Recent progress in protein-protein interaction study for EGFR-targeted therapeutics

2016 ◽  
Vol 13 (9) ◽  
pp. 817-832 ◽  
Author(s):  
Rebecca Christine Feiner ◽  
Kristian Mark Müller
Keyword(s):  
Protein Interaction ◽  
Recent Progress ◽  
Targeted Therapeutics ◽  
Interaction Study ◽  
Protein Protein Interaction

The Development of Inhibitors Targeting the Mixed Lineage Leukemia 1 (MLL1)-WD Repeat Domain 5 Protein (WDR5) Protein- Protein Interaction

2020 ◽  
Vol 27 (33) ◽  
pp. 5530-5542
Author(s):  
Xiaoqing Ye ◽  
Gang Chen ◽  
Jia Jin ◽  
Binzhong Zhang ◽  
Yinda Wang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Protein Interaction ◽  
Fusion Proteins ◽  
Recent Progress ◽  
Mixed Lineage Leukemia ◽  
Core Complex ◽  
Histone Methyltransferases ◽  
Protein Protein Interaction ◽  
Histone 3 ◽  
Repeat Domain

Mixed Lineage Leukemia 1 (MLL1), an important member of Histone Methyltransferases (HMT) family, is capable of catalyzing mono-, di-, and trimethylation of Histone 3 lysine 4 (H3K4). The optimal catalytic activity of MLL1 requires the formation of a core complex consisting of MLL1, WDR5, RbBP5, and ASH2L. The Protein-Protein Interaction (PPI) between WDR5 and MLL1 plays an important role in abnormal gene expression during tumorigenesis, and disturbing this interaction may have a potential for the treatment of leukemia harboring MLL1 fusion proteins. In this review, we will summarize recent progress in the development of inhibitors targeting MLL1- WDR5 interaction.

Dynamic sandwich-type electrochemical assay for protein quantification and protein–protein interaction

The Analyst ◽  
2017 ◽  
Vol 142 (23) ◽  
pp. 4399-4404 ◽  
Author(s):  
Chao Li ◽  
Yaqin Tao ◽  
Yi Yang ◽  
Chang Feng ◽  
Yang Xiang ◽  
...  
Keyword(s):  
Protein Interaction ◽  
Electrochemical Method ◽  
Protein Quantification ◽  
Interaction Study ◽  
Electrochemical Assay ◽  
Protein Protein Interaction ◽  
Sandwich Type

A versatile and sensitive electrochemical method for protein–protein interaction study based on DNAzyme has been proposed.

Recent advances in the techniques of protein-protein interaction study

2013 ◽  
Vol 35 (11) ◽  
pp. 1274-1282
Author(s):  
Ming-Qiang WANG ◽  
Jin-Xia WU ◽  
Yu-Hong ZHANG ◽  
Ning HAN ◽  
Hong-Wu BIAN ◽  
...  
Keyword(s):  
Protein Interaction ◽  
Interaction Study ◽  
Protein Protein Interaction ◽  
Recent Advances

Recent progress in Keap1-Nrf2 protein-protein interaction inhibitors

2020 ◽  
Vol 202 ◽  
pp. 112532 ◽  
Author(s):  
Yi Mou ◽  
Shuai Wen ◽  
Yu-Xiu Li ◽  
Xin-Xing Gao ◽  
Xin Zhang ◽  
...  
Keyword(s):  
Protein Interaction ◽  
Recent Progress ◽  
Protein Protein Interaction ◽  
Nrf2 Protein
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