Study Design: Descriptive Cross Sectional study. Setting: Department of Anatomy, Jamshoro with collaboration of Department of Pathology, LUMHS, Jamshoro. Period: April 2016 to October 2016. Material and Methods: All the cases after diagnosis of cholelithiasis with all age groups (20 to 50 years) in male and female were included. Gallstones were assessed for various parameters, i.e., number, size, and morphological type. Gallbladder mucosa was subjected to histopathological examination. Sections of the body, the fundus and the bottom of the gallbladder were drawn. 01 cm of the body, the body, and the bottom of the gallbladder were drawn from the funduse and prepared for histological research. Data was statistically analyzed by SPSS (Statistical Package of Social Sciences) version 22.0. Results: Total 87 cases were selected and average age of 49.95±6.14 years of male was seen in a gall bladder width and length in the gallbladder and gallbladder length in both sex of P-value 0.07 while male of female average were 41.30añ6.62, age range from 30 to 52 years. Sixty-seven (77.0%) cases had multiple stones. 29 (33.3 percent) patients had congested the serological layer, while 58 (66.7 percent) were usually impacted. Mucosa hemorrhagic in 22(25.3%) cases, atrophic in 51(58.6%) cases and nodular in 4(4.6%) cases. 36(41.4%) gall bladders reported normal results, 41(47.1%), 1(1.1%), and 3(3.4%) were identified with Fibrosis, and 2(2.3%) are found with Fibrosis. Many cases were linked to fibrosis, dysplasia, and hyperplasia, compared to single calculus (P value 0.048). There was no substantial difference between normal and thickened gall bladders in the microscopic tests (P value 0.26). Fibrosis, dysprasia and hyperplasia are correlated mainly with internal mucus detections (P value 0.002). Hemorrhagic mucous membranes are found mainly. Conclusion: Hemorrhagic and fibrotic changes were the most common mucosal findings, and significantly associated with multiple cholelithiasis.

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Histopathological Evaluation of Lymph Node Biopsies: A Hospital Based Study

Journal of Enam Medical College ◽

10.3329/jemc.v2i1.11915 ◽

2012 ◽

Vol 2 (1) ◽

pp. 8-14

Author(s):

Md Atiqur Rahman ◽

Md Mamun Ali Biswas ◽

Syeda Tasfia Siddika ◽

Abdul Mannan Sikder

Keyword(s):

Lymph Node ◽

Lymph Nodes ◽

Hodgkin Lymphoma ◽

Histopathological Examination ◽

Age Groups ◽

The Body ◽

Cross Sectional ◽

Cervical Lymph Nodes ◽

Female Ratio ◽

Histopathological Evaluation

Background: Lymphadenopathy is a common manifestation of a large variety of disorders,both benign and malignant. It is essential to define the pattern of disorders presenting primarily as lymph node enlargement in a particular environment. Histopathological examination of the lymph node biopsies is a gold standard test in the distinction between reactive and malignant lymphoid proliferations as well as for detailed subtyping oflymphomas. We designed this study in our population for histopathological evaluation of lymph nodes that might be helpful for clinical management of these lesions. Objective: Histopathological evaluation of lymphadenopathy from excised specimen, in relation to ageand sex of the patients, and distribution of the lymph nodes. Materials and Methods: It was a retrospective cross sectional study conducted in the department of Pathology, Enam MedicalCollege & Hospital, Savar, Dhaka during the period from January 2006 to December 2010. Lymph node biopsies of all patients of both sexes and all age groups were included.Metastatic lymph nodes associated with evidence of primaries elsewhere in the body were excluded from the study. Total 191 lymph node biopsies were selected for histopathological evaluation. Among these 90 (47.12%) were from males and 101 (52.88%) were from females with male to female ratio being 1:2.1. The age of the patients ranged from 2 to 85 years with a mean age of 35.73 ± 18 years. Results: Cervical lymph nodes were the most common (56%) biopsied group. Of the 191 cases 59 cases (30.89%) were reactive lymphadenitis, 64 cases (33.5%) were tuberculosis, 2 cases (1.05%) were non-caseous granuloma, 11 cases (5.76%) were Hodgkin lymphoma, 22 cases (11.52%) were non-Hodgkin lymphoma, 24 cases (12.57%) were metastatic neoplasm and 9 cases (4.7%) were other lesions.Conclusion: Tuberculosis was the most common cause of lymphadenopathy, followed by reactive lymphadenitis and the cervical group of lymph nodes was most frequently affected. DOI: http://dx.doi.org/10.3329/jemc.v2i1.11915 J Enam Med Col 2012; 2(1):8 -14

