The Role of Bone Phosphorus, Calcium and Magnesium on Bone Reserves of Indigenous Mixed Breed Cattle Grazing Natural Pasture during Times of Mineral Stress Induced by Drought in Mogosane Village of North West Province, South Africa

2020 ◽  
Author(s):  
B. G. Mokolopi
Keyword(s):  
Specific Gravity ◽  
Cattle Grazing ◽  
Bone Volume ◽  
P Value ◽  
Bone Thickness ◽  
P Values ◽  
North West ◽  
Natural Pasture ◽  
Calcium And Magnesium

Background: Bone consists of Ca and P deposited within an organic collagen matrix. The highly porous nature of this matrix provides bone with an extensive surface area, making bone a highly labile source of both Ca and P and serves as metabolic reservoir for Ca, P and other minerals. Phosphorus in the skeleton provides large reserve, which may be mobilized when the diet is deficient in phosphorus, the measurement of bone minerals is important to evaluate bone reserves such as bone volume, bone specific gravity and bone thickness. Methods: Ten male mix breed cattle between the ages of 6 and 12 months therefore, were randomly selected from a herd feeding exclusively on communal grazing and receiving no supplements and were used to determine the role of bone phosphorus, calcium and magnesium on bone reserves in cattle grazing natural pasture. Bone samples were analysed for P through the FASPac II Version R2MI Auto- Analyzer and were analysed for Ca and Mg through an Atomic Absorption Spectrometer. Results: Bone volume, bone specific gravity and bone thickness were reacting with same pattern almost throughout research. Grass phosphorus was positively correlated to bone Mg (r2= 0.466) with the P value of 0.053. Concentration of Ca in the grass was positively correlated to bone Mg (r2= 0.524) and bone specific gravity (r2= 0.593) with the P values of 0.051 and 0.048 respectively. The rainfall measured during the research shown to have positive correlation on the concentration of P in the grass r2= 0.690) and of Mg (r2= 0.848) with the P values of 0.04 and 0.001 respectively.

scholarly journals ROLE OF OCTREOTIDE ON OUTCOME OF PATIENTS WITH ACUTE PANCREATITIS

1969 ◽  
Vol 5 (1) ◽  
pp. 639-643
Author(s):  
AJMAL KHAN ◽  
SAMIULLAH ◽  
MANZOOR ALI ◽  
SAIFUREHMAN
Keyword(s):  
Acute Pancreatitis ◽  
Hospital Stay ◽  
Pain Control ◽  
Tertiary Care ◽  
P Value ◽  
Care Hospital ◽  
P Values ◽  
Group A ◽  
Group B

BACKGROUND: acute pancreatitis is a multisystem disease carrying broad spectrum of clinicalpresentation and complications. The objective of this study was to determine the positive role ofoctreotide in the out come of patients suffering from acute pancreatitis.OBJECTIVE: The objective of this study was to assess the role of octreotide in patients having acutepancreatitis.PATIENTS AND METHODS: This is a descriptive, comparative, prospective study. The study wasconducted in the department of surgery Saidu Group of Teaching hospital Saidu Sharif Swat fromJanuary 2011 to June 2014. Total of seventy consecutive patients having acute pancreatitis wasrandomized in a prospective trail for the treatment, at tertiary care hospital in Malakand division SwatKPK Pakistan. The data of patients were recorded on a purposely prepared proforma for this study. Thediagnosis of patients was established on basis of biochemical (serum amylase, WCC, C-reactive protein)and radiological (USG, CT- scan) investigations. The patients were divided into two groups, A and B.Group A, had received octreotide along with fluids, omeprazole, analgesic. Group B received fluids,omeprazole, analgesic without octreotide. Ages of the Group A and B were matched (±5 years). Datawas analyzed using SPSS version 16 employing chi-square test (X" test). A p-value below 0.05 wasconsidered statistically significant.RESULTS: In this prospective, comparative study two groups, each of 35 consecutive patients wereselected. The mean age in Group A was 37 ±12.41 years and in Group B 40±10.32 years (p DO.364).There were 12 males and 23 females in group A, while 14 males and 21 females in group B. Both thegroups were comparable. All the patients in octreotide group A and non-octreotide group B weresurvived. No major complications were noted in either group. As far as mean hospital stay was 7 ±2.10days in group A, while it was 9±3.14 days in group B (p<0.032). All the P- values for the criteria ofstudy were calculated. P-values were significant when we consider pain control and hospital stay intwo groups.CONCLUSION: In our study we found that octreotide was more effective in the final outcome ofpatients with acute pancreatitis. There is clear cut beneficial effect of octreotide on hospital stay andreduced need of analgesics in patients having acute pancreatitis.KEYWORDS: Acute Pancreatitis, Octreotide, Hospital Stay, pain control.

