scholarly journals Design, synthesis, and biological evaluation of new thieno[2,3-d] pyrimidine derivatives as targeted therapy for PI3K with molecular modelling study

2021 ◽  
Vol 37 (1) ◽  
pp. 315-332
Author(s):  
Fatma M. Elmenier ◽  
Deena S. Lasheen ◽  
Khaled A. M. Abouzid
Keyword(s):  
Targeted Therapy ◽  
Molecular Modelling ◽  
Biological Evaluation ◽  
Pyrimidine Derivatives ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Modelling Study

Pyrrolo[2,3-d]pyrimidine derivatives as inhibitors of RET: Design, synthesis and biological evaluation

2020 ◽  
Vol 206 ◽  
pp. 112691
Author(s):  
Naga Rajiv Lakkaniga ◽  
Naresh Gunaganti ◽  
Lingtian Zhang ◽  
Binyam Belachew ◽  
Brendan Frett ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Pyrimidine Derivatives ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Design, synthesis and biological evaluation of aryl pyrimidine derivatives as potential leishmanicidal agents

2013 ◽  
Vol 23 (18) ◽  
pp. 5235-5238 ◽  
Author(s):  
S.N. Suryawanshi ◽  
Santosh Kumar ◽  
Rahul Shivahare ◽  
Susmita Pandey ◽  
Avinash Tiwari ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Pyrimidine Derivatives ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

ChemInform Abstract: Design, Synthesis and Biological Evaluation of Aryl Pyrimidine Derivatives as Potential Leishmanicidal Agents.

ChemInform ◽  
2014 ◽  
Vol 45 (4) ◽  
pp. no-no
Author(s):  
S. N. Suryawanshi ◽  
Santosh Kumar ◽  
Rahul Shivahare ◽  
Susmita Pandey ◽  
Avinash Tiwari ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Pyrimidine Derivatives ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis, and biological evaluation of new thiazolo[5,4-d]pyrimidine derivatives as potent antiproliferative agents

MedChemComm ◽  
2017 ◽  
Vol 8 (8) ◽  
pp. 1655-1658 ◽  
Author(s):  
Zhong-Hua Li ◽  
Xue-Qi Liu ◽  
Peng-Fei Geng ◽  
Jin-Lian Ma ◽  
Tao-Qian Zhao ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Pyrimidine Derivative ◽  
Pyrimidine Derivatives ◽  
Design Synthesis ◽  
Antiproliferative Agents ◽  
Potent Inhibition ◽  
Synthesis And Biological Evaluation

The thiazolo[5,4-d]pyrimidine derivative 7i exhibited potent inhibition against MGC-803 and HGC-27 with IC50 values of 4.64 and 5.07 μM, respectively and around 12-fold selectivity between MGC-803 and GES-1.

Design, Synthesis, and Biological Evaluation of Some Cyclohepta[b]Thiophene and Substituted Pentahydrocycloheptathieno[2,3-d]Pyrimidine Derivatives

2016 ◽  
Vol 54 (2) ◽  
pp. 1084-1093 ◽  
Author(s):  
Elshaymaa I. Elmongy ◽  
Mohammed A. Khedr ◽  
Nageh A. Taleb ◽  
Hanem M. Awad ◽  
Safinaz E.-S. Abbas
Keyword(s):  
Biological Evaluation ◽  
Pyrimidine Derivatives ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation
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