scholarly journals The interaction between microbiome and host central nervous system: the gut-brain axis as a potential new therapeutic target in the treatment of obesity and cardiometabolic disease

2020 ◽  
Vol 24 (7) ◽  
pp. 639-653
Author(s):  
Madelief Wijdeveld ◽  
Max Nieuwdorp ◽  
Richard IJzerman
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Therapeutic Target ◽  
Cardiometabolic Disease ◽  
Treatment Of Obesity

Adipocytes-released Peptides Involved in the Control of Gastrointestinal Motility

2019 ◽  
Vol 20 (6) ◽  
pp. 614-629 ◽  
Author(s):  
Eglantina Idrizaj ◽  
Rachele Garella ◽  
Roberta Squecco ◽  
Maria Caterina Baccari
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Adipose Tissue ◽  
Gastrointestinal Motility ◽  
Diagnostic Tools ◽  
Therapeutic Approaches ◽  
Motor Responses ◽  
Gastrointestinal Motor ◽  
Treatment Of Obesity ◽  
Novel Therapeutic

The present review focuses on adipocytes-released peptides known to be involved in the control of gastrointestinal motility, acting both centrally and peripherally. Thus, four peptides have been taken into account: leptin, adiponectin, nesfatin-1, and apelin. The discussion of the related physiological or pathophysiological roles, based on the most recent findings, is intended to underlie the close interactions among adipose tissue, central nervous system, and gastrointestinal tract. The better understanding of this complex network, as gastrointestinal motor responses represent peripheral signals involved in the regulation of food intake through the gut-brain axis, may also furnish a cue for the development of either novel therapeutic approaches in the treatment of obesity and eating disorders or potential diagnostic tools.

scholarly journals Microglia as therapeutic target in central nervous system disorders

2020 ◽  
Vol 144 (3) ◽  
pp. 102-118
Author(s):  
Oluwaseun Fatoba ◽  
Takahide Itokazu ◽  
Toshihide Yamashita
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Therapeutic Target ◽  
Central Nervous System Disorders

scholarly journals B7–H3 as a Prognostic Biomarker and Therapeutic Target in Pediatric central nervous system Tumors

2020 ◽  
Vol 13 (2) ◽  
pp. 365-371 ◽  
Author(s):  
Uday B. Maachani ◽  
Umberto Tosi ◽  
David J. Pisapia ◽  
Sushmita Mukherjee ◽  
Christopher S. Marnell ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Therapeutic Target ◽  
Prognostic Biomarker ◽  
Central Nervous System Tumors ◽  
Nervous System Tumors
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