Response surface methodology as optimization strategy for asymmetric bioreduction of acetophenone using whole cell of Lactobacillus senmaizukei

2019 ◽  
Vol 49 (9) ◽  
pp. 884-890 ◽  
Author(s):  
Nida Sezin Çolak ◽  
Engin Şahin ◽  
Enes Dertli ◽  
Mustafa Tahsin Yilmaz ◽  
Osman Taylan
2012 ◽  
Vol 121 ◽  
pp. 290-297 ◽  
Author(s):  
Marta Goretti ◽  
Eva Branda ◽  
Benedetta Turchetti ◽  
Maria Rita Cramarossa ◽  
Andrea Onofri ◽  
...  

Author(s):  
Changyun Zhu ◽  
Guoliang Qin

An optimization strategy called response surface methodology (RSM) is applied to a centrifugal fan impeller optimization design in this paper. RSM is used to generate an approximated model of objective function, for which a second-order polynomial function is chosen. The Design of experiment (DOE) technique coupled with CFD analysis is then ran to generate the database. The least-squares regression method (LS) is used to determine the coefficient of the RSM function. Finally, the Genetic Algorithms (GA) is applied to the objective function in order to obtain the optimal configuration. This paper also presents a solution to the problem of imprecise fitting of second-order RSM model by dividing the zone into several subzones which is proved to be effective in this paper. The optimization result shows that RSM is an effective and feasible optimization strategy for the centrifugal fan impeller design, and the complexity of the objective function and the overall optimization time could be significantly reduced.


2011 ◽  
Vol 189-193 ◽  
pp. 2851-2855
Author(s):  
Zhi Guo An ◽  
Yu Zhang

The thickness variation of drawing part is usually very complicated, which causes the accurate calculation of the surface area of drawing part to be very difficult. Blank optimization of sheet metal forming is often considered as a multi-objective problem. A blank optimization strategy of sheet metal forming process was suggested based on Response Surface Methodology (RSM). Latin Hypercube Sampling (LHS) method was introduced to design the rational experimental samples; the objective function was defined based on crack factor and wrinkle factor; the accurate response surface for sheet metal forming problem was built by Least Square Method; Genetic Algorithm (GA) was adopted in optimization and Pareto solution was selected. The strategy was applied in blank optimization of an auto-part, this method was proved suitable for blank optimization of sheet metal forming.


Author(s):  
Li Yang ◽  
Zheng Min ◽  
Sarwesh Narayan Parbat ◽  
Minking K. Chyu

In recent years, development of new manufacturing technologies like additive manufacturing has made it possible to make complex cooling structures to improve the efficiency of jet impingement. Present paper considers hybrid-linked jet impingement cooling channels which involve both parallel linked jets and serial linked jets. Systematic analysis was conducted with the aid of Computational Fluid Dynamics and Response Surface Methodology, focusing on the influence of topology on performance. An optimization platform was established with aid of the regressed database and the Genetic Algorithm. Of particular interest is the influence of optimization strategies on results. Results obtained indicates that the topology number developed in this study works well with the Response Surface Methodology. Topology can be considered to be a new degree of freedom of jet impingement design. Among the tested topologies, serial linked jet impingement has significantly higher heat transfer and pressure drop than the traditional parallel linked jet impingement. In the first optimization strategy, mass flow rate was used as the objective function while heat transfer and pressure drop were constrained. Optimized results under this strategy show consistent parameters and purely serial linked topology for all cases, due to the high cooling efficiency of serial linked jets. In the second optimization strategy, pressure drop was minimized while heat transfer and mass flow rate were constrained. Contrast with the first strategy, optimal results of this strategy have different topologies under different constraint conditions, which is caused by the complex influence of geometric parameters on pressure drop. Such results indicate the capability of hybrid-linked jet impingement to fit a wide various requirement by changing topology.


2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Elsayed Ahmed Elsayed ◽  
Nayera Ahmed Abdelwahed

Cholesterol oxidase is an alcohol oxidoreductase flavoprotein with wide biotechnological applications. The current work describes the isolation of a potential cholesterol oxidase producing streptomycete from Egyptian soil. The isolated strain produced cholesterol oxidase in submerged culture using a medium containing glucose, yeast extract, malt extract, and CaCO3 with the addition of cholesterol as an inducer. The isolated strain was identified as Streptomyces rochei NAM-19 based on 16S rRNA sequencing and phylogeny. Optimization of cholesterol oxidase production has been carried out using response surface methodology. The Plackett-Burman design method was used to evaluate the significant components of the production medium followed by Box-Behnken experimental design to locate the true optimal concentrations, which are significantly affecting enzyme production. Results showed that the predicted enzyme response could be closely correlated with the experimentally obtained production. Furthermore, the applied optimization strategy increased volumetric enzyme production by 2.55 times (65.1 U/mL) the initial production obtained before medium optimization (25.5 U/mL).


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