scholarly journals Hippocampal volume, function and connectivity in anorexia nervosa: a systematic scoping review protocol

2020 ◽  
Author(s):  
Johanna Louise Keeler ◽  
Olivia Patsalos ◽  
Sandrine Thuret ◽  
Hubertus Himmerich ◽  
Janet Treasure

Anorexia Nervosa (AN) is a serious mental health condition, which commonly follows a chronic course, termed severe-enduring AN (SE-AN). Recent evidence suggests SE-AN may be underpinned by an interaction between genetic risk factors, the endocrinological, immune and metabolic systems and deficiencies in neural structures. One structure found to be implicated over the course of AN is the hippocampus, which similarly has shown to be affected in other psychiatric disorders. The hippocampus is involved in processes such as memory and learning, as well as in the regulation of food intake. The literature on the hippocampus and AN is relatively heterogeneous and no reviews of hippocampal integrity in AN have been conducted. We will conduct a systematic scoping review of hippocampal volume, function and connectivity, as well as molecular components associated with hippocampal neurogenesis, to assess the variability in the literature and the current consensus on the hippocampus in AN.We will use methods based on the Joanna Briggs Institute scoping review methods manual. Studies of any design in populations of AN with outcomes pertaining to our inclusion criteria will be located using an electronic database search of MEDLINE (PubMed), Web Of Science and PsychINFO. Two reviewers will independently screen titles, abstracts and full-texts and chart data of eligible studies. Study characteristics will be summarised during data analysis. Reported outcomes will include main study findings and methodology.

Author(s):  
Johanna Keeler ◽  
Olivia Patsalos ◽  
Sandrine Thuret ◽  
Stefan Ehrlich ◽  
Kate Tchanturia ◽  
...  

2020 ◽  
Vol 3 (1) ◽  
pp. 9
Author(s):  
Matthias Lukasczik ◽  
Christian Gerlich ◽  
Hans Dieter Wolf ◽  
Heiner Vogel

Question prompt lists (QPL) are an instrument to promote patient participation in medical encounters by providing a set of questions patients can use during consultations. QPL have predominantly been examined in oncology. Less is known about their use in other contexts. Therefore, we plan to conduct a scoping review to provide an overview of the fields of healthcare in which QPL have been developed and evaluated. MEDLINE/PUBMED, PSYCINFO, PSYNDEX, WEB OF SCIENCE, and CINAHL will be systematically searched. Primary studies from different healthcare contexts that address the following participants/target groups will be included: persons with an acute, chronic, or recurring health condition other than cancer; healthy persons in non-oncological primary preventive measures. There will be no restrictions in terms of study design, sample size, or outcomes. However, only published studies will be included. Studies that were published in English and German between 1990 and 2019 will be examined. Two independent reviewers will apply defined inclusion/exclusion criteria and determine study eligibility in the review process guided by the PRISMA statement.


Author(s):  
Anne Rix ◽  
Renée Girbig ◽  
Céline Porte ◽  
Wiltrud Lederle ◽  
Cathalijn Leenaars ◽  
...  

Abstract Purpose Publication numbers reporting that ultrasound can stimulate immune reactions in tumors steadily increase. However, the presented data are partially conflicting, and mechanisms are difficult to identify from single publications. These shortcomings can be addressed by a systematic review and meta-analysis of current literature. As a first step, we here present the methodology and protocol for a systematic review to answer the following research question: Does ultrasound alter the immune reaction of peripheral solid tumors in humans and animals compared to control conditions without ultrasound? Procedures We designed a protocol to perform a systematic review and meta-analysis. The suitability of the protocol to detect and sort relevant literature was tested using a subset of publications. We extracted study characteristics, ultrasound parameters, and study outcomes to pre-evaluate the differences between publications and present the data as a scoping review. Results From 6532 publications detected by our preliminary literature search, 320 were selected for testing our systematic review protocol. Of the latter, 15 publications were eligible for data extraction. There, we found large differences between study characteristics (e.g., tumor type, age) and ultrasound settings (e.g., wavelength 0.5–9.5 MHz, acoustic pressure 0.0001–15,000 W/cm2). Finally, study outcomes included reports on cells of the innate (e.g., dendritic cells, macrophages) and adaptive immune system (e.g., CD8-/CD4-positive T cells). Conclusion We designed a protocol to identify relevant literature and perform a systematic review and meta-analysis. The differences between extracted features between publications show the necessity for a comprehensive search and selection strategy in the systematic review to get a complete overview of the literature. Meta-analyses of the extracted outcomes can then enable evidence-based conclusions.


