scholarly journals Effects of vitamin D supplementation on carotid intima-media thickness in HIV-infected youth

Virulence ◽  
2017 ◽  
Vol 9 (1) ◽  
pp. 294-305 ◽  
Author(s):  
Allison Ross Eckard ◽  
Paolo Raggi ◽  
Mary Ann O'Riordan ◽  
Julia C. Rosebush ◽  
Danielle Labbato ◽  
...  
Keyword(s):  
Vitamin D ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Vitamin D Supplementation ◽  
Media Thickness ◽  
Hiv Infected Youth

Serum Vitamin D Level and Carotid Intima-Media Thickness: A Systematic Review and Meta-Analysis of Observational Studies and Randomized Control Trials

2020 ◽  
Vol 52 (05) ◽  
pp. 305-315
Author(s):  
Nasim Säidifard ◽  
Hadith Tangestani ◽  
Kurosh Djafarian ◽  
Sakineh Shab-Bidar
Keyword(s):  
Vitamin D ◽  
Observational Studies ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Vitamin D Supplementation ◽  
Inverse Association ◽  
Serum Vitamin D ◽  
Media Thickness

AbstractIt is reported that vitamin D deficiency is associated with carotid intima-media thickness (CIMT). In addition, several randomized clinical trials (RCTs) have studied the influence of vitamin D supplement on CIMT. However, results are inconclusive. This review aimed to systematically explore the potential link of the serum vitamin D level with CIMT pooling together observational studies and RCTs. PubMed and Scopus were searched for studies published until February 13, 2018. The Fisher’s z (SE) correlation coefficient, odds ratio (OR), and mean (SD) of changes in CIMT from baseline were used to perform meta-analysis in observational studies and RCTs, respectively. To pool data, both a fixed-effects model and a random-effects model (in case of heterogeneity) were used. Heterogeneity was assessed using Cochran’s Q and I2 tests. Nineteen observational studies and 3 RCTs met inclusion criteria. The pooled correlation coefficients of 17 observational studies showed [(Fisher’s z=− 0.41, 95% CI: –0.63 to –0.19, p<0.001), I2=96.9%, p < 0.001] a significant inverse association between serum vitamin D and risk of CIMT. Pooling three risk estimates of three studies [(OR = 1.69, 95% CI: 0.74 to 3.86, p=0.209); I2=085.1%, p<0.001)] indicated no significant association between serum vitamin D status and risk of CIMT. Combining data of RCTs showed vitamin D supplementation significantly reduced CIMT [(MD: –0.034, 95% CI: –0.62 to –0.05, p=0.012), I2=16.6%, p = 0.301]. Our findings show that serum vitamin D is inversely associated with CIMT and vitamin D supplementation may reduce CMIT.

scholarly journals Vitamin D and progression of carotid intima-media thickness in HIV-positive Canadians

HIV Medicine ◽  
2017 ◽  
Vol 19 (2) ◽  
pp. 143-151 ◽  
Author(s):  
H Huff ◽  
AT Merchant ◽  
E Lonn ◽  
E Pullenayegum ◽  
F Smaill ◽  
...  
Keyword(s):  
Vitamin D ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Hiv Positive ◽  
Media Thickness

scholarly journals Association of Vitamin D Insufficiency with Carotid Intima-Media Thickness in HIV-Infected Persons

2011 ◽  
Vol 52 (7) ◽  
pp. 941-944 ◽  
Author(s):  
Andy I. Choi ◽  
Joan C. Lo ◽  
Kathleen Mulligan ◽  
Amanda Schnell ◽  
S. Craig Kalapus ◽  
...  
Keyword(s):  
Vitamin D ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Vitamin D Insufficiency ◽  
Media Thickness

scholarly journals The effects of vitamin D, K and calcium co-supplementation on carotid intima-media thickness and metabolic status in overweight type 2 diabetic patients with CHD

2016 ◽  
Vol 116 (2) ◽  
pp. 286-293 ◽  
Author(s):  
Zatollah Asemi ◽  
Fariba Raygan ◽  
Fereshteh Bahmani ◽  
Zohreh Rezavandi ◽  
Hamid Reza Talari ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cell Function ◽  
Controlled Trial ◽  
Serum Vitamin ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Metabolic Status ◽  
Diabetic Patients ◽  
Serum Vitamin D ◽  
Media Thickness

AbstractThis study was conducted to examine the effects of vitamin D, K and Ca co-supplementation on carotid intima-media thickness (CIMT) and metabolic status in overweight diabetic patients with CHD. This randomised, double-blind, placebo-controlled trial was conducted among sixty-six diabetic patients with CHD. Participants were randomly allocated into two groups to take either 5µg vitamin D, 90 µg vitamin K plus 500 mg Ca supplements (n 33) or placebo (n 33) twice a day for 12 weeks. Fasting blood samples were obtained at the beginning of the study and after the 12-week intervention period to determine related markers. Vitamin D, K and Ca co-supplementation resulted in a significant reduction in maximum levels of left CIMT (−0·04 (sd 0·22) v. +0·04 (sd 0·09) mm, P=0·02). Changes in serum vitamin D (+6·5 (sd 7·8) v. +0·4 (sd 2·2) ng/ml, P<0·001), Ca (+0·6 (sd 0·3) v. +0·1 (sd 0·1) mg/dl, P<0·001) and insulin concentrations (−0·9 (sd 3·1) v. +2·6 (sd 7·2) µIU/ml, P=0·01), homoeostasis model for assessment of estimated insulin resistance (−0·4 (sd 1·2) v. +0·7 (sd 2·3), P=0·01), β-cell function (−2·1 (sd 9·0) v. +8·9 (sd 23·7), P=0·01) and quantitative insulin sensitivity check index (+0·007 (sd 0·01) v. −0·006 (sd 0·02), P=0·01) in supplemented patients were significantly different from those in patients in the placebo group. Supplementation resulted in significant changes in HDL-cholesterol (+2·7 (sd 7·0) v. −2·5 (sd 5·7) mg/dl, P=0·002), high-sensitivity C-reactive protein (−1320·1 (sd 3758·3) v. +464·0 (sd 3053·3) ng/ml, P=0·03) and plasma malondialdehyde concentrations (−0·4 (sd 0·5) v. −1·0 (sd 1·1) µmol/l, P=0·007) compared with placebo. Overall, vitamin D, K and Ca co-supplementation for 12 weeks among diabetic patients with CHD had beneficial effects on maximum levels of left CIMT and metabolic status. The effect of vitamin D, K and Ca co-supplementation on maximum levels of left CIMT could be a chance finding.

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