A histopathological, immunohistochemical and biochemical investigation of the antidiabetic effects of the Pistacia terebinthus in diabetic rats

2020 ◽  
Vol 95 (2) ◽  
pp. 92-104
Author(s):  
A. Uyar ◽  
N. T. Abdulrahman
Keyword(s):  
Diabetic Rats ◽  
Biochemical Investigation ◽  
Pistacia Terebinthus ◽  
Antidiabetic Effects

Synergistic effect of quercetin and 6-gingerol treatment in streptozotocin induced type 2 diabetic rats and poloxamer P-407 induced hyperlipidemia

RSC Advances ◽  
2016 ◽  
Vol 6 (15) ◽  
pp. 12235-12242 ◽  
Author(s):  
Yi Shao ◽  
Yao Yu ◽  
Cheng Li ◽  
Jing Yu ◽  
Rongrong Zong ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
Diabetic Rats ◽  
Type 2 Diabetic ◽  
Antidiabetic Effects

Ginger and quercetin have been reported to have significant antidiabetic effects.

Flavonoid constituents of Amomum tsao-ko Crevost et Lemarie and its antioxidant, antidiabetic effects in diabetic rats–in vitro and in vivo studies

2021 ◽  
Author(s):  
Xiaofeng Zhang ◽  
Yujun Tang ◽  
Xiaoxian Guan ◽  
Xin Lu ◽  
Jiao Li ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Diabetic Rats ◽  
In Vivo Studies ◽  
Antidiabetic Effects

Amomum tsao-ko Crevost et Lemarie (A. tsao-ko) is a well-known dietary spice and traditional Chinese medicine. This study aimed to identify the flavonoids in A. tsao-ko and evaluate its antioxidant...

Antidiabetic Effects of Homalium letestui (Flacourtiaceae) in Streptozotocin Induced Diabetic Rats

2007 ◽  
Vol 1 (4) ◽  
pp. 134-138 ◽  
Author(s):  
Jude E. Okokon . ◽  
Bassey S. Antia . ◽  
Basil N. Ita .
Keyword(s):  
Diabetic Rats ◽  
Antidiabetic Effects

Antidiabetic effects of pterostilbene through PI3K/Akt signal pathway in high fat diet and STZ-induced diabetic rats

2019 ◽  
Vol 859 ◽  
pp. 172526 ◽  
Author(s):  
Hualei Sun ◽  
Xinxin Liu ◽  
Shao Rong Long ◽  
Teng wang ◽  
Huina Ge ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Diabetic Rats ◽  
Signal Pathway ◽  
High Fat ◽  
Antidiabetic Effects

scholarly journals α-Glucosidase Inhibitory, Anti-Oxidant, and Anti-Hyperglycemic Effects of Euphorbia nivulia–Ham. in STZ-Induced Diabetic Rats

Dose-Response ◽  
2020 ◽  
Vol 18 (3) ◽  
pp. 155932582093942
Author(s):  
Muhammad Younus ◽  
Muhammad Mohtasheem ul Hasan ◽  
Khalil Ahmad ◽  
Ali Sharif ◽  
Hafiz Muhammad Asif ◽  
...  
Keyword(s):  
High Performance ◽  
Wistar Rat ◽  
Inhibitory Effect ◽  
Diabetic Rats ◽  
In Vivo Studies ◽  
Control Group ◽  
Control Drug ◽  
Antidiabetic Effects

In this study, we aimed to investigate the antidiabetic effects of Euphorbia nivulia (En), native to Cholistan Desert area of Bahawalpur, Pakistan. First, we performed high-performance liquid chromatography analysis and found that this plant contains ferulic acid, gallic acid, quercetin, benzoic acid, polyphenols, and flavonoids. Then, we performed in vitro and in vivo studies to assess its effects on diabetic Wistar rat model. The experiments were performed and compared with control drug glibenclamide. The 70% hydroalcoholic extract of En exhibited 97.8% in vitro α-glucosidase inhibitory effect at a dose of 1.0 mg/mL. We orally administered the extract of En and control drug to the streptozotocin (STZ)-induced diabetic rats and analyzed its antidiabetic effects. We found that the extract of En with a dose of 500 mg/kg/body weight exhibited significant effect to reduce blood glucose in STZ-induced rats as compared with the control group ( P < .001). Our histological data also showed that the extract significantly improved the histopathology of pancreas. Collectively, both in vitro and in vivo studies revealed that En possesses α-glucosidase inhibitory, antioxidant, and anti-hyperglycemic effect in STZ-induced diabetic rats.

Molecular Mechanism Underlying the Antidiabetic Effects of a Siddha Polyherbal Preparation in the Liver of Type 2 Diabetic Adult Male Rats

2012 ◽  
Vol 18 (1) ◽  
pp. 29-42 ◽  
Author(s):  
Venkataraman Balaji ◽  
Jayaraman Selvaraj ◽  
Sampath Sathish ◽  
Chinnaiyan Mayilvanan ◽  
Karundevi Balasubramanian
Keyword(s):  
Insulin Receptor ◽  
Molecular Mechanism ◽  
Diabetic Rats ◽  
Male Rats ◽  
Tinospora Cordifolia ◽  
Syzygium Aromaticum ◽  
Mrna Levels ◽  
Type 2 Diabetic ◽  
Antidiabetic Effects

A siddha polyherbal preparation consisting of 5 medicinal plants, namely, Asparagus racemosus, Emblica officinalis, Salacia oblonga, Syzygium aromaticum, and Tinospora cordifolia, in equal ratio, was formulated to examine the molecular mechanism by which it exhibits antidiabetic effects in the liver of high-fat and fructose-induced type 2 diabetic rats. The polyherbal preparation treated type 2 diabetic rats showed an increase in insulin receptor, Akt, and glucose transporter2 mRNA levels compared with diabetic rats. Insulin receptor, insulin receptor substrate-2, Akt, phosphorylated Akt substrate of 160kDaThreonine642, α-Actinin-4, β-arrestin-2, and glucose transporter2 proteins were also markedly decreased in diabetic rats, whereas the polyherbal preparation treatment significantly improved the expression of these proteins more than that of metformin-treated diabetic rats. The expression pattern of insulin signaling molecules analyzed in the present study signifies the therapeutic efficacy of the siddha polyherbal preparation.

Sign in / Sign up

Export Citation Format

Share Document