Aaptamine derivatives with CDK2 inhibitory activities from the South China Sea sponge Aaptos suberitoides

2022 ◽  
pp. 1-9
Author(s):  
Qian-Qian He ◽  
Yu-Qing Man ◽  
Kun-Lai Sun ◽  
Li-Juan Yang ◽  
Yan Wu ◽  
...  
Keyword(s):  
South China Sea ◽  
South China ◽  
The South China Sea ◽  
The South ◽  
China Sea ◽  
Inhibitory Activities

scholarly journals New sesquiterpenoids from the South China Sea soft corals Clavularia viridis and Lemnalia flava

2019 ◽  
Vol 15 ◽  
pp. 695-702
Author(s):  
Qihao Wu ◽  
Yuan Gao ◽  
Meng-Meng Zhang ◽  
Li Sheng ◽  
Jia Li ◽  
...  
Keyword(s):  
South China Sea ◽  
South China ◽  
Spectroscopic Analysis ◽  
The South China Sea ◽  
Soft Corals ◽  
The South ◽  
China Sea ◽  
Inhibitory Activities ◽  
Detailed Chemical

A detailed chemical investigation of the South China Sea soft corals Clavularia viridis and Lemnalia flava yielded four new halogenated laurane-type sesquiterpenoids, namely, isobromolaurenisol (1), clalaurenol A (2), ent-laurenisol (3), clalaurenol B (4), and the new aromadendrane-type sesquiterpenoid claaromadendrene (6), together with three known sesquiterpenoids (5, 7, and 8). Their structures were determined by extensive spectroscopic analysis and by comparison with the previously reported analogues. In a bioassay, compounds 1, 2 and 4 exhibited interesting inhibitory activities in vitro against PTP1B and NF-κB.

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