Hippocampal volume, function, and related molecular activity in anorexia nervosa: A scoping review

Author(s):  
Johanna Keeler ◽  
Olivia Patsalos ◽  
Sandrine Thuret ◽  
Stefan Ehrlich ◽  
Kate Tchanturia ◽  
...  
2020 ◽  
Author(s):  
Johanna Louise Keeler ◽  
Olivia Patsalos ◽  
Sandrine Thuret ◽  
Hubertus Himmerich ◽  
Janet Treasure

Anorexia Nervosa (AN) is a serious mental health condition, which commonly follows a chronic course, termed severe-enduring AN (SE-AN). Recent evidence suggests SE-AN may be underpinned by an interaction between genetic risk factors, the endocrinological, immune and metabolic systems and deficiencies in neural structures. One structure found to be implicated over the course of AN is the hippocampus, which similarly has shown to be affected in other psychiatric disorders. The hippocampus is involved in processes such as memory and learning, as well as in the regulation of food intake. The literature on the hippocampus and AN is relatively heterogeneous and no reviews of hippocampal integrity in AN have been conducted. We will conduct a systematic scoping review of hippocampal volume, function and connectivity, as well as molecular components associated with hippocampal neurogenesis, to assess the variability in the literature and the current consensus on the hippocampus in AN.We will use methods based on the Joanna Briggs Institute scoping review methods manual. Studies of any design in populations of AN with outcomes pertaining to our inclusion criteria will be located using an electronic database search of MEDLINE (PubMed), Web Of Science and PsychINFO. Two reviewers will independently screen titles, abstracts and full-texts and chart data of eligible studies. Study characteristics will be summarised during data analysis. Reported outcomes will include main study findings and methodology.


Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2834
Author(s):  
Lisa Brelet ◽  
Valentin Flaudias ◽  
Michel Désert ◽  
Sébastien Guillaume ◽  
Pierre-Michel Llorca ◽  
...  

Research about stigmatization in eating disorders (EDs) has highlighted stereotypes, prejudices, and discrimination against people with EDs, as well as their harmful effects on them, including self-stigma and a difficult recovery process. Whereas a recent review focused on the consequences of ED stigma, our work aimed to provide a broader synthesis of ED stigma, including its consequences, but also its content and distribution. More precisely, we focused on three EDs—namely, anorexia nervosa, bulimia nervosa, and binge eating disorder. Based on a systematic search of four major databases in psychology, the present scoping review includes 46 studies published between 2004 and 2021. We did not conduct any quality assessment of the studies included, because our aim was to provide a wide-ranging overview of these topics instead of an appraisal of evidence answering a precise research question. The review confirmed the existence of a common ED stigma: all individuals affected by EDs reviewed here were perceived as responsible for their situation, and elicited negative emotions and social distance. However, our review also depicted a specific stigma content associated with each ED. In addition, the demographic characteristics of the stigmatizing individuals had a notable influence on the extent of ED stigma: men, young adults, and low-income individuals appeared to be the most stigmatizing toward individuals with EDs. It is important to note that ED stigma had a negative effect on individuals’ eating disorders, psychological wellbeing, and treatment-seeking behavior. There is an urgent need for further research on the adverse effects of ED stigma and its prevention.


2006 ◽  
Vol 146 (2) ◽  
pp. 117-125 ◽  
Author(s):  
Frances Connan ◽  
Fay Murphy ◽  
Steve E.J. Connor ◽  
Phil Rich ◽  
Tara Murphy ◽  
...  

2020 ◽  
Vol 53 (9) ◽  
pp. 1377-1399
Author(s):  
Tom Price ◽  
Martin Zebitz ◽  
Annamaria Giraldi ◽  
Thea Stine Lokind ◽  
Janet Treasure ◽  
...  

2020 ◽  
Vol 28 (6) ◽  
pp. 605-619
Author(s):  
Mia Eskild‐Jensen ◽  
René K. Støving ◽  
Christopher F. Flindt ◽  
Magnus Sjogren

2021 ◽  
Vol 12 (1) ◽  
pp. 204380872098734
Author(s):  
Max Teaford ◽  
Matthew S. McMurray ◽  
Vincent Billock ◽  
Madison Filipkowski ◽  
L. James Smart

Anorexia nervosa (AN) is a severe psychiatric disorder characterized by a number of symptoms including food restriction and body perception distortions. In the present scoping review, we outline the current literature on sensory submodalities related to the somatosensory system in AN including affective touch, haptic perception, interoception, nociception, proprioception, and tactile perception as well as multisensory integration. The evidence suggests that individuals with AN exhibit abnormalities in multisensory integration, discrimination (but not detection) of complex haptic and tactile stimuli, and reduced sensitivity to nociceptive stimuli. This review provides an outline of the current literature, identifies gaps within the literature, and suggests novel directions for future research.


2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Tone Seim Fuglset ◽  
Nils Inge Landrø ◽  
Deborah Lynn Reas ◽  
Øyvind Rø

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