2021 ◽  
Author(s):  
Johanna Louise Keeler ◽  
Rosemarie Keeler-Schaffeler ◽  
Hubertus Himmerich ◽  
Janet Treasure

Introduction Anorexia Nervosa (AN) is a serious mental health condition, which commonly follows a chronic course. Recent evidence suggests SE-AN may be underpinned by an interaction between genetic risk factors, the endocrinological, immune and metabolic systems and deficiencies in neural structures. Previous meta-analyses have identified increases in certain pro-inflammatory cytokines in AN, which may contribute to neuroinflammation. However, there has not yet been an investigation of growth factor concentrations in individuals with AN. We aim to conduct a systematic review and meta-analysis of growth factor concentrations in individuals with AN compared to healthy individuals, and of individuals longitudinally (i.e. after an improvement in weight and/or symptoms). Methods and analysis We will use a systematic review and meta-analysis based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (Moher et al., 2009). Studies of any design in populations of AN with outcomes pertaining to serum, plasma or cerebrospinal growth factor concentrations will be located using an electronic database search of PudMed, ISI Web of Science Core Collection and MEDLINE. Two reviewers will independently screen titles, abstracts and full-texts and chart data of eligible studies. Study characteristics will be summarised during data analysis. Reported outcomes will include standardised mean differences between groups (AN vs. healthy controls, AN longitudinally) of individual growth factors.


BMJ Open ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. e043374
Author(s):  
Khara Sauro ◽  
Arjun Maini ◽  
Matthew Machan ◽  
Diane Lorenzetti ◽  
Shamir Chandarana ◽  
...  

IntroductionTransitions in Care (TiC) are vulnerable periods in care delivery associated with adverse events, increased cost and decreased patient satisfaction. Patients with cancer encounter many transitions during their care journey due to improved survival rates and the complexity of treatment. Collectively, improving TiC is particularly important among patients with cancer. The objective of this scoping review is to synthesise and map the existing literature regarding TiC among patients with cancer in order to explore opportunities to improve TiC among patients with cancer.Methods and analysisThis scoping review will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analysis-Scoping Review Extension and the Joanna Briggs Institute methodology. The PubMed cancer filter and underlying search strategy will be tailored to each database (Embase, Cochrane, CINAHL and PsycINFO) and combined with search terms for TiC. Grey literature and references of included studies will be searched. The search will include studies published from database inception until 9 February 2020. Quantitative and qualitative studies will be included if they describe transitions between any type of healthcare provider or institution among patients with cancer. Descriptive statistics will summarise study characteristics and quantitative data of included studies. Qualitative data will be synthesised using thematic analysis.Ethics and disseminationOur objective is to synthesise and map the existing evidence; therefore, ethical approval is not required. Evidence gaps around TiC will inform a programme of research aimed to improve high-risk transitions among patients with cancer. The findings of this scoping review will be published in a peer-reviewed journal and widely presented at academic conferences. More importantly, decision makers and patients will be provided a summary of the findings, along with data from a companion study, to prioritise TiC in need of interventions to improve continuity of care for patients with cancer.


2020 ◽  
Author(s):  
Amanda S Newton ◽  
Sonja March ◽  
Nicole D Gehring ◽  
Arlen K Rowe ◽  
Ashley D Radomski

BACKGROUND Across eHealth intervention studies involving children, adolescents, and their parents, researchers have measured users’ experiences to assist with intervention development, refinement, and evaluation. To date, there are no widely agreed-on definitions or measures of ‘user experience’ to support a standardized approach for evaluation and comparison within or across interventions. OBJECTIVE We conducted a scoping review with subsequent Delphi consultation to (1) identify how user experience is defined and measured in eHealth research studies, (2) characterize the measurement tools used, and (3) establish working definitions for domains of user experience that could be used in future eHealth evaluations. METHODS We systematically searched electronic databases for published and gray literature available from January 1, 2005 to April 11, 2019. Studies assessing an eHealth intervention that targeted any health condition and was designed for use by children, adolescents, and their parents were eligible for inclusion. eHealth interventions needed to be web-, computer-, or mobile-based, mediated by the internet with some degree of interactivity. Studies were also required to report the measurement of ‘user experience’ as first-person experiences, involving cognitive and behavioural factors, reported by intervention users. Two reviewers independently screened studies for relevance and appraised the quality of user experience measures using published criteria: ‘well-established’, ‘approaching well-established’, ‘promising’, or ‘not yet established’. We conducted a descriptive analysis of how user experience was defined and measured in each study. Review findings subsequently informed the survey questions used in the Delphi consultations with eHealth researchers and adolescent users for how user experience should be defined and measured. RESULTS Of the 8,634 articles screened for eligibility, 129 and one erratum were included in the review. Thirty eHealth researchers and 27 adolescents participated in the Delphi consultations. Based on the literature and consultations, we proposed working definitions for six main user experience domains: acceptability, satisfaction, credibility, usability, user-reported adherence, and perceived impact. While most studies incorporated a study-specific measure, we identified ten well-established measures to quantify five of the six domains of user experience (all except for self-reported adherence). Our adolescent and researcher participants ranked perceived impact as one of the most important domains of user experience and usability as one of the least important domains. Rankings between adolescents and researchers diverged for other domains. CONCLUSIONS Findings highlight the various ways user experience has been defined and measured across studies and what aspects are most valued by researchers and adolescent users. We propose incorporating the working definitions and available measures of user experience to support consistent evaluation and reporting of outcomes across studies. Future studies can refine the definitions and measurement of user experience, explore how user experience relates to other eHealth outcomes, and inform the design and use of human-centred eHealth interventions.


