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<p>Here we show the
development of heterobifunctional small molecules capable of selectively targeting MCL1 using
a Proteolysis Targeting Chimera (PROTAC) methodology leading to successful degradation. We
have confirmed the involvement of the E3 ligase CUL4A-DDB1 cereblon (CRBN) ubiquitination
pathway, making these PROTACs a first step toward a new class of anti-apoptotic BCL-2 family
protein degraders.
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A new flavor of cellular Atg8-family protein lipidation – alternative conjugation to phosphatidylserine during CASM