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Evaluation of Cephalic Index in children from the Madheshi community in Sarlahi district, Nepal

Asian Journal of Medical Sciences ◽

10.3126/ajms.v12i10.37924 ◽

2021 ◽

Vol 12 (10) ◽

pp. 157-160

Author(s):

Surendra Kumar Sah ◽

Man Kumar Tamang ◽

Om Prakash Yadav ◽

Amit Kumar Shah

Keyword(s):

Mode Of Delivery ◽

Age Groups ◽

Significant Negative Correlation ◽

The Body ◽

P Value ◽

Cephalic Index ◽

Cross Sectional ◽

Chisquare Test ◽

Low Bmi ◽

The Mean

Background: Cephalic index is one of the important craniofacial parameters which is commonly used for investigating the length and breadth of the head. Cephalic Index (CI) is defined as the ratio between maximum breadth of the head and the maximum length of the head multiplied by 100. Body mass index (BMI) is a nutritional marker of the body derived from the measurement of height (in m2) and weight (in kg). Aims and Objective: To analyse the effect of BMI on the CI. Materials and Methods: This study was a cross-sectional study conducted from April 2021 to June 2021 with sample size of 200 children of age groups 5-8 years from Ramnagar Gaupalika of Sarlahi, Province 2, of Nepal. We measured the cephalic index of the children and asked a set of structured questionnaire to the guardian or parent of the children. Height and weight of the children were also measured and BMI was determined. Data analysis was completed using SPSS version 16. Results: The mean age of the participants was 6.56 years, BMI of 18.09 and cephalic index (CI) of 81.82. The mean CI in males and females were 82.05 and 81.59 respectively. Our results show significant association between BMI category and CI category (chisquare test, p-value=0.000), mode of delivery and BMI category (chisquare test, p=0.042) and significant negative correlation between BMI and CI (Pearson’s R=-0.591, p=0.037). Conclusion: The most common pattern of CI was hyperbrachycephalic in the children of low BMI whereas the pattern of CI in case of the normal BMI was the mesocephalic type. It also confirmed that the sexual dimorphism exists in both the low BMI and the normal BMI.

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Abstract P361: Racial/Ethnic and Age Differences in Dietary Sources of Protein, NHANES, 2011 - 2016

Circulation ◽

10.1161/circ.141.suppl_1.p361 ◽

2020 ◽

Vol 141 (Suppl_1) ◽

Author(s):

Collin J Popp ◽

Jeannette M Beasley ◽

Melanie J Firestone ◽

Rienna Russo ◽

Stella S Yi

Keyword(s):

