Bacterial Multidrug Resistance Mediated by a Homologue of the Human Multidrug Transporter P-glycoprotein

IUBMB Life ◽  
2002 ◽  
Vol 53 (4-5) ◽  
pp. 213-218 ◽  
Author(s):  
Wil N. Konings ◽  
Gerrit J. Poelarends
Keyword(s):  
Multidrug Resistance ◽  
Multidrug Transporter ◽  
P Glycoprotein

scholarly journals Directed evolution of P-glycoprotein cysteines reveals site-specific, non-conservative substitutions that preserve multidrug resistance

2014 ◽  
Vol 34 (3) ◽  
Author(s):  
Douglas J. Swartz ◽  
Leo Mok ◽  
Sri K. Botta ◽  
Anukriti Singh ◽  
Guillermo A. Altenberg ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Directed Evolution ◽  
Multidrug Transporter ◽  
Site Specific ◽  
P Glycoprotein ◽  
Domain Interactions

Directed evolution of Cys (cysteines) in the multidrug transporter Pgp identified novel non-conservative substitutions, revealed important domain interactions and produced a CL protein that is more robust and active than previous CL Pgp built solely on conservative alanine substitutions.

scholarly journals Analysis of Multidrug Transporter in Living Cells. Inhibition of P-glycoprotein-mediated Efflux of Anthracyclines by Ionophores

1994 ◽  
Vol 1 (2-3) ◽  
pp. 175-182 ◽  
Author(s):  
Marie-Nicole Borrel ◽  
Elene Pereira ◽  
Marina Fiallo ◽  
Arlette Garnier-Suillerot
Keyword(s):  
Multidrug Resistance ◽  
Membrane Protein ◽  
Tumor Cells ◽  
Chelating Agent ◽  
Living Cells ◽  
Drug Accumulation ◽  
Multidrug Transporter ◽  
Drug Efflux ◽  
Cellular Resistance ◽  
P Glycoprotein

One of the major obstacles of chemotherapy is that, after repeated treatments, cellular resistance to the drug appears. The problem is that the tumor cells become resistant not only to the drugs which have been used during the treatment but also to other drugs which are structurally and functionally unrelated. This is termed ‘multidrug resistance’ (MDR). MDR is frequently associated with decreased drug accumulation resulting from enhanced drug efflux. This is correlated with the presence of a membrane protein, P-glycoprotein, which pumps a wide variety of drugs out of cells thus reducing their toxicity. The search for molecules able to reverse MDR is very important. We here report that mobile ionophores such as valinomycin, nonactin, nigericin, monensin, calcimycin, lasalocid inhibit the efflux of anthracycline by P-glycoprotein whereas, channel-forming ionophores such as gramicidin do not. Cyclosporin which is also a strong Ca2+ chelating agent also inhibits the P-glycoprotein-mediated efflux of anthracycline.

Transfection with Protein Kinase Cα Confers Increased Multidrug Resistance to MCF-7 Cells Expressing P-Glycoprotein

1991 ◽  
Vol 3 (6) ◽  
pp. 181-189 ◽  
Author(s):  
Gang Yu ◽  
Shakeel Ahmad ◽  
Angelo Aquino ◽  
Craig R. Fairchild ◽  
Jane B. Trepel ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Protein Kinase ◽  
P Glycoprotein ◽  
Protein Kinase Cα ◽  
Mcf 7

scholarly journals Modulation of the expression of a multidrug resistance gene (mdr-1/P-glycoprotein) by differentiating agents

1989 ◽  
Vol 264 (30) ◽  
pp. 18031-18040
Author(s):  
L A Mickley ◽  
S E Bates ◽  
N D Richert ◽  
S Currier ◽  
S Tanaka ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Resistance Gene ◽  
Multidrug Resistance Gene ◽  
P Glycoprotein ◽  
Differentiating Agents ◽  
Mdr 1

Designing potent inhibitors against the multidrug resistance P-glycoprotein

2021 ◽  
pp. 1-13
Author(s):  
Shafi Mahmud ◽  
Md. Jahirul Islam ◽  
Md. Rimon Parves ◽  
Md. Arif Khan ◽  
Lamiya Tabussum ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
P Glycoprotein

scholarly journals Retraction Note: Flavonoids modulate multidrug resistance through wnt signaling in P-glycoprotein overexpressing cell lines

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
S. Mohana ◽  
M. Ganesan ◽  
N. Rajendra Prasad ◽  
D. Ananthakrishnan ◽  
D. Velmurugan
Keyword(s):  
Multidrug Resistance ◽  
Wnt Signaling ◽  
Cell Lines ◽  
P Glycoprotein ◽  
Overexpressing Cell

An amendment to this paper has been published and can be accessed via the original article.

scholarly journals Reversal of multidrug resistance by calcium channel blocker SR33557 without photoaffinity labeling of P-glycoprotein.

1991 ◽  
Vol 266 (29) ◽  
pp. 19858-19864
Author(s):  
J.P. Jaffrézou ◽  
J.M. Herbert ◽  
T. Levade ◽  
M.N. Gau ◽  
P. Chatelain ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Channel Blocker ◽  
Photoaffinity Labeling ◽  
P Glycoprotein
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