Development of functionally-graded reservoir of PCL/PG by selective laser sintering for drug delivery devices

Selective laser sintering (SLS) is a rapid prototype process that creates objects, layer by layer, using infrared laser beams to process powder materials [1–8]. In recent years, the SLS process has shown great prominence in the medical field, and several researchers have conducted studies showing a wide diversity of materials and applications, such as the manufacture of porous drug delivery devices (DDDs) [9–12].

Download Full-text

Fabrication of porous polymeric matrix drug delivery devices using the selective laser sintering technique

Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine ◽

10.1243/0954411011533751 ◽

2001 ◽

Vol 215 (2) ◽

pp. 191-192 ◽

Cited By ~ 62

Author(s):

K F Leong ◽

K K S Phua ◽

C K Chua ◽

Z H Du ◽

K O M Teo

Keyword(s):

Drug Delivery ◽

Laser Power ◽

Selective Laser Sintering ◽

Laser Sintering ◽

Polymeric Matrix ◽

Beam Power ◽

Blue Dye ◽

Scan Speed ◽

Drug Delivery Devices ◽

Fractional Release

New techniques in solid freeform fabrication (SFF) have prompted research into methods of manufacturing and controlling porosity. The strategy of this research is to integrate computer aided design (CAD) and the SFF technique of selective laser sintering (SLS) to fabricate porous polymeric matrix drug delivery devices (DDDs). This study focuses on the control of the porosity of a matrix by manipulating the SLS process parameters of laser beam power and scan speed. Methylene blue dye is used as a drug model to infiltrate the matrices via a degassing method; visual inspection of dye penetration into the matrices is carried out. Most notably, the laser power matrices show a two-stage penetration process. The matrices are sectioned along the XZ planes and viewed under scanning electron microscope (SEM). The morphologies of the samples reveal a general increase in channel widths as laser power decreases and scan speed increases. The fractional release profiles of the matrices are determined by allowing the dye to diffuse out in vitro within a controlled environment. The results show that laser power and scan speed matrices deliver the dye for 8-9 days and have an evenly distributed profile. Mercury porosimetry is used to analyse the porosity of the matrices. Laser power matrices show a linear relationship between porosity and variation in parameter values. However, the same relationship for scan speed matrices turns out to be rather inconsistent. Relationships between the SLS parameters and the experimental results are developed using the fractional release rate equation for the infinite slab porous matrix DDD as a basis for correlation.

Download Full-text

Microstructural characterization and mechanical properties of functionally graded PA12/HDPE parts by selective laser sintering

The International Journal of Advanced Manufacturing Technology ◽

10.1007/s00170-011-3538-5 ◽

2011 ◽

Vol 59 (5-8) ◽

pp. 583-591 ◽

Cited By ~ 23

Author(s):

Janaina Lisi Leite ◽

Gean Victor Salmoria ◽

Rodrigo A. Paggi ◽

Carlos Henrique Ahrens ◽

Antonio Sérgio Pouzada

Keyword(s):

Mechanical Properties ◽

Selective Laser Sintering ◽

Microstructural Characterization ◽

Laser Sintering ◽

Functionally Graded

Download Full-text

Development of functionally graded biomaterial scaffolds using selective laser sintering

10.32657/10356/40749 ◽

2010 ◽

Author(s):

Novella Sudarmadji

Keyword(s):

Selective Laser Sintering ◽

Laser Sintering ◽

Functionally Graded ◽

Biomaterial Scaffolds

Download Full-text

Characterization of microfeatures in selective laser sintered drug delivery devices

Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine ◽

10.1243/095441102321032166 ◽

2002 ◽

Vol 216 (6) ◽

pp. 369-383 ◽

Cited By ~ 54

Author(s):

C M Cheah ◽

K F Leong ◽

C K Chua ◽

K H Low ◽

H S Quek

Keyword(s):

Drug Delivery ◽

Selective Laser Sintering ◽

In Vitro Release ◽

Porous Matrix ◽

Structural Examination ◽

Wall Formation ◽

Polymeric Drug Delivery ◽

Porous Microstructure ◽

Drug Delivery Devices

From initial applications in the fields of prosthesis, implants, surgery planning, anthropology, paleontology and forensics, the scope of rapid prototyping (RP) biomedical applications has expanded to include areas in tissue engineering (TE) and controlled drug delivery. In the current investigation, the feasibility of utilizing selective laser sintering (SLS) to fabricate polymeric drug delivery devices (DDDs) that are difficult to make using conventional production methods was studied. Two features, namely porous microstructure and dense wall formation, inherent in SLS fabricated parts were investigated for their potential roles in drug storage and controlling the release of drugs through the diffusion process. A study to determine the influence of key SLS process parameters on dense wall formation and porous microstructure of SLS fabricated parts was carried out. Composite-type DDDs incorporating dense wall and porous matrix features were designed and fabricated using SLS. The characteristics of the fabricated devices were investigated through micro-structural examination and in vitro release tests carried out using a drug model or dye in a simulated body environment.

Download Full-text