Dietary Protein ◽

Protein Intake ◽

Age Groups ◽

The United States ◽

The Body ◽

P Value ◽

Food Category ◽

Cross Sectional ◽

Race Ethnicity ◽

Functional Components

Background: Dietary protein serves a pivotal role in providing the body with essential amino acids, which are required for the maintenance of body proteins, and the assimilation of structural and functional components required for basic survival. Understanding dietary protein sources can help inform intervention efforts to increase protein intake that will accommodate the growing diversity of the United States. Objective: The purpose of this analysis was to identify the top 10 food category sources of dietary protein by age and race and ethnicity in a nationally representative sample. Methods: Cross-sectional data on adults (18+ years) from the National Health and Nutrition Examination Survey (NHANES) 2011-2016 with one 24-hour dietary recall were analyzed (n=15,697). Population proportions were calculated for What We Eat In America food categories. Results: The analytic sample (n=15,697) was 15.0% Hispanic (95%CI [12.1, 17.9], 65.0% to non-Hispanic White (95%CI [60.8, 69.3]), 11.5% to non-Hispanic Black (95%CI [9.1, 13.9]), 5.4% to non-Hispanic Asian (95%CI [4.3, 6.6]) and 3.1% other (95%CI [2.5, 3.6]). In all racial and ethnic groups, chicken (whole pieces) was the top-ranked source of dietary protein. In addition to chicken (whole pieces), beef (excludes ground), eggs and omelets, and meat mixed dishes food categories ranked in the top ten sources of protein for every race/ethnicity. Conversely, each race/ethnicity group had at least one food category that uniquely ranked as a top ten source (other Mexican mixed dishes, cheese, burger (single code), rice, stir-fry and soy-based dishes, and nuts and seeds). Older adults consumed the least absolute protein (71 gram per day, 95% CI: [69,73]) and energy (1819 calories, 95%CI[1779, 1860] compared to other age groups (p-value for all <0.0001). Conclusion: The top ten sources of protein accounted for over 40% of dietary protein irrespective of race/ethnicity or age category, having major implications for the sustainability of our nation’s food supply. Public health strategies that encourage incorporating higher amounts of protein in food preparation have the potential to shift the overall population protein intake distribution. Funding Source: R01HL141427

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Perbedaan Penggunaan Antikoagulan K2EDTA DAN K3EDTA Terhadap Hasil Pemeriksaan Indeks Eritrosit

Jurnal Laboratorium Khatulistiwa ◽

10.30602/jlk.v1i2.147 ◽

2018 ◽

Vol 1 (2) ◽

pp. 114

Author(s):

Wahdaniah Wahdaniah ◽

Sri Tumpuk

Keyword(s):

Screening Test ◽

Venous Blood ◽

The Body ◽

Ethylene Diamine ◽

P Value ◽

Cross Sectional ◽

Significant Difference ◽

Ethylene Diamine Tetra Acetate ◽

The Difference ◽

Index Value

Abstract: Routine blood examination is the earliest blood test or screening test to determine the diagnosis of an abnormality. Blood easily froze if it is outside the body and can be prevented by the addition of anticoagulants, one of which Ethylene Diamine Tetra Acetate (EDTA). Currently available vacuum tubes containing EDTA anticoagulants in the form of K2EDTA and K3EDTA. K3EDTA is usually a salt that has better stability than other EDTA salts because it shows a pH approaching a blood pH of about 6.4. The purpose of this research is to know the difference of erythrocyte index results include MCH, MCV and MCHC using K3EDTA anticoagulant with K2EDTA. This research is a cross sectional design. This study used venous blood samples mixed with K2EDTA anticoagulant and venous blood mixed with K3EDTA anticoagulants, each of 30 samples. Data were collected and analyzed using paired different test. Based on data analysis that has been done on MCH examination, p value <0,05 then there is a significant difference between samples with K3EDTA anticoagulant with K2EDTA to erythrocyte index value. Then on the examination of MCV and MCHC obtained p value <0.05 then there is no significant difference between samples with K3EDTA anticoagulant with K2EDTA to erythrocyte index value.Abstrak: Pemeriksaan darah rutin merupakan pemeriksaan darah yang paling awal atau screening test untuk mengetahui diagnosis suatu kelainan. Darah mudah membeku jika berada diluar tubuh dan bisa dicegah dengan penambahan antikoagulan, salah satunya Ethylene Diamine Tetra Acetate (EDTA). Dewasa ini telah tersedia tabung vakum yang sudah berisi antikoagulan EDTA dalam bentuk K2EDTA dan K3EDTA. K3EDTA biasanya berupa garam yang mempunyai stabilitas yang lebih baik dari garam EDTA yang lain karena menunjukkan pH yang mendekati pH darah yaitu sekitar 6,4. Tujuan dari penelitian ini adalah untuk mengetahui perbedaan hasil indeks eritrosit meliputi MCH, MCV dan MCHC menggunakan antikoagulan K3EDTA dengan K2EDTA. Penelitian ini merupakan penelitian dengan desain cross sectional. Penelitian ini menggunakan sampel darah vena yang dicampur dengan antikoagulan K2EDTA dan darah vena yang dicampur dengan antikoagulan K3EDTA, masing-masing sebanyak 30 sampel. Data dikumpulkan dan dianalisis menggunakan uji beda berpasangan. Berdasarkan analisis data yang telah dilakukan pada pemeriksaan MCH didapatkan nilai p < 0,05 maka ada perbedaan yang signifikan antara sampel dengan antikoagulan K3EDTA dengan K2EDTA terhadap nilai indeks eritrosit. Kemudian pada pemeriksaan MCV dan MCHC didapatkan nilai p < 0,05 maka tidak ada perbedaan yang signifikan antara sampel dengan antikoagulan K3EDTA dengan K2EDTA terhadap nilai indeks eritrosit.

