DETERMINATION OF THE LIPOPHILICITY PARAMETERS LOG P CALCD, RM0 AND LOG P TLC OF NEW ANTICANCER ACYLAMINOALKYL- AND SULFONYLAMINOALKYLAZAPHENOTHIAZINES BY COMPUTATIONAL METHODS AND REVERSED-PHASE THIN-LAYER CHROMATOGRAPHY

2011 ◽  
Vol 34 (5) ◽  
pp. 375-387 ◽  
Author(s):  
Beata Morak-Młodawska ◽  
Małgorzata Jeleń ◽  
Krystian Pluta
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Computational Methods ◽  
Reversed Phase ◽  
Log P ◽  
Layer Chromatography ◽  
Lipophilicity Parameters

scholarly journals Reversed-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their active metabolites

2006 ◽  
Vol 71 (6) ◽  
pp. 621-628 ◽  
Author(s):  
Jadranka Odovic ◽  
Biljana Stojimirovic ◽  
Mirjana Aleksic ◽  
Dusanka Milojkovic-Opsenica ◽  
Zivoslav Tesic
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Ace Inhibitors ◽  
Reversed Phase ◽  
Log P ◽  
Binary Solvent ◽  
Active Metabolites ◽  
Solvent Systems ◽  
Layer Chromatography ◽  
Lipophilicity Parameters

The chromatographic behaviour of some ACE inhibitors and their active metabolites was examined under conditions of reversed-phase thin-layer chromatography on RP-18 silica using water-methanol, water-ethanol and water-acetone as binary solvent systems. The relationship between the R M values and the concentration of organic modifier in the mobile phases was linear. It was found that an increase in the content of the organicmodifier in the employed solvent systems led to a decrease of the R M values, i.e., of the retention. Also, the more hydrophobic compounds had a longer retention. Based on regression analysis of the plots, the lipophilicity parameters R M 0 and c 0 were calculated. The chromatographically obtained lipophilicity parameters were correlated with the calculated log P values.

scholarly journals Reversed-phase thin-layer chromatography behavior of aldopentose derivatives

2012 ◽  
Vol 66 (3) ◽  
pp. 365-372 ◽  
Author(s):  
Dragana Livaja-Popovic ◽  
Eva Loncar ◽  
Lidija Jevric ◽  
Radomir Malbasa
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Stationary Phases ◽  
Reversed Phase ◽  
Chromatographic Behavior ◽  
Log P ◽  
Retention Factors ◽  
Mobile Phases ◽  
Acetone Water ◽  
Layer Chromatography

Quantitative structure-retention relationships (QSRR) have been used to study the chromatographic behavior of some aldopentose. The behavior of aldopentose derivatives was investigated by means of the reversed-phase thin-layer chromatography (RP TLC) on the silica gel impregnated with paraffin oil stationary phases. Binary mixtures of methanol-water, acetone-water and dioxane-water were used as mobile phases. Retention factors, RM0, corresponding to zero percent organic modifier in the aqueous mobile phase was determined. Lipophilicity C0 was calculated as the ratio of the intercept and slope values. There was satisfactory correlation between them and log P values calculated using different theoretical procedures. Some of these correlations offer very good predicting models, which are important for a better understanding of the relationships between chemical structure and retention. The study showed that the hydrophobic parameters RM0 and C0 can be used as a measures of lipophilicity of investigated compounds.

Determination of lipophilicity by means of reversed-phase thin-layer chromatography

1994 ◽  
Vol 669 (1-2) ◽  
pp. 246-253 ◽  
Author(s):  
G.L. Biagi ◽  
A.M. Barbaro ◽  
A. Sapone ◽  
M. Recanatini
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Reversed Phase ◽  
Layer Chromatography
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