Prognostic Significance of P27 and Cyclin D1 Co-Expression in Laryngeal Squamous Cell Carcinoma: Possible Target for Novel Therapeutic Strategies

2004 ◽  
Vol 16 (sup5) ◽  
pp. 3-6 ◽  
Author(s):  
E. Arisi ◽  
G. Pruneri ◽  
N. Carboni ◽  
G. Sambataro ◽  
L. Pignataro
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cyclin D1 ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Prognostic Significance ◽  
Therapeutic Strategies ◽  
Novel Therapeutic Strategies ◽  
Novel Therapeutic

Expression of cyclin D1 and Ki-67 in squamous cell carcinoma of the oral cavity: clinicopathological and prognostic significance

Oral Oncology ◽  
2002 ◽  
Vol 38 (3) ◽  
pp. 301-308 ◽  
Author(s):  
Juan Carlos de Vicente ◽  
Agustı́n Herrero-Zapatero ◽  
Manuel Florentino Fresno ◽  
Juan Sebastián López-Arranz
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Cyclin D1 ◽  
Squamous Cell ◽  
Prognostic Significance ◽  
Ki 67

scholarly journals Cyclin D1 Gene Numerical Imbalances in Laryngeal Squamous Cell Carcinoma: A Tissue Microarray Grid Based Analysis

2020 ◽  
Vol 21 (2) ◽  
pp. 379-384
Author(s):  
Efthymios Kyrodimos ◽  
Vasileios Papanikolaou ◽  
Evangelos Tsiambas ◽  
Dimitrios Kikidis ◽  
Dimitrios Peschos ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cyclin D1 ◽  
Tissue Microarray ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Grid Based

scholarly journals Prognostic Significance of Peripheral T‐Cell Subsets in Laryngeal Squamous Cell Carcinoma

2019 ◽  
Vol 4 (5) ◽  
pp. 513-519
Author(s):  
Filippo Marchi ◽  
Francesco Missale ◽  
Fabiola Incandela ◽  
Marta Filauro ◽  
Francesco Mazzola ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
T Cell ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Prognostic Significance ◽  
T Cell Subsets

Lack of Expression of Galectin-3 Is Associated With a Poor Outcome in Node-Negative Patients With Laryngeal Squamous-Cell Carcinoma

2002 ◽  
Vol 20 (18) ◽  
pp. 3850-3856 ◽  
Author(s):  
Mauro Piantelli ◽  
Stefano Iacobelli ◽  
Giovanni Almadori ◽  
Manuela Iezzi ◽  
Nicola Tinari ◽  
...  
Keyword(s):  
Overall Survival ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Univariate Analysis ◽  
Prognostic Significance ◽  
Node Negative ◽  
Increased Risk ◽  
Galectin 3

PURPOSE: Galectin-3 is a pleiotropic carbohydrate-binding protein participating in a variety of normal and pathologic processes, including cancer progression. This study was aimed at evaluating the prognostic value of galectin-3 expression in node-negative laryngeal squamous-cell carcinoma (SCC). PATIENTS AND METHODS: Galectin-3 expression was analyzed by immunohistochemistry using M3/38 monoclonal antibody, in a single-institution series of 73 node-negative laryngeal SCC patients (median follow-up, 52 months; range, 2 to 90 months). RESULTS: Forty-two (57.5%) of 73 patients expressed galectin-3. Galectin-3 expression was positively associated with tumor keratinization and histologic grade. A significant correlation was found between galectin-3 tumor positivity and longer relapse-free and overall survival. In univariate analysis, high-grade (grade 3 or 4) tumors, nonkeratinizing tumors, and galectin-3–negative tumors showed a significantly increased risk of relapse and death. In multivariate analysis, only galectin-3 expression retained an independent prognostic significance for both relapse-free and overall survival. CONCLUSION: We conclude that the absence of galectin-3 expression is an independent negative prognostic marker in laryngeal SCC patients. Thus, histochemical detection of galectin-3 in these tumors could be useful for the selection of node-negative patients with potentially unfavorable outcomes, to establish adjuvant therapy protocols.

Prognostic significance of the Ca2+ binding protein S100A2 in laryngeal squamous-cell carcinoma

2000 ◽  
Vol 89 (4) ◽  
pp. 345-349 ◽  
Author(s):  
Libero Lauriola ◽  
Fabrizio Michetti ◽  
Nicola Maggiano ◽  
Jacopo Galli ◽  
Gabriella Cadoni ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Binding Protein ◽  
Prognostic Significance

scholarly journals Prognostic significance of artemin and GFRα1 expression in laryngeal squamous cell carcinoma

2014 ◽  
Vol 8 (3) ◽  
pp. 818-822 ◽  
Author(s):  
CHAOBING GAO ◽  
XINGWANG CHENG ◽  
XIAOHONG LI ◽  
BUSHENG TONG ◽  
KAILE WU ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Prognostic Significance
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