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The Prevalence of Insecticide Treated Net/malaria :cross section study (Preprint)

10.2196/preprints.16825 ◽

2019 ◽

Author(s):

Chanda Chalela

Keyword(s):

Study Design ◽

Age Groups ◽

Cross Sectional Study ◽

Malaria Prevalence ◽

Malaria Patient ◽

P Value ◽

Sectional Study ◽

Cross Sectional ◽

Itn Use ◽

Structured Questionnaire

BACKGROUND ABSTRACT Introduction a study on prevalence of ITN use was carried out in Buchi community Kitwe Zambia from August to October 2019 OBJECTIVE Prevalence of ITN in BUchi METHODS Methodology: This was a cross sectional study design. A structured questionnaire was used to ascertain ownership and utilization and oral interviews, 200 households were targeted 844 individual covered across the 200 households. Data was analyzed with SPSS version 23. RESULTS ABSTRACT Introduction a study on prevalence of ITN use was carried out in Buchi community Kitwe Zambia from August to October 2019 Methodology: This was a cross sectional study design. A structured questionnaire was used to ascertain ownership and utilization and oral interviews, 200 households were targeted 844 individual covered across the 200 households. Data was analyzed with SPSS version 23. Findings: household ownership of at least an ITN was 52% and individual utilization at 37.6%, with 0.825 ITN/households and 0.195ITN /individual. Malaria prevalence of 52.4% /household and a 12.4% of the population. With 47.6% malaria patient coming from households with ITN and 60% of households with ITN have insufficient coverage.61% of malaria patient were female and 31 % male. however there was no significant relation between Gender and malaria prevalence in study area (p value was >0.05). Malaria cases distribution with age groups, 0-15yrs old represented 49.5%, 16-30 yrs., was at 27.6% and the over 30 yrs. case were at 22.9% .use of other preventive measures 23% used mosquito repellent ,others methods 1% with those not using any other methods 76%. CONCLUSIONS Conclusion The study showed clearly that malaria still poses a problem .the prevalence rate of malaria was still high 12.4% of the population and 52.4% of households. With high prevalence of malaria of 49.5% for 0-15yrs.the difference between ownership 52% and Utilization 37.6% showed that even household with ITN, the ITN were not sufficient.60% of households with ITN, the ITN were not sufficient for all occupants

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The Accuracy of Broselow Tape Weight Estimate among Pediatric Population

BioMed Research International ◽

10.1155/2016/7042947 ◽

2016 ◽

Vol 2016 ◽

pp. 1-8 ◽

Cited By ~ 8

Author(s):

Turki M. AlHarbi ◽

Abdullaziz AlGarni ◽

Fasial AlGamdi ◽

Mona Jawish ◽

Tariq Ahmad Wani ◽

...

