scholarly journals Is the p-Value a Suitable Basis for the Construction of Measures of Evidence? Comment on “The Role of p-Values in Judging the Strength of Evidence and Realistic Replication Expectations”

2020 ◽  
pp. 1-2
Author(s):  
Stefan Wellek ◽  
Maria Blettner
Keyword(s):  
P Value ◽  
P Values ◽  
Strength Of Evidence

scholarly journals The frequent insignificance of a “significant” P-value

2021 ◽  
Author(s):  
David McGiffin ◽  
Geoff Cumming ◽  
Paul Myles
Keyword(s):  
Diagnostic Tests ◽  
Null Hypothesis ◽  
Open Science ◽  
Significance Testing ◽  
P Value ◽  
Conditional Probabilities ◽  
Null Hypothesis Significance Testing ◽  
P Values ◽  
Science Practices ◽  
Strength Of Evidence

Null hypothesis significance testing (NHST) and p-values are widespread in the cardiac surgical literature but are frequently misunderstood and misused. The purpose of the review is to discuss major disadvantages of p-values and suggest alternatives. We describe diagnostic tests, the prosecutor’s fallacy in the courtroom, and NHST, which involve inter-related conditional probabilities, to help clarify the meaning of p-values, and discuss the enormous sampling variability, or unreliability, of p-values. Finally, we use a cardiac surgical database and simulations to explore further issues involving p-values. In clinical studies, p-values provide a poor summary of the observed treatment effect, whereas the three- number summary provided by effect estimates and confidence intervals is more informative and minimises over-interpretation of a “significant” result. P-values are an unreliable measure of strength of evidence; if used at all they give only, at best, a very rough guide to decision making. Researchers should adopt Open Science practices to improve the trustworthiness of research and, where possible, use estimation (three-number summaries) or other better techniques.

The Role of Bone Phosphorus, Calcium and Magnesium on Bone Reserves of Indigenous Mixed Breed Cattle Grazing Natural Pasture during Times of Mineral Stress Induced by Drought in Mogosane Village of North West Province, South Africa

2020 ◽  
Author(s):  
B. G. Mokolopi
Keyword(s):  
Specific Gravity ◽  
Cattle Grazing ◽  
Bone Volume ◽  
P Value ◽  
Bone Thickness ◽  
P Values ◽  
North West ◽  
Natural Pasture ◽  
Calcium And Magnesium

Background: Bone consists of Ca and P deposited within an organic collagen matrix. The highly porous nature of this matrix provides bone with an extensive surface area, making bone a highly labile source of both Ca and P and serves as metabolic reservoir for Ca, P and other minerals. Phosphorus in the skeleton provides large reserve, which may be mobilized when the diet is deficient in phosphorus, the measurement of bone minerals is important to evaluate bone reserves such as bone volume, bone specific gravity and bone thickness. Methods: Ten male mix breed cattle between the ages of 6 and 12 months therefore, were randomly selected from a herd feeding exclusively on communal grazing and receiving no supplements and were used to determine the role of bone phosphorus, calcium and magnesium on bone reserves in cattle grazing natural pasture. Bone samples were analysed for P through the FASPac II Version R2MI Auto- Analyzer and were analysed for Ca and Mg through an Atomic Absorption Spectrometer. Results: Bone volume, bone specific gravity and bone thickness were reacting with same pattern almost throughout research. Grass phosphorus was positively correlated to bone Mg (r2= 0.466) with the P value of 0.053. Concentration of Ca in the grass was positively correlated to bone Mg (r2= 0.524) and bone specific gravity (r2= 0.593) with the P values of 0.051 and 0.048 respectively. The rainfall measured during the research shown to have positive correlation on the concentration of P in the grass r2= 0.690) and of Mg (r2= 0.848) with the P values of 0.04 and 0.001 respectively.

scholarly journals ROLE OF OCTREOTIDE ON OUTCOME OF PATIENTS WITH ACUTE PANCREATITIS

1969 ◽  
Vol 5 (1) ◽  
pp. 639-643
Author(s):  
AJMAL KHAN ◽  
SAMIULLAH ◽  
MANZOOR ALI ◽  
SAIFUREHMAN
Keyword(s):  
Acute Pancreatitis ◽  
Hospital Stay ◽  
Pain Control ◽  
Tertiary Care ◽  
P Value ◽  
Care Hospital ◽  
P Values ◽  
Group A ◽  
Group B

BACKGROUND: acute pancreatitis is a multisystem disease carrying broad spectrum of clinicalpresentation and complications. The objective of this study was to determine the positive role ofoctreotide in the out come of patients suffering from acute pancreatitis.OBJECTIVE: The objective of this study was to assess the role of octreotide in patients having acutepancreatitis.PATIENTS AND METHODS: This is a descriptive, comparative, prospective study. The study wasconducted in the department of surgery Saidu Group of Teaching hospital Saidu Sharif Swat fromJanuary 2011 to June 2014. Total of seventy consecutive patients having acute pancreatitis wasrandomized in a prospective trail for the treatment, at tertiary care hospital in Malakand division SwatKPK Pakistan. The data of patients were recorded on a purposely prepared proforma for this study. Thediagnosis of patients was established on basis of biochemical (serum amylase, WCC, C-reactive protein)and radiological (USG, CT- scan) investigations. The patients were divided into two groups, A and B.Group A, had received octreotide along with fluids, omeprazole, analgesic. Group B received fluids,omeprazole, analgesic without octreotide. Ages of the Group A and B were matched (±5 years). Datawas analyzed using SPSS version 16 employing chi-square test (X" test). A p-value below 0.05 wasconsidered statistically significant.RESULTS: In this prospective, comparative study two groups, each of 35 consecutive patients wereselected. The mean age in Group A was 37 ±12.41 years and in Group B 40±10.32 years (p DO.364).There were 12 males and 23 females in group A, while 14 males and 21 females in group B. Both thegroups were comparable. All the patients in octreotide group A and non-octreotide group B weresurvived. No major complications were noted in either group. As far as mean hospital stay was 7 ±2.10days in group A, while it was 9±3.14 days in group B (p<0.032). All the P- values for the criteria ofstudy were calculated. P-values were significant when we consider pain control and hospital stay intwo groups.CONCLUSION: In our study we found that octreotide was more effective in the final outcome ofpatients with acute pancreatitis. There is clear cut beneficial effect of octreotide on hospital stay andreduced need of analgesics in patients having acute pancreatitis.KEYWORDS: Acute Pancreatitis, Octreotide, Hospital Stay, pain control.

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