Dewerin and gilbertionol two new secondary metabolites from the stem bark of Gilbertiodendron dewevrei (De Wild) J. Leonard

Abstract Two new pentacyclic triterpenes 8,26-cyclo-urs-21-en-3β, 20β-diol (1) and 3β-acetoxy-8.26- cyclo-ursan-20β-ol (2) together with 3-friedelanone, oleanolic acid, betulinic acid, lupeol acetate, α- and β-amyrine, S.SJ^'-tetrahydroxyflavane, and 3,5,7,3',4'-pentahydroxyflavane were isolated from the stem bark of Ficus cordata (Moraceae). The structures of these secondary metabolites were established using ID and 2D NMR spectra and by comparison with published data or with authentic samples. Compounds 1 and 2 exhibited weak antibacterial and no antifungal activity.

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Senegalin, a new phenylpropanoid and other secondary metabolites from the stem bark of Ekebergia senegalensis A. Juss. (Meliaceae)

Natural Product Research ◽

10.1080/14786419.2020.1729151 ◽

2020 ◽

pp. 1-7

Author(s):

Guy Paulin M. Kemayou ◽

Gervais M. Happi ◽

Yvan Anderson T. Ngandjui ◽

Jean Claude Tchouankeu ◽

Norbert Sewald ◽

...

Keyword(s):

Secondary Metabolites ◽

Stem Bark

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Secondary Metabolites from Teclea amanuensis (Rutaceae) from Tanzania

Natural Product Communications ◽

10.1177/1934578x0800301020 ◽

2008 ◽

Vol 3 (10) ◽

pp. 1934578X0800301

Author(s):

Joseph J. Magadula ◽

Modest C Kapingu ◽

Zakaria H. Mbwambo ◽

Dulcie A. Mulholland

Keyword(s):

Secondary Metabolites ◽

Stem Bark ◽

Lupeol Acetate ◽

Isolated Structures ◽

Acridone Alkaloid ◽

New Compounds

The dichloromethane extract of the stem bark of Teclea amaniensis has yielded two novel furoquinoline alkaloids, 5-[3-methylbut-2-enyl]-4,6,7-trimethoxyfuro[2,3- b]quinoline and 6-(2′,3′-epoxy-3-methylbutyl)-5-hydroxyl-4,7-dimethoxyfuro[2,3- b]quinoline, in addition to an acridone alkaloid, 2-hydroxy-1,3-dimethoxy-10-methylacridone. Three known alkaloids, dictamnine, kokusaginine and evoxanthine, and two known triterpenoids, lupeol and lupeol acetate were also isolated. Structures of the new compounds were established by means of NMR spectroscopic and MS data.

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A New Bianthracene C-arabinopyranoside from Senna septemtrionalis

Natural Product Communications ◽

10.1177/1934578x1000500514 ◽

2010 ◽

Vol 5 (5) ◽

pp. 1934578X1000500

Author(s):

Gizachew Alemayehu ◽

Legesse Adane ◽

Berhanu M. Abegaz

Keyword(s):

Secondary Metabolites ◽

Nmr Spectra ◽

Spectroscopic Analysis ◽

Stem Bark ◽

The Novel

Chrysophanol, physcion, emodin, floribundone-1, 5,7′-physcion-fallacinol, and the novel 5,7′-physcion-physcion-10′- C-α-arabinopyranoside were isolated from the stem bark of Senna septemtrionalis. The structures of these secondary metabolites were determined on the basis of spectroscopic analysis, especially from NMR spectra in conjunction with COSY, HMQC, HMBC and TOCSY.

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Chemical constituents of the stem bark of Acacia AuriculiformisA.Cunn ex. Benth. (fabaceae)

Nigerian Journal of Natural Products and Medicine ◽

10.4314/njnpm.v23i1.12 ◽

2020 ◽

Vol 23 ◽

pp. 88-91

Author(s):

A.A. Ahmadu ◽

B.A. Lawal ◽

B. Olanipekun ◽

A. Udobre ◽

N. Tsafantakis ◽

...

Keyword(s):

Mass Spectrometry ◽

Secondary Metabolites ◽

Acid Ester ◽

Spectroscopic Analysis ◽

Chemical Constituents ◽

Stem Bark ◽

Acacia Auriculiformis ◽

Compound I ◽

Literature Report ◽

First Time

The genus Acacia has been known to be a rich source of many secondary metabolites. This study was carried to isolate chemical constituents present in the stem bark of Acacia auriculiformis. The dichloromethane extract of the stem bark of Acacia auriculiformis was obtained by maceration. The extract obtained was subjected to silica gel column chromatography and preparative TLC. The isolated compounds were identified by spectroscopic analysis. This led to the isolation of ferulic acid ester (I), along with a steroid (II) and a triterpenoid (III). The structure of compound I was established using spectroscopic analysis (UV, IR, NMR and mass spectrometry) and identified to be dodecyl-4-hydroxy-3-methoxy-trans-cinnamate (I), compounds II and III were found to be á-spinasterol and lupenol respectively, based on the comparison of their spectral data NMR and MS with literature report. Compound I is being reported for the first time in the genus Acacia.

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Secondary Metabolites and Cytotoxic Activities from the Stem Bark ofZanthoxylum nitidum

Chemistry & Biodiversity ◽

10.1002/cbdv.200800107 ◽

2009 ◽

Vol 6 (6) ◽

pp. 846-857 ◽

Cited By ~ 32

Author(s):

Cheng-Hui Yang ◽

Ming-Jen Cheng ◽

Shiow-Ju Lee ◽

Cheng-Wei Yang ◽

Hsun-Shuo Chang ◽

...

