TWO LIQUID CHROMATOGRAPHIC METHODS FOR THE SIMULTANEOUS DETERMINATION OF IBUPROFEN AND METHOCARBAMOL OR CHLORZOXAZONE IN THE PRESENCE OF THEIR DEGRADATION PRODUCTS

2012 ◽  
Vol 35 (7) ◽  
pp. 882-895 ◽  
Author(s):  
Ehab F. Elkady ◽  
Marwa A. Fouad
Keyword(s):  
Simultaneous Determination ◽  
Degradation Products ◽  
Chromatographic Methods ◽  
Liquid Chromatographic

scholarly journals A validated stability-indicating LC method for simultaneous determination of quinapril and hydrochlorothiazide in pharmaceutical samples

2014 ◽  
Vol 12 (4) ◽  
pp. 470-475 ◽  
Author(s):  
Marta Diego ◽  
Sigrid Mennickent ◽  
Juan Muñoz ◽  
Fernanda Sanhueza ◽  
Ricardo Godoy
Keyword(s):  
Simultaneous Determination ◽  
Degradation Products ◽  
Stability Study ◽  
Pharmaceutical Samples ◽  
Stability Indicating ◽  
Drug Substances ◽  
Liquid Chromatographic Method ◽  
The Stability ◽  
Liquid Chromatographic

AbstractA stability-indicating liquid chromatographic method was developed and validated for simultaneous determination of quinapril and hydrochlorothiazide in drug substances and dosage forms. Chromatographic separation of quinapril, hydrochlorothiazide and its degradation products was achieved on a RP-18 column, using acetonitrile and phosphate buffer (pH 4.6) as mobile phase in a gradient mode and detection at 216 nm. Stress testing was performed under hydrolytic, oxidative, thermal and photolytic conditions. The degradation products were well resolved from main peaks, proving the stability-indicating power of the method. The assay was linear for quinapril and hydrochlorothiazide concentrations of 40–200 µg mL−1 and 25–125 µg mL−1, respectively. The developed method was selective, accurate and precise for quinapril and hydrochlorothiazide determination. This method was used to quantify both drugs in combined commercial tablets. The results showed that the proposed method was found to be suitable for quantitative determination and the stability study of quinapril and hydrochlorothiazide in pharmaceutical samples.

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