scholarly journals Kinematic and Microphysical Significance of Lightning Jumps versus Nonjump Increases in Total Flash Rate

2017 ◽  
Vol 32 (1) ◽  
pp. 275-288 ◽  
Author(s):  
Christopher J. Schultz ◽  
Lawrence D. Carey ◽  
Elise V. Schultz ◽  
Richard J. Blakeslee
Keyword(s):  
Severe Weather ◽  
Mixed Phase ◽  
Mass Change ◽  
P Value ◽  
P Values ◽  
Significance Level ◽  
Flash Rate ◽  
Total Lightning ◽  
Two Parameters

Abstract Thirty-nine thunderstorms are examined using multiple-Doppler, polarimetric, and total lightning observations to understand the role of mixed-phase kinematics and microphysics in the development of lightning jumps. This sample size is larger than those of previous studies on this topic. The principal result of this study is that lightning jumps are a result of mixed-phase updraft intensification. Larger increases in intense updraft volume (≥10 m s−1) and larger changes in peak updraft speed are observed prior to lightning jump occurrence when compared to other nonjump increases in total flash rate. Wilcoxon–Mann–Whitney rank sum testing yields p values ≤ 0.05, indicating statistical independence between lightning jump and nonjump distributions for these two parameters. Similar changes in mixed-phase graupel mass magnitude are observed prior to lightning jumps and nonjump increases in total flash rate. The p value for the graupel mass change is p = 0.096, so jump and nonjump distributions for the graupel mass change are not found to be statistically independent using the p = 0.05 significance level. The timing of updraft volume, speed, and graupel mass increases is found to be 4–13 min in advance of lightning jump occurrence. Also, severe storms without lightning jumps lack robust mixed-phase updrafts, demonstrating that mixed-phase updrafts are not always a requirement for severe weather occurrence. Therefore, the results of this study show that lightning jump occurrences are coincident with larger increases in intense mixed-phase updraft volume and peak updraft speed than smaller nonjump increases in total flash rate.

scholarly journals Relationship between Continuity of Care in the Multidisciplinary Treatment of Patients with Diabetes and Their Clinical Results

2019 ◽  
Vol 9 (2) ◽  
pp. 268 ◽  
Author(s):  
Cecilia Saint-Pierre ◽  
Florencia Prieto ◽  
Valeria Herskovic ◽  
Marcos Sepúlveda
Keyword(s):  
Metabolic Control ◽  
Continuity Of Care ◽  
Multidisciplinary Treatment ◽  
Clinical Results ◽  
P Value ◽  
Diabetic Patients ◽  
P Values ◽  
Patients With Diabetes ◽  
Sequential Continuity

Multidisciplinary treatment and continuity of care throughout treatment are important for ensuring metabolic control and avoiding complications in diabetic patients. This study examines the relationship between continuity of care of the treating disciplines and clinical evolution of patients. Data from 1836 adult patients experiencing type 2 diabetes mellitus were analyzed, in a period between 12 and 24 months. Continuity was measured by using four well known indices: Usual Provider Continuity (UPC), Continuity of Care Index (COCI), Herfindahl Index (HI), and Sequential Continuity (SECON). Patients were divided into five segments according to metabolic control: well-controlled, worsened, moderately decompensated, highly decompensated, and improved. Well-controlled patients had higher continuity by physicians according to UPC and HI indices (p-values 0.029 and <0.003), whereas highly decompensated patients had less continuity in HI (p-value 0.020). Continuity for nurses was similar, with a greater continuity among well-controlled patients (p-values 0.015 and 0.001 for UPC and HI indices), and less among highly decompensated patients (p-values 0.004 and <0.001 for UPC and HI indices). Improved patients had greater adherence to the protocol than those who worsened. The SECON index showed no significant differences across the disciplines. This study identified a relationship between physicians and nurse’s continuity of care and metabolic control in patients with diabetes, consistent with qualitative findings that highlight the role of nurses in treatment.

