scholarly journals A new phenolic derivative with soluble epoxide hydrolase and nuclear factor-kappaB inhibitory activity from the aqueous extract of Acacia catechu

2015 ◽  
Vol 30 (18) ◽  
pp. 2085-2092 ◽  
Author(s):  
Ya Nan Sun ◽  
Wei Li ◽  
Seok Bean Song ◽  
Xi Tao Yan ◽  
Yan Zhao ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Inhibitory Activity ◽  
Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase ◽  
Nuclear Factor Kappab ◽  
Nuclear Factor ◽  
Phenolic Derivative ◽  
Acacia Catechu

scholarly journals IN VITRO SOLUBLE EPOXIDE HYDROLASE ENZYME INHIBITORY ACTIVITY OF SOME NOVEL CHALCONE DERIVATIVES

2012 ◽  
Vol 2 (4) ◽  
Author(s):  
Kuppusamy Asokkumar ◽  
Lokeswari Prathyusha Tangella ◽  
Muthusamy Umamaheshwari ◽  
Thirumalaisamy Shivashanmugam ◽  
Varadharajan Subhadradevi ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase ◽  
Chalcone Derivatives

Chemical components from the seeds of Catalpa bungei and their inhibitions of soluble epoxide hydrolase, cholinesterase and nuclear factor kappa B activities

RSC Advances ◽  
2016 ◽  
Vol 6 (47) ◽  
pp. 40706-40716 ◽  
Author(s):  
Hao-Yu Tang ◽  
Meng-Meng Bai ◽  
Jun-Mian Tian ◽  
Gennaro Pescitelli ◽  
Trpimir Ivšić ◽  
...  
Keyword(s):  
Epoxide Hydrolase ◽  
Nuclear Factor Kappa B ◽  
Soluble Epoxide Hydrolase ◽  
Chemical Components ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Catalpa Bungei

22 compounds, including two rare cage chlorinated iridoids, bungosides A (1) and B (2), were isolated fromCatalpa bungei. of soluble epoxide hydrolase (sEH), acetylcholinesterase (AChE) and BChE, and NF-κB activity.

A new bibenzyl derivative with nuclear factor-kappaB inhibitory activity fromSchefflera arboricola(Araliaceae)

2014 ◽  
Vol 29 (12) ◽  
pp. 1139-1144 ◽  
Author(s):  
Hang Li ◽  
Zi-Zhe Cai ◽  
Long-Ping Zhu ◽  
Xin-Jun Xu ◽  
Shao-Rui Chen ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Nuclear Factor Kappab ◽  
Nuclear Factor

Soluble epoxide hydrolase inhibitory activity of anthraquinone components from Aloe

2015 ◽  
Vol 23 (20) ◽  
pp. 6659-6665 ◽  
Author(s):  
Ya Nan Sun ◽  
Jang Hoon Kim ◽  
Wei Li ◽  
A. Reum Jo ◽  
Xi Tao Yan ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase

scholarly journals Attenuation of Cisplatin-Induced Renal Injury by Inhibition of Soluble Epoxide Hydrolase Involves Nuclear Factor κB Signaling

2012 ◽  
Vol 341 (3) ◽  
pp. 725-734 ◽  
Author(s):  
Yingmei Liu ◽  
Heather K. Webb ◽  
Hisayo Fukushima ◽  
Janine Micheli ◽  
Svetlana Markova ◽  
...  
Keyword(s):  
Renal Injury ◽  
Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase ◽  
Nuclear Factor Κb ◽  
Nuclear Factor

Soluble epoxide hydrolase inhibitory activity of anthraquinone components from Aloe

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
YN Sun ◽  
AR Jo ◽  
JH Kim ◽  
JS Kang ◽  
YH Kim
Keyword(s):  
Inhibitory Activity ◽  
Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase

scholarly journals Soluble Epoxide Hydrolase Inhibitory Activity of Components Isolated from Apios americana Medik

Molecules ◽  
2017 ◽  
Vol 22 (9) ◽  
pp. 1432 ◽  
Author(s):  
Jang Kim ◽  
Hyo Kim ◽  
Si Kang ◽  
Young Kim ◽  
Chang Jin
Keyword(s):  
Inhibitory Activity ◽  
Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase ◽  
Apios Americana

scholarly journals Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo

2009 ◽  
Vol 8 (8) ◽  
pp. 2193-2203 ◽  
Author(s):  
Jun-Yan Liu ◽  
See-Hyoung Park ◽  
Christophe Morisseau ◽  
Sung Hee Hwang ◽  
Bruce D. Hammock ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase

scholarly journals 2-(Piperidin-4-yl)acetamides as Potent Inhibitors of Soluble Epoxide Hydrolase with Anti-Inflammatory Activity

2021 ◽  
Vol 14 (12) ◽  
pp. 1323
Author(s):  
Juan Martín-López ◽  
Sandra Codony ◽  
Clara Bartra ◽  
Christophe Morisseau ◽  
María Isabel Loza ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Epoxide Hydrolase ◽  
Inflammatory Diseases ◽  
Soluble Epoxide Hydrolase ◽  
Inflammatory Activity ◽  
Epoxyeicosatrienoic Acids ◽  
Pharmacological Inhibition ◽  
Anti Inflammatory ◽  
Further Development ◽  
Potent Inhibitory Activity

The pharmacological inhibition of soluble epoxide hydrolase (sEH) has been suggested as a potential therapy for the treatment of pain and inflammatory diseases through the stabilization of endogenous epoxyeicosatrienoic acids. Numerous potent sEH inhibitors (sEHI) have been developed, however many contain highly lipophilic substituents limiting their availability. Recently, a new series of benzohomoadamantane-based ureas endowed with potent inhibitory activity for the human and murine sEH was reported. However, their very low microsomal stability prevented further development. Herein, a new series of benzohomoadamantane-based amides were synthetized, fully characterized, and evaluated as sEHI. Most of these amides were endowed with excellent inhibitory potencies. A selected compound displayed anti-inflammatory effects with higher effectiveness than the reference sEHI, TPPU.

Sign in / Sign up

Export Citation Format

Share Document