scholarly journals STAT3-induced upregulation of long noncoding RNA HNF1A-AS1 promotes the progression of oral squamous cell carcinoma via activating Notch signaling pathway

2018 ◽  
Vol 20 (4) ◽  
pp. 444-453 ◽  
Author(s):  
Zhe Liu ◽  
Hong Li ◽  
Sumeng Fan ◽  
Hui Lin ◽  
Wenwei Lian
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Notch Signaling ◽  
Cell Carcinoma ◽  
Signaling Pathway ◽  
Squamous Cell ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Notch Signaling Pathway

scholarly journals Correction to: LncRNA NEAT1 mediates progression of oral squamous cell carcinoma via VEGF-A and Notch signaling pathway

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Ke He ◽  
Zhi-Bin Zhu ◽  
Rui Shu ◽  
Ai Hong
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Notch Signaling ◽  
Cell Carcinoma ◽  
Signaling Pathway ◽  
Squamous Cell ◽  
Notch Signaling Pathway ◽  
Lncrna Neat1

An amendment to this paper has been published and can be accessed via the original article.

scholarly journals LncRNA NEAT1 mediates progression of oral squamous cell carcinoma via VEGF-A and Notch signaling pathway

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Ke He ◽  
Zhi-Bin Zhu ◽  
Rui Shu ◽  
Ai Hong
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Notch Signaling ◽  
Cell Carcinoma ◽  
Cell Line ◽  
Signaling Pathway ◽  
Cell Lines ◽  
Squamous Cell ◽  
Notch Signaling Pathway ◽  
Lncrna Neat1

Abstract Background lncRNAs and VEGF have been shown to have close connections with oral squamous cell carcinoma (OSCC). We explored the interaction between lncRNA NEAT1 and VEGF-A in OSCC. Methods RT-qPCR was implemented to measure levels of lncRNA NEAT1 and VEGF-A in OSCC cell lines and normal cell lines. Cell functions then were checked after regulating the expressions of lncRNA NEAT1 and VEGF-A separately. Cell viabilities were examined with CCK-8 and apoptosis rate was checked with flow cytometry. Meanwhile, EMT-related genes E-cadherin, N-cadherin, Vimentin, and Snail and Notch signaling genes Notch1, Notch2, and Jagged were evaluated by RT-qPCR. IMR-1 was applied for impeding Notch signaling pathway. Later, cell viabilities, apoptosis, and EMT were assessed. Results Expressions of lncRNA NEAT1 and VEGF-A were both increased significantly in OSCC cell lines especially in TSCC1 cell line. Suppression of lncNRA NEAT1 was associated with lower cell viabilities and EMT and higher apoptosis rate in the TSCC1 cell line. Meanwhile, knockdown of VEGF-A significantly repressed cell viabilities and EMT in the TSCC1 cell line. Magnifying functions of inhibited lncRNA NEAT1 Notch signaling pathway was obviously activated with overexpressions of lncRNA NEAT1 and VEGF-A. Adding IMR-1 significantly downregulated cell viabilities and EMT and sharply increased apoptosis in the context of lncRNA NEAT1 and VEGF-A overexpression. Conclusion LncRNA NEAT1 may upregulate proliferation and EMT and repress apoptosis through activating VEGF-A and Notch signaling pathway in vitro, suggesting an underlying regulatory factor in OSCC. Nevertheless, further research is necessary to gain a greater understanding of lncRNA NEAT1 and connections with VEGF-A in vivo and in clinical study.

TWIST1 correlates with Notch signaling pathway to develop esophageal squamous cell carcinoma

2020 ◽  
Vol 474 (1-2) ◽  
pp. 181-188 ◽  
Author(s):  
Yasaman Fahim ◽  
Mozhgan Yousefi ◽  
Mohammad Hossein Izadpanah ◽  
Mohammad Mahdi Forghanifard
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Notch Signaling ◽  
Cell Carcinoma ◽  
Signaling Pathway ◽  
Squamous Cell ◽  
Notch Signaling Pathway

Long noncoding RNA HAS2-AS1 mediates hypoxia-induced invasiveness of oral squamous cell carcinoma

2017 ◽  
Vol 56 (10) ◽  
pp. 2210-2222 ◽  
Author(s):  
Guiquan Zhu ◽  
Shaoxin Wang ◽  
Jin Chen ◽  
Zhaohui Wang ◽  
Xinhua Liang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Long Noncoding Rna ◽  
Noncoding Rna
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