Keyword(s):

Body Weight ◽

Pediatric Population ◽

Body Height ◽

Age Groups ◽

Cross Sectional Study ◽

The Body ◽

Accurate Estimation ◽

Cross Sectional ◽

Actual Weight ◽

Medical City

Objective.To determine the accuracy of the Broselow Tape (BT) versions 2007 and 2011 in estimating weight among pediatric population.Methods.A cross-sectional study was conducted at King Fahad Medical City and six schools across Riyadh province on 1–143-month-old children. BT 2007 and 2011 estimated weights were recorded. Both tapes via the child’s height produce an estimated weight, which was compared with the actual weight.Results.A total of 3537 children were recruited. The height (cm) of the subjects was97.7±24.1and the actual weight (kg) was16.07±8.9, whereas the estimated weight determined by BT 2007 was15.87±7.56and by BT 2011 was16.38±7.95. Across all the five age groups, correlation between actual weight and BT 2007 ranged between 0.702 and 0.788, while correlation between actual weight and BT 2011 ranged between 0.698 and 0.788. Correlation between BT 2007 and BT 2011 across all the five age groups ranged from 0.979 to 0.989. Accuracy of both the tape versions was adversely affected when age was >95 months and body weight was >26 kilograms.Conclusions.Our study showed that BT 2007 and 2011 provided accurate estimation of the body weight based on measured body height. However, 2011 version provided more precise estimate for weight.

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INCIDENTAL GALL BLADDER CARCINOMA (IGBC) IN CHOLECYSTECTOMY SPECIMENS REMOVED FOR CHOLELITHIASIS

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v5i10.2258 ◽

2021 ◽

Vol 5 (10) ◽

Author(s):

Dharmpal Godara ◽

Vijay Pal Singh Dhayal

Keyword(s):

Gall Bladder ◽

Bladder Carcinoma ◽

Histopathological Examination ◽

Tertiary Hospital ◽

Cross Sectional Study ◽

Survival Outcome ◽

Sectional Study ◽

Gall Bladder Carcinoma ◽

Cross Sectional ◽

Hospital Records

Background: The present study highlights the occurrence of Incidental gallbladder carcinoma (IGBC) detected during histopathological examination in cholecystectomy specimens removed for cholelithiasis. Methods- This is a tertiary hospital based cross-sectional study of 500 cholecystectomy specimens removed during cholelithiasis. Relevant hospital records, histopathology slides and reports were reviewed, re-evaluated and studied. Results: 4(0.80%) cases of incidental gall bladder carcinoma (IGBC) were diagnosed from the histopathological evaluation (HPE) of 500 cholecystectomy specimens, constituting 0.80% of gall bladder specimens received during the study period. The age of the patients with IGBC ranged from 51-80 years. More females were affected than males with a M:F ratio of 1:3. Conclusion: Early detection of IGBC by histopathological examination would have a favourable impact on prognosis and management thereby increasing the survival outcome. Keywords: Cholelithiasis, Incidental Gall Bladder Carcinoma

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FREQUENCY OF FUNCTIONAL DISABILITY AND COGNITIVE IMPAIRMENTS IN SUB-ACUTE STROKE PATIENTS

Pakistan Journal of Rehabilitation ◽

10.36283/pjr.zu.10.2/013 ◽

2021 ◽

Vol 10 (2) ◽

pp. 69-74

Author(s):

Aisha Sarfaraz ◽

Dr Abdul Azeem ◽

Mehwish Butt ◽

Muhammad Umar

Keyword(s):

Acute Stroke ◽

Functional Disability ◽

Cognitive Impairments ◽

Age Groups ◽

Female Gender ◽

Primary Objective ◽

P Value ◽

Stroke Patients ◽

Cross Sectional Survey ◽

Cross Sectional

BACKGROUND & OBJECTIVE Stroke is a very common neurological condition affects various aspects of health. The primary objective of this study was to find out the frequency of functional disability and cognitive impairments in Sub-acute Stroke patients. MATERIAL AND METHODS A cross-sectional survey was conducted on 112 Sub-acute Stroke patients in Karachi, Pakistan. Using Barthel Index (BI) and Mini-Mental State Examination (MMSE) test was used to find out the frequency of functional disability and cognitive impairments of Sub-acute Stroke patients. RESULTS The correlation of BI scores with MMSE scores for the Male gender was 0.576 whilst the correlation of BI scores with MMSE scores for the Female gender was 0.440. The severity of functional disability concerning age groups assessed P-value was 0.026 using Chi-Square Test. The severity of functional disability (BI severity) concerning gender, P-value was found 0.097 using the same test. CONCLUSION Functional Disability is directly linked with age. However, there was no linkage established between Cognitive Impairment and age as well as gender. On close inspection, there was a trend between Functional disability and gender but not statistically significant.

