Impact of comorbid depressive symptoms on nonverbal memory and visuospatial performance in obsessive-compulsive disorder

2003 ◽  
Vol 8 (4) ◽  
pp. 261-272 ◽  
Author(s):  
Steffen Moritz ◽  
Martin Kloss ◽  
Holger Jahn ◽  
Mildred Schick ◽  
Iver Hand
Keyword(s):  
Depressive Symptoms ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Nonverbal Memory ◽  
Compulsive Disorder

scholarly journals Mindfulness-based and acceptance-based programmes in the treatment of obsessive–compulsive disorder: a study protocol for a systematic review and meta-analysis

BMJ Open ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. e050329
Author(s):  
Johannes Julian Bürkle ◽  
Johannes Caspar Fendel ◽  
Stefan Schmidt
Keyword(s):  
Systematic Review ◽  
Depressive Symptoms ◽  
Obsessive Compulsive Disorder ◽  
Meta Analysis ◽  
Sensitivity Analyses ◽  
Secondary Outcome ◽  
Controlled Trials ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

IntroductionCognitive–behavioural therapy (CBT) with exposure and response prevention is the recommended standard for the treatment of obsessive–compulsive disorder (OCD). However, a high proportion of patients refuse this treatment, do not respond or relapse shortly after treatment. Growing evidence suggests that mindfulness-based and acceptance-based programmes (MABPs) are an effective option for the treatment of OCD. This systematic review and meta-analysis will examine the effectiveness of MABPs in treating OCD. We also aimed to explore potential moderators of the programmes’ effectiveness.Methods and analysisWe will systematically search MEDLINE, Embase, PsycINFO, PSYINDEX, Web of Science, CINAHL and Cochrane Register of Controlled Trials (no language restrictions) for studies that evaluate the effect of MABPs on patients with OCD. We will conduct backward and forward citation searches of included studies and relevant reviews and contact corresponding authors. The primary outcome will be pre-post intervention change in symptom severity. A secondary outcome will be change in depressive symptoms. Two reviewers will independently screen the records, extract the data and rate the methodological quality of the studies. We will include both controlled and uncontrolled trials. Randomised controlled trials will be meta-analysed, separately assessing between-group effects. A second meta-analysis will assess the within-group effect of all eligible studies. We will explore moderators and sources of heterogeneity such as the specific programme, study design, changes in depressive symptoms, hours of guided treatment, control condition and prior therapy (eg, CBT) using metaregression and subgroup analyses. We will perform sensitivity analyses using follow-up data. A narrative synthesis will also be pursued. We will use the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system to assess the quality of the evidence.Ethics and disseminationEthical approval is not required. Results will be published in peer-reviewed journals and presented at international conferences.

Do organizational strategies mediate nonverbal memory impairment in drug-naïve patients with obsessive-compulsive disorder?

2010 ◽  
Vol 24 (4) ◽  
pp. 527-533 ◽  
Author(s):  
Na Young Shin ◽  
Do-Hyung Kang ◽  
Jung-Seok Choi ◽  
Myung Hun Jung ◽  
Joon Hwan Jang ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Memory Impairment ◽  
Organizational Strategies ◽  
Obsessive Compulsive ◽  
Nonverbal Memory ◽  
Compulsive Disorder ◽  
Drug Naïve

Organizational strategies mediate nonverbal memory impairment in obsessive–compulsive disorder

1999 ◽  
Vol 45 (7) ◽  
pp. 905-916 ◽  
Author(s):  
Cary R Savage ◽  
Lee Baer ◽  
Nancy J Keuthen ◽  
Halle D Brown ◽  
Scott L Rauch ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Memory Impairment ◽  
Organizational Strategies ◽  
Obsessive Compulsive ◽  
Nonverbal Memory ◽  
Compulsive Disorder

Application of Cognitive-behavioral Therapy in a Case of Obsessive-compulsive Disorder

2017 ◽  
Vol 41 (S1) ◽  
pp. S644-S644
Author(s):  
L. Rodríguez Andrés ◽  
A. Rodriguez Campos ◽  
I. Sevillano Benito ◽  
H. De la Red Gallego ◽  
C. Noval Canga ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Cognitive Behavioral Therapy ◽  
Obsessive Compulsive Disorder ◽  
Behavioral Therapy ◽  
Psychiatric Inpatient ◽  
Normal Function ◽  
Cognitive Behavioral ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Competing Interest

We present the case report of a 46-year-old woman who experienced obsessive-compulsive symptoms for over twenty years, with multiple relapses, severe depressive symptoms and many hospitalizations in the psychiatric Inpatient Unit. Treatment with different SSRIs, tricyclic antidepressants, atypical antipsychotics and even electroconvulsive therapy were administered with poor results.After her last hospitalization a Cognitive-Behavioral Therapy, including exposure and response prevention and cognitive therapy, is initiated combined with medication, improving depressive symptoms, the ritual behaviors and levels of anxiety.Modern treatments for Obsessive-Compulsive Disorder (OCD) have radically changed how the disorder is viewed. While in the past OCD was regarded as chronic and untreatable, a diagnosis of OCD may now be regarded with hope. Cognitive and behavior therapy and antidepressant medications are currently used to treat the disorder. They can be used to control the symptoms and enable people with OCD to restore normal function in their lives.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Verbal and nonverbal memory processing in patients with obsessive-compulsive disorder: Its relationship to clinical variables.