2018 ◽  
Author(s):  
Elvis Tichaona Munatswa ◽  
Mzikazi Nduna ◽  
Thobeka Nkomo ◽  
Esmeralda Vilanculos

Pain Medicine ◽  
2021 ◽  
Author(s):  
Daly Geagea ◽  
Zephanie Tyack ◽  
Roy Kimble ◽  
Lars Eriksson ◽  
Vince Polito ◽  
...  

Abstract Objective Inadequately treated pain and distress elicited by medical procedures can put children at higher risks of acute and chronic biopsychosocial sequelae. Children can benefit from hypnotherapy, a psychological tailored intervention, as an adjunct to pharmacological agents to address the multiple components of pain and distress. Despite providing evidence on the effectiveness and potential superiority of hypnotherapy to other psychological interventions, research on hypnotherapy for paediatric procedural pain and distress has been predominantly limited to oncology and needle procedures. Plus, there is a lack of reporting of intervention manuals, factors influencing hypnotic responding, pain unpleasantness outcomes, theoretical frameworks, adverse events, as well as barriers and facilitators to the feasibility of delivering the intervention and study procedures. The proposed review aims to map the range and nature of the evidence on hypnotherapy for procedural pain and distress in children to identify gaps in literature and areas requiring further investigation. Methods This review will follow the Arksey and O'Malley (2005) methodology and incorporate additional scoping review recommendations by The Joanna Briggs Institute and Preferred Reporting Items for Systematic reviews and Meta-Analyses. Relevant studies will be identified through searching published literature databases (PubMed, Cochrane Library, PsycINFO, Embase, CINAHL, Scopus and Web of Science) and grey literature in addition to hand-searching of reference lists and key journals. Two authors will independently screen titles and abstracts of search results followed by full-texts review against eligibility criteria. Conclusion Findings are anticipated to guide future research and inform the development of tailored hypnotic interventions in children.


BMJ Open ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. e040922
Author(s):  
Bethany Villas ◽  
Uira Duarte Wisnesky ◽  
Sandra Campbell ◽  
Lauren Slavik ◽  
Amynah S. Mevawala ◽  
...  

Review question/objectiveThe purpose of this proposed review is twofold: first, to understand the role of occupational therapy presented in the musicians’ health literature; and second, to explore the potential for this role.IntroductionThe intense movement, awkward postures, concentration and emotional communication required of musicians can place them at increased risk of music-related health conditions, such as musculoskeletal disorders and performance anxiety. The development of music-related health conditions can be emotionally and financially devastating. The role of occupational therapy in musicians’ health has been previously discussed; however, no rigorous reviews of the scholarly literature have been published. We will, therefore, undertake a scoping review with the following research questions: (1) what is known about the role of occupational therapy in instrumental musicians’ health? and (2) what is the potential role of occupational therapy in musicians’ health?Methods and analysisA preliminary search of Medline, CINAHL, SCOPUS and Web of Science was previously undertaken by the first author to determine the extent of the research on this topic and to confirm that no other reviews have been conducted or are in progress. Study selection and analysis will follow the Joanna Briggs Institute and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews guidelines for conducting a scoping review.Ethics and disseminationFormal ethics approval is not required at our institution for a review of published literature. The results of this review will be shared through peer-reviewed publications, conference presentations and traditional and social media.


2021 ◽  
Author(s):  
Rachel L. Leech ◽  
James Selfe ◽  
Suzanne Ball ◽  
Susan Greenhalgh ◽  
Gareth Hogan ◽  
...  

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