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Economic implications of polypharmacy in Nepal: Multicenter community-based study

10.1101/2020.09.12.20193458 ◽

2020 ◽

Author(s):

Binaya Sapkota ◽

Suraj Shakya ◽

Saroj Sah ◽

Narendra Chaudhary ◽

Bijendra Tamang ◽

...

Keyword(s):

Drug Interactions ◽

Multinomial Logistic Regression ◽

Statistical Significance ◽

Age Groups ◽

Pharmacoeconomic Evaluation ◽

Secondary Outcome ◽

P Value ◽

Cross Sectional ◽

Economic Implications ◽

Total Cost

Objective:Improper management of polypharmacy in community and hospital pharmacies may lead to adverse effects and drug interactions in patients of all age groups, especially children and the elderly. This study aimed to determine the scenario of polypharmacy in multiple communities in Nepal and the costs associated with them. Design: Cross-sectional study Setting:Local communities of nine districts in Nepal Participants:Total 400 patients of all age groups, who were consuming medicines and who fulfilled inclusion criteria from May 2017 to August 2018 Primary and secondary outcome measures:A semi-structured questionnaire, based on the prescription optimization method, was used for data collection. Multinomial logistic regression was performed to analyze the statistical significance of polypharmacy with the predictor variables (e.g., age, education level, occupation, diagnosis, total cost of medicines). The p-value <0.05 was considered statistically significant at 95% confidence interval. Polypharmacy cases and their economic implications were reported. Results:Eighty-one patients (20.3%) with an age group of 22-31 years with female patients (219, 54.8%) reported more polypharmacy events. There were 216 patients (54%) with prescriptions of five medicines i.e., moderate polypharmacy. Total number of medicines consumed by all 400 patients was 2269, with a mean, SD 5.67, 1.08. Total expenditure by all 400 patients was USD 3409.54 during the study period, with a mean, SD 8.66, 6.04. Both moderate and severe polypharmacy cases were non-significantly related with age, gender and total cost of medications. They had significant relationship in almost all levels of education and occupation and showed mixed type of significance and non-significance with the diagnosis of the respondents. Conclusion: Polypharmacy cases can be minimized, considering adverse drug reactions and drug interactions. Further studies are warranted in medication utilization and avoidable polypharmacy along with detailed pharmacoeconomic evaluation.

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Contraception Reduces Breast Milk Protein Level of Breastfeeding Mothers in Jember, East Java, Indonesia

Health Notions ◽

10.33846/hn40504 ◽

2020 ◽

Vol 4 (5) ◽

pp. 153-157

Author(s):

Nuzula Irfa Nuriana ◽

FX. Ady Soesetijo ◽

Candra Bumi

Keyword(s):

Breast Milk ◽

Protein Level ◽

Respiratory Tract Infections ◽

Milk Protein ◽

Defense Mechanism ◽

The Body ◽

P Value ◽

Cross Sectional ◽

Tract Infections ◽

Keywords Infection

The protein level of breast milk affected the growth and development of infants. Protein has special function which is irreplaceable by other nutrients to form and protect the body cells. Protein also plays a role as antibody, functions as the body defense mechanism against various diseases and infections. Infant death in Indonesia is mostly caused by respiratory tract infections and diarrhea. Breastfeeding can help to prevent the occurrence of morbidity and mortality of infants and toddlers in which the breast milk contains many essential nutrients needed by the body, one of them is protein. The aim of this research was to analyze the effect of contraception on breast milk protein level of breastfeeding mothers in Jember regency. The design of this research was observational analytic with cross sectional approach, using statistic test of logistic regression. The result of the research showed that the effect of contraception on the protein level of breast milk obtained p-value=0.021 with Exp(B)=566.263. Based on the research, it can be concluded that there was an effect of contraception on breast milk protein level. Keywords: infection; breastmilk protein; contraception

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