scholarly journals Upregulation of microRNA-129-5p inhibits cell invasion, migration and tumor angiogenesis by inhibiting ZIC2 via downregulation of the Hedgehog signaling pathway in cervical cancer

2018 ◽  
Vol 19 (12) ◽  
pp. 1162-1173 ◽  
Author(s):  
Ying-Fang Wang ◽  
Hong-Yun Yang ◽  
Xiao-Qin Shi ◽  
Yue Wang
Keyword(s):  
Cervical Cancer ◽  
Signaling Pathway ◽  
Cell Invasion ◽  
Tumor Angiogenesis ◽  
Hedgehog Signaling ◽  
Hedgehog Signaling Pathway

SOX2 regulates radioresistance in cervical cancer via the hedgehog signaling pathway

2018 ◽  
Vol 151 (3) ◽  
pp. 533-541 ◽  
Author(s):  
Chunxian Huang ◽  
Huaiwu Lu ◽  
Jing Li ◽  
Xiaofei Xie ◽  
Li Fan ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Signaling Pathway ◽  
Hedgehog Signaling ◽  
Hedgehog Signaling Pathway

scholarly journals Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation

2008 ◽  
Vol 30 (1) ◽  
pp. 131-140 ◽  
Author(s):  
Xiaoyun Liao ◽  
Michelle K.Y. Siu ◽  
Christy W.H. Au ◽  
Esther S.Y. Wong ◽  
Hoi Yan Chan ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Cell Invasion ◽  
Hedgehog Signaling ◽  
Hedgehog Signaling Pathway ◽  
Ovarian Cancers

scholarly journals The Roles of Hedgehog Signaling Pathway in Radioresistance of Cervical Cancer

Dose-Response ◽  
2019 ◽  
Vol 17 (4) ◽  
pp. 155932581988529 ◽  
Author(s):  
Chang Liu ◽  
Rensheng Wang
Keyword(s):  
Cervical Cancer ◽  
Drug Resistance ◽  
Targeted Therapy ◽  
Signaling Pathway ◽  
Hedgehog Signaling ◽  
Essential Role ◽  
Hedgehog Signaling Pathway ◽  
Advanced Cervical Cancer ◽  
New Strategy ◽  
The Relationship

Radiotherapy is an important treatment of cervical cancer, especially for advanced cervical cancer. According to research reports, Hedgehog signaling pathway plays an essential role in the growth, invasion, metastasis, recurrence, drug resistance, and radioresistance of cervical cancer. The components of Hedgehog signaling pathway could be biomarkers, related to progression and prognosis of cervical cancer. In addition, targeted therapy for Hedgehog signaling pathway is expected to become a new strategy for the treatment of radioresistant cervical cancer. This review summarizes the research status and progress of the relationship between radiation resistance and activation of Hedgehog signaling pathway in cervical cancer.

Relationship between lipid metabolism and Hedgehog signaling pathway

2021 ◽  
Vol 209 ◽  
pp. 105825
Author(s):  
Yuan Gu ◽  
Xiaochen Liu ◽  
Lele Liao ◽  
Yongquan Gao ◽  
Yu Shi ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Signaling Pathway ◽  
Hedgehog Signaling ◽  
Hedgehog Signaling Pathway

scholarly journals The Role of Sonic Hedgehog-Gli2 Pathway in the Masculinization of External Genitalia

Endocrinology ◽  
2011 ◽  
Vol 152 (7) ◽  
pp. 2894-2903 ◽  
Author(s):  
Shinichi Miyagawa ◽  
Daisuke Matsumaru ◽  
Aki Murashima ◽  
Akiko Omori ◽  
Yoshihiko Satoh ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Sonic Hedgehog ◽  
Hedgehog Signaling ◽  
External Genitalia ◽  
Sexually Dimorphic ◽  
Hedgehog Signaling Pathway ◽  
Initial Development ◽  
Urethral Plate ◽  
Male External Genitalia

During embryogenesis, sexually dimorphic organogenesis is achieved by hormones produced in the gonad. The external genitalia develop from a single primordium, the genital tubercle, and their masculinization processes depend on the androgen signaling. In addition to such hormonal signaling, the involvement of nongonadal and locally produced masculinization factors has been unclear. To elucidate the mechanisms of the sexually dimorphic development of the external genitalia, series of conditional mutant mouse analyses were performed using several mutant alleles, particularly focusing on the role of hedgehog signaling pathway in this manuscript. We demonstrate that hedgehog pathway is indispensable for the establishment of male external genitalia characteristics. Sonic hedgehog is expressed in the urethral plate epithelium, and its signal is mediated through glioblastoma 2 (Gli2) in the mesenchyme. The expression level of the sexually dimorphic genes is decreased in the glioblastoma 2 mutant embryos, suggesting that hedgehog signal is likely to facilitate the masculinization processes by affecting the androgen responsiveness. In addition, a conditional mutation of Sonic hedgehog at the sexual differentiation stage leads to abnormal male external genitalia development. The current study identified hedgehog signaling pathway as a key factor not only for initial development but also for sexually dimorphic development of the external genitalia in coordination with androgen signaling.

Sign in / Sign up

Export Citation Format

Share Document