scholarly journals Prognostic role of microRNA 182 and microRNA 18a in locally advanced triple negative breast cancer

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0242190
Author(s):  
Rajat Bajaj ◽  
Rupal Tripathi ◽  
T. S. Sridhar ◽  
Aruna Korlimarla ◽  
Kumardeep Dutta Choudhury ◽  
...  
Keyword(s):  
Survival Data ◽  
Tumor Size ◽  
Triple Negative ◽  
Menopausal Status ◽  
Locally Advanced ◽  
Nodal Status ◽  
P Value ◽  
P Values ◽  
T Category

Background The study assessed the epigenetic regulation and the role of microRNA (miR) expression in locally advanced triple negative breast cancers (TNBC) and comparison with the clinico-pathological variables and survival. Methods Fifty patients of locally advanced TNBC during the period 2011–2013 were included. Expression level of test microRNA (miR-182 and miR-18a) was determined using Taqman quantitative Real time polymerase chain reaction (qRT-PCR) from formalin fixed paraffin embedded biopsy blocks. Clinical and demographic information and survival data was retrieved from the Hospital medical records. Results An improved clinical complete response (cCR) was observed in patients with age ≥ 45 years (80%), premenopausal status (70%), tumor size < 6 cms (80%), nodal status N0-N1 (95%) and grade II-III tumor (80%). A statistically significant correlation was observed on comparison of cCR with menopausal status (p-value 0.020), T category (p-value 0.018) and the clinical nodal status (p-value 0.003). pCR also correlated with clinical nodal status (p-value 0.008). Epigenetically, miR-18a under expression (< 8.84) was most commonly associated with tumor size < 6 cms (76.7%), clinical nodal status N0-N1 (90%), cCR (60%) and pCR (53.3%). A similar trend was observed with miR-182. Statistical significance was observed with T category (p-values 0.003 and 0.004), clinical nodal status (p-values 0.001 and 0.001), clinical response (p-values 0.002 and 0.002) and pathological response (p-values 0.007 and 0.006) with respect to miR-18a and miR-182, respectively. Also, the menopausal status significantly correlated with the miR-182 expression (p-value 0.009). miR-182 overexpression (≥ 6.32) was not observed in any of the postmenopausal patients. A univariate cox proportional hazard regression model also showed statistical interactions (p-values <0.004). Conclusion miR-182 and miR-18a overexpression correlates with worse clinical and pathological tumor characteristics in locally advanced TNBC and hence could be used to predict the outcomes and prognosis in these patients.

scholarly journals S19. THE ROLE OF ACE AS POSSIBLE BIOMARKER FOR TREATMENT RESISTANCE TO ANTIPSYCHOTICS IN FIRST EPISODE OF PSYCHOSIS

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S37-S37
Author(s):  
Longo Luisa ◽  
Akira Sawa
Keyword(s):  
Cognitive Performance ◽  
Treatment Resistance ◽  
First Episode ◽  
Blood Levels ◽  
P Value ◽  
Treatment Resistant ◽  
Angiotensin I ◽  
P Values ◽  
Csf Levels

