Serum levels of the extracellular domain of the epidermal growth factor receptor in individuals exposed to arsenic in drinking water in Bangladesh

Biomarkers ◽  
2007 ◽  
Vol 12 (3) ◽  
pp. 256-265 ◽  
Author(s):  
Y. Li ◽  
Y. Chen ◽  
V. Slavkovic ◽  
H. Ahsan ◽  
F. Parvez ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Drinking Water ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Serum Levels ◽  
Extracellular Domain ◽  
Epidermal Growth

scholarly journals A point mutation in the extracellular domain activates LET-23, the Caenorhabditis elegans epidermal growth factor receptor homolog.

1996 ◽  
Vol 16 (2) ◽  
pp. 529-537 ◽  
Author(s):  
W S Katz ◽  
G M Lesa ◽  
D Yannoukakos ◽  
T R Clandinin ◽  
J Schlessinger ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Caenorhabditis Elegans ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Point Mutation ◽  
Growth Factor Receptor ◽  
Extracellular Domain ◽  
Cysteine Residue ◽  
Loss Of Function ◽  
Epidermal Growth

The let-23 gene encodes a Caenorhabditis elegans homolog of the epidermal growth factor receptor (EGFR) necessary for vulval development. We have characterized a mutation of let-23 that activates the receptor and downstream signal transduction, leading to excess vulval differentiation. This mutation alters a conserved cysteine residue in the extracellular domain and is the first such point mutation in the EGFR subfamily of tyrosine kinases. Mutation of a different cysteine in the same subdomain causes a strong loss-of-function phenotype, suggesting that cysteines in this region are important for function and nonequivalent. Vulval precursor cells can generate either of two subsets of vulval cells (distinct fates) in response to sa62 activity. The fates produced depended on the copy number of the mutation, suggesting that quantitative differences in receptor activity influence the decision between these two fates.

scholarly journals Interaction of the Extracellular Domain of the Epidermal Growth Factor Receptor with Gangliosides

2002 ◽  
Vol 277 (12) ◽  
pp. 10108-10113 ◽  
Author(s):  
Erik A. Miljan ◽  
Emmanuelle J. Meuillet ◽  
Barbara Mania-Farnell ◽  
David George ◽  
Hirotaka Yamamoto ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Extracellular Domain ◽  
Epidermal Growth
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