Keyword(s):

Secondary Metabolites ◽

Stem Bark ◽

Cytotoxic Activities

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ChemInform Abstract: Secondary Metabolites from the Stem Bark of Litsea akoensis and Their Cytotoxic Activity.

ChemInform ◽

10.1002/chin.200843199 ◽

2008 ◽

Vol 39 (43) ◽

Author(s):

Su-Yen Chang ◽

Ming-Jen Cheng ◽

Yueh-Hsiung Kuo ◽

Shiow-Ju Lee ◽

Hsun-Shuo Chang ◽

...

Keyword(s):

Secondary Metabolites ◽

Cytotoxic Activity ◽

Stem Bark

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Virtual Screening in Pharmacokinetics, Bioactivity, and Toxicity of the Amburana cearensis Secondary Metabolites

Biointerface Research in Applied Chemistry ◽

10.33263/briac126.84718491 ◽

2021 ◽

Vol 12 (6) ◽

pp. 8471-8491

Keyword(s):

Secondary Metabolites ◽

Phenolic Acids ◽

Stem Bark ◽

New Drugs ◽

Structure Property ◽

In Vivo Models ◽

Popular Medicine ◽

Anti Inflammatory

Bioprospecting has contributed to the work of pharmaceutical chemists in the development and commercial disposal of new drugs. Currently, the pharmaceutical industry has emphasized drugs produced from bioactive compounds extracted from natural sources, based on popular medicine discussed in the literature, such as secondary metabolites isolated from the stem bark and seeds of the Amburana cearensis, rich in coumarin derivatives, flavonoids, and phenolic acids and is popularly used in the treatment of respiratory diseases and with anti-inflammatory and antioxidant bioactivity. This review is a study of the structure/activity and structure/property (SAR/SPA) relationship with the physicochemical properties calculated by the algorithms of the MarvinSketch software for the secondary metabolites of A. cearensis, as well as their correlation with in silico test values the SwissADME and admetSAR 2.0 servers and in vitro and in vivo models of the dataset from the PreADMET, GUSAR Online and PASS Online servers. The results showed that substances derived from coumarin, flavonoids, and phenolic acids have attributes of good permeability and low efflux, which favor their oral bioavailability, since phenolic heterosides, amburoside analogs, and biflavonoids are effective in local action as subcutaneous application, constituting promising antimicrobial, anti-inflammatory and antioxidant therapeutic actions in their proper administration routes.

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Pengaruh Antibakteri Ekstrak Kulit Batang Matoa (Pometia pinnata) terhadap Bakteri Staphylococcus aureus secara In vitro

Jurnal MIPA ◽

10.35799/jm.2.2.2013.3121 ◽

2013 ◽

Vol 2 (2) ◽

pp. 128 ◽

Cited By ~ 2

Author(s):

Mercy Ngajow ◽

Jemmy Abidjulu ◽

Vanda S. Kamu

Keyword(s):

Staphylococcus Aureus ◽

Secondary Metabolites ◽

Antibacterial Effect ◽

Inhibition Zone ◽

Stem Bark ◽

Positive Control ◽

Negative Control ◽

Bark Extract ◽

Distilled Water

Telah dilakukan penelitian secara kualitatif terhadap pengaruh antibakteri dari ekstrak kulit batang matoa (Pometia pinnata. Spp.) terhadap bakteri Gram positif Staphylococcus aureus . Sebelum dilakukan uji antibakteri, sampel yang telah diekstrak secara maserasi diuji fitokimia terlebih dahulu untuk menentukan kandungan metabolit sekunder yang telah diketahui berperan sebagai agen antibakteri. Setelah dilakukan uji fitokimia, ekstrak diuji aktivitas antibakterinya terhadap bakteri Staphylococcus aureus dengan menggunakan teknik difusi agar dengan cara sumuran. Ekstrak dilarutkan pada aquades steril dengan perbandingan 2 g ekstrak pada 2 mL air. Untuk kontrol positif, digunakan ciprofloxacin dan aquades steril sebagai kontrol negatif. Hasil penelitian ini menunjukkan bahwa ekstrak kulit batang matoa memiliki aktivitas antibakteri setelah diinkubasi selama 24 jam pada 37 OC. Dari 3 kali pengulangan dengan masing – masing 3 sumuran, didapat zona hambat masing – masing 16.84 mm, 12.5 mm dan 14.5 mm dengan kontrol positif 29.67 mm serta kontrol negatif 0 mm. Hasil yang diperoleh didukung oleh keberadaan metabolit sekunder hasil uji fitokimia yaitu tanin, flavonoid, terpenoid dan saponin.A qualitative study has done of the antibacterial effect of matoa (Pometia pinnata) stem bark extract against Gram-positive bacteria Staphylococcus aureus . Before the antibacterial test , samples were extracted by maceration and then phytochemical tested to measuring the content of secondary metabolites that have been known to act as an antibacterial agent . After being tested of phytochemical , extracts were tested the antibacterial effect against Staphylococcus aureus using agar diffusion technique. Extract was dissolved in sterile distilled water with a ratio of 2 g of extract in 2 mL of water . For the positive control , use of ciprofloxacin and sterile distilled water as a negative control . Results of this study indicate that matoa bark extract has antibacterial effect after incubation for 24 h at 37OC . Of 3 times with each repetition - each 3 wells, the inhibition zone obtained - each 16.84 mm , 12.5 mm and 14.5 mm with 29.67 mm of positive control and a negative control by 0 mm . The results are supported by the presence of secondary metabolites by phytochemical test such as tannins , flavonoids , terpenoids and saponins.

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