Abstract Background Angiotensin I–converting enzyme (ACE) is a peptidase that converts angiotensin I into the vasoactive and aldosterone-stimulating peptide angiotensin II, a key protein in controlling blood pressure. Recently, several evidences have shown a role of ACE in psychosis. However, the role of ACE in psychosis is poorly characterized, and at last unknown. In this study we hypothesized that ACE blood and CSF levels are lower in patients at first episode of psychosis (FEP) compared to controls; that blood ACE levels can predict the response to antipsychotics; that low plasma ACE levels correlate with both severity of symptoms and cognitive performance. Methods This research used data from a longitudinal cohort study of FEP (N = 138) and controls (N = 115). First of all, we conducted a two-group comparison analyses to assess the differences between patients and controls in terms of ACE levels in both blood and CSF. As a second step, we divided our patients into treatment resistant (TR) and not treatment resistant t(non-TR) to investigate ACE blood levels in these two group. Finally, we evaluated the association between ACE blood levels and clinical phenotype and neurocognition. Results Two-group analyses showed lower levels of ACE in patients than controls, both in blood and CSF (p values&lt; 0.05). The two-group analyses between TR and non-TR showed lower ACE blood levels in TRs compared to non-TRs (p value&lt; 0.05). Finally, multiple regressions showed a continuous relationship between cognitive performance and ACE blood levels (p values &lt; 0.05). Discussion In conclusion, these findings showed that those FEP with lower ACE blood levels were not only more likely to develop TR conditions, but they also had greater cognitive impairment. These results are very promising, as they suggest that ACE levels can be used as a peripheral biomarker to stratify patients at first episode of psychosis.

scholarly journals Role of Visfatin as a Marker for Depression in Elderly Patients

2020 ◽  
Vol 10 (3) ◽  
pp. 215-218
Author(s):  
Sabeen Qazi ◽  
Shaista Emad ◽  
Rubina Ghani
Keyword(s):  
Blood Pressure ◽  
Old Age ◽  
Case Control Study ◽  
Serum Triglyceride ◽  
The Elderly ◽  
P Value ◽  
P Values ◽  
The City ◽  
Control Study

Objective: To identify a new marker for depression amongst the elderly residing in old age institutes (OAI) of Karachi. Study Design and Setting: This was a case control study which was carried out by visiting different private old age institutions in the city of Karachi, Pakistan from 2017- 2018. Methodology: A total of 164 people aged 60 years or more were enrolled via convenient sampling. Basic anthropometric variables were measured, lipid profile was estimated as well as serum Visfatin was estimated via ELISA and was also estimated. Results: The BMI, serum triglyceride and visfatin in depressed subjects were significant with p values < 0.001 **, < 0.004* and < 0.001* respectively. Systolic blood pressure was highly significant in depressed subjects when compared with control cases p value < 0.000**.The diastolic blood pressure was significant p value < 0.001* as well. Visfatin was found to be negatively correlated with triglycerides, BMI and LDL and it was weakly correlated with depression. Conclusion: The levels of visfatin were found raised in the depressed individuals but they were statistically not significant. It is suggested that more studies on visfatin can be done to find its association in the identification of depressive symptoms in patients suffering from depression.

The Estimation of prostate specific antigen (PSA) concentrations in patients with prostatitis by fully automated ELISA technique.

2020 ◽  
Vol 3 (11) ◽  
pp. 1100-1104
Author(s):  
Hussein Naeem Aldhaheri ◽  
Ihsan Edan AlSaimary ◽  
Murtadha Mohammed ALMusafer
Keyword(s):  
Personal Information ◽  
Receptor Gene ◽  
Specific Antigen ◽  
Gene Clusters ◽  
Control Group ◽  
P Value ◽  
Group Data ◽  
Elisa Technique ◽  
And Control

      The Aim of this study was to determine Immunogenetic expression of  Toll-like receptor gene clusters related to prostatitis, to give acknowledge about Role of TLR in prostatitis immunity in men from Basrah and Maysan provinces. A case–control study included 135 confirmed prostatitis patients And 50 persons as a control group. Data about age, marital status, working, infertility, family history and personal information like (Infection, Allergy, Steroid therapy, Residency, Smoking, Alcohol Drinking, Blood group, Body max index (BMI) and the clinical finding for all patients of Prostatitis were collected. This study shows the effect of PSA level in patients with prostatitis and control group, with P-value <0.0001 therefore the study shows a positive significant between elevated PSA levels and Prostatitis.

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