2008 ◽  
Vol 22 (2) ◽  
pp. 262-272 ◽  
Author(s):  
Cinto Segalàs ◽  
Pino Alonso ◽  
Javier Labad ◽  
Nuria Jaurrieta ◽  
Eva Real ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Memory Processing ◽  
Nonverbal Memory ◽  
Compulsive Disorder ◽  
Clinical Variables

Prevalence and Associated Factors for Suicidal Ideation and Behaviors in Obsessive-Compulsive Disorder

CNS Spectrums ◽  
2007 ◽  
Vol 12 (10) ◽  
pp. 771-778 ◽  
Author(s):  
Albina Rodrigues Torres ◽  
Ana Teresa de Abreu Ramos-Cerqueira ◽  
Ricardo Cezar Torresan ◽  
Mariana de Souza Domingues ◽  
Ana Carolina R. Hercos ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Suicidal Ideation ◽  
Obsessive Compulsive Disorder ◽  
Beck Depression Inventory ◽  
Alcohol Problems ◽  
Worth Living ◽  
Obsessive Compulsive ◽  
Suicidal Thoughts ◽  
Compulsive Disorder ◽  
Suicidal Plans

ABSTRACTIntroductionPatients with obsessive-compulsive disorder (OCD) have historically been considered at low risk for suicide, but recent studies are controversial.ObjectiveTo study the prevalence of suicidal thoughts and attempts in OCD patients and to compare those with and without suicidality according to demographic and clinical variables.MethodsFifty outpatients with primary OCD (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) from a Brazilian public university were evaluated. The Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) was used to assess OCD severity, the Beck Depression Inventory to evaluate depressive symptoms and the Alcohol Use Disorders Identification Test to assess alcohol problems.ResultsAll patients had obsessions and compulsions, 64% a chronic fluctuating course and 62% a minimum Y-BOCS score of 16. Half of the patients presented relevant depressive symptoms, but only three had a history of alcohol problems. Seventy percent reported having already thought that life was not worth living, 56% had wished to be dead, 46% had suicidal ideation, 20% had made suicidal plans, and 10% had already attempted suicide. Current suicidal ideation occurred in 14% of the sample and was significantly associated with a Y-BOCS score ≥16. Previous suicidal thoughts were associated with a Beck Depression Inventory score ≥19.ConclusionSuicidality has been underestimated in OCD and should be investigated in every patient, so that appropriate preventive measures can be taken.

A Study on Sexual Function in Obsessive-Compulsive Disorder (OCD) Patients With and Without Depressive Symptoms

2016 ◽  
Vol 53 (3) ◽  
pp. 208-213 ◽  
Author(s):  
Habibollah Ghassemzadeh ◽  
Firoozeh Raisi ◽  
Reihaneh Firoozikhojastefar ◽  
Alipasha Meysamie ◽  
Narges Karamghadiri ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Sexual Function ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

scholarly journals The Immediate Effect of COVID-19 Pandemic on Children and Adolescents with Obsessive Compulsive Disorder

2020 ◽  
Author(s):  
Judith Becker Nissen ◽  
David Højgaard ◽  
Per Hove Thomsen
Keyword(s):  
Depressive Symptoms ◽  
Family History ◽  
Psychiatric Disorders ◽  
Obsessive Compulsive Disorder ◽  
Age Of Onset ◽  
Close Contact ◽  
Clinical Group ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
History Of

Abstract Background Obsessive compulsive disorder (OCD) is a distressing psychiatric disorder. Traumas may trigger or aggravate OCD symptoms. COVID-19 pandemic has coursed a global crisis and has been associated with onset of psychiatric disorders in adults. Little is known about children/adolescents with OCD. The present study aimed to examine how children/adolescents with OCD react towards COVID-19 crisis. Methods A questionnaire was distributed to two separate groups of children/adolescents. One group was a clinical group newly diagnosed at a specialized OCD clinic. All the children/adolescents had a current close contact to a therapist or doctor. The other group was a survey group identified through the Danish OCD Association. Most of these children/adolescents were diagnosed years ago, and their primary treatment was completed. For the clinical group, data from patient files was available. Results In both groups, but most pronounced in the survey group, participants experienced a worsening of their OCD, anxiety, and depressive symptoms. The aggravation of OCD correlated with the worsening of anxiety, depressive symptoms, and the extent of avoidance behavior. For both groups, OCD aggressive symptoms predicted a significant worsening. Poor baseline insight showed a trend to predict a symptom worsening. The worsening was most pronounced in children with early age of onset and a family history of attention deficit hyperactivity disorder. Conclusions To our knowledge, this is one of the first studies examining the effect of COVID-19 in children/adolescents with OCD. The effect was examined in two separate populations strengthening the findings. The study points towards an influence of the OCD phenotype, baseline insight suggesting a continued vulnerability, and a family history of psychiatric disorders. Trial registration The study is approved by the Danish Data Protection Agency (1-16-02-147-20) registered 1 st of April 2020. Oral and written information was given to parents and patients and written consent from patients over 15 years and parents were received.

Clomipramine versus Phenelzine in Obsessive–Compulsive Disorder

1992 ◽  
Vol 161 (5) ◽  
pp. 665-670 ◽  
Author(s):  
J. Vallejo ◽  
J. Olivares ◽  
T. Marcos ◽  
A. Bulbena ◽  
J. M. Menchón
Keyword(s):  
Clinical Trial ◽  
Depressive Symptoms ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Double Blind ◽  
Compulsive Disorder ◽  
Double Blind Clinical Trial ◽  
Significant Difference

A double-blind clinical trial of clomipramine versus phenelzine was carried out on 30 patients suffering from DSM–III obsessive–compulsive disorder. The study period was 12 weeks, and the maximum doses used (from the fifth week on) were 225 mg/day for clomipramine (14 patients) and 75 mg/day for phenelzine (12 patients); four patients dropped out. Obsessive symptoms improved significantly in both drug groups, but there was no significant difference between groups. Depressive symptoms improved before obsessive ones.

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