scholarly journals Inverse Association of Serum Vitamin D in Relation to Carotid Intima-Media Thickness in Chinese Postmenopausal Women

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0122803 ◽  
Author(s):  
Yaping Hao ◽  
Xiaojing Ma ◽  
Yuqi Luo ◽  
Yiting Xu ◽  
Qin Xiong ◽  
...  
Keyword(s):  
Vitamin D ◽  
Postmenopausal Women ◽  
Serum Vitamin ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Inverse Association ◽  
Serum Vitamin D ◽  
Media Thickness ◽  
Chinese Postmenopausal Women

Serum Vitamin D Level and Carotid Intima-Media Thickness: A Systematic Review and Meta-Analysis of Observational Studies and Randomized Control Trials

2020 ◽  
Vol 52 (05) ◽  
pp. 305-315
Author(s):  
Nasim Säidifard ◽  
Hadith Tangestani ◽  
Kurosh Djafarian ◽  
Sakineh Shab-Bidar
Keyword(s):  
Vitamin D ◽  
Observational Studies ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Vitamin D Supplementation ◽  
Inverse Association ◽  
Serum Vitamin D ◽  
Media Thickness

AbstractIt is reported that vitamin D deficiency is associated with carotid intima-media thickness (CIMT). In addition, several randomized clinical trials (RCTs) have studied the influence of vitamin D supplement on CIMT. However, results are inconclusive. This review aimed to systematically explore the potential link of the serum vitamin D level with CIMT pooling together observational studies and RCTs. PubMed and Scopus were searched for studies published until February 13, 2018. The Fisher’s z (SE) correlation coefficient, odds ratio (OR), and mean (SD) of changes in CIMT from baseline were used to perform meta-analysis in observational studies and RCTs, respectively. To pool data, both a fixed-effects model and a random-effects model (in case of heterogeneity) were used. Heterogeneity was assessed using Cochran’s Q and I2 tests. Nineteen observational studies and 3 RCTs met inclusion criteria. The pooled correlation coefficients of 17 observational studies showed [(Fisher’s z=− 0.41, 95% CI: –0.63 to –0.19, p<0.001), I2=96.9%, p < 0.001] a significant inverse association between serum vitamin D and risk of CIMT. Pooling three risk estimates of three studies [(OR = 1.69, 95% CI: 0.74 to 3.86, p=0.209); I2=085.1%, p<0.001)] indicated no significant association between serum vitamin D status and risk of CIMT. Combining data of RCTs showed vitamin D supplementation significantly reduced CIMT [(MD: –0.034, 95% CI: –0.62 to –0.05, p=0.012), I2=16.6%, p = 0.301]. Our findings show that serum vitamin D is inversely associated with CIMT and vitamin D supplementation may reduce CMIT.

scholarly journals The effects of vitamin D, K and calcium co-supplementation on carotid intima-media thickness and metabolic status in overweight type 2 diabetic patients with CHD

2016 ◽  
Vol 116 (2) ◽  
pp. 286-293 ◽  
Author(s):  
Zatollah Asemi ◽  
Fariba Raygan ◽  
Fereshteh Bahmani ◽  
Zohreh Rezavandi ◽  
Hamid Reza Talari ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cell Function ◽  
Controlled Trial ◽  
Serum Vitamin ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Metabolic Status ◽  
Diabetic Patients ◽  
Serum Vitamin D ◽  
Media Thickness

AbstractThis study was conducted to examine the effects of vitamin D, K and Ca co-supplementation on carotid intima-media thickness (CIMT) and metabolic status in overweight diabetic patients with CHD. This randomised, double-blind, placebo-controlled trial was conducted among sixty-six diabetic patients with CHD. Participants were randomly allocated into two groups to take either 5µg vitamin D, 90 µg vitamin K plus 500 mg Ca supplements (n 33) or placebo (n 33) twice a day for 12 weeks. Fasting blood samples were obtained at the beginning of the study and after the 12-week intervention period to determine related markers. Vitamin D, K and Ca co-supplementation resulted in a significant reduction in maximum levels of left CIMT (−0·04 (sd 0·22) v. +0·04 (sd 0·09) mm, P=0·02). Changes in serum vitamin D (+6·5 (sd 7·8) v. +0·4 (sd 2·2) ng/ml, P<0·001), Ca (+0·6 (sd 0·3) v. +0·1 (sd 0·1) mg/dl, P<0·001) and insulin concentrations (−0·9 (sd 3·1) v. +2·6 (sd 7·2) µIU/ml, P=0·01), homoeostasis model for assessment of estimated insulin resistance (−0·4 (sd 1·2) v. +0·7 (sd 2·3), P=0·01), β-cell function (−2·1 (sd 9·0) v. +8·9 (sd 23·7), P=0·01) and quantitative insulin sensitivity check index (+0·007 (sd 0·01) v. −0·006 (sd 0·02), P=0·01) in supplemented patients were significantly different from those in patients in the placebo group. Supplementation resulted in significant changes in HDL-cholesterol (+2·7 (sd 7·0) v. −2·5 (sd 5·7) mg/dl, P=0·002), high-sensitivity C-reactive protein (−1320·1 (sd 3758·3) v. +464·0 (sd 3053·3) ng/ml, P=0·03) and plasma malondialdehyde concentrations (−0·4 (sd 0·5) v. −1·0 (sd 1·1) µmol/l, P=0·007) compared with placebo. Overall, vitamin D, K and Ca co-supplementation for 12 weeks among diabetic patients with CHD had beneficial effects on maximum levels of left CIMT and metabolic status. The effect of vitamin D, K and Ca co-supplementation on maximum levels of left CIMT could be a chance finding.

scholarly journals Serum vitamin D level and carotid artery intima-media thickness in CVA infarct patients as a marker of atherosclerosis

2015 ◽  
Vol 67 ◽  
pp. S121
Author(s):  
Rohit Rai ◽  
A. Lalchandani ◽  
Vivudh Singh ◽  
Senthilraj ◽  
M. Godara ◽  
...  
Keyword(s):  
Vitamin D ◽  
Carotid Artery ◽  
Serum Vitamin ◽  
Intima Media Thickness ◽  
Serum Vitamin D ◽  
Media Thickness

scholarly journals Variants Translating Reduced Expression of the Beta Estrogen Receptor Gene Were Associated With Increased Carotid Intima Media Thickness. A Cross-Sectional Study in Late Postmenopausal Women.

2020 ◽  
Author(s):  
Antonio-Jorge Cano-Marquina ◽  
Miguel-Ángel García-Pérez ◽  
Juan J Tarín ◽  
Alicia M Maceira ◽  
Juan Cosín-Sales ◽  
...  
Keyword(s):  
Vitamin D ◽  
Postmenopausal Women ◽  
Multivariable Analysis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
University Hospital ◽  
Sectional Study ◽  
Genotype Combination ◽  
Media Thickness ◽  
Carotid Wall

Abstract Background There is debate on the role of estrogens in modulating the risk for atherosclerosis in women. Our purpose was to investigate whether the size of the estrogenic impact was independently associated with variation of carotid intima-media thickness (IMT) in healthy late postmenopausal women. The levels of circulating estrogens have been used in previous studies but the influence of SNPs of the estrogen receptors (ER) α and β has not been investigated.Methods We performed a crossed-sectional study of 91 women in a university hospital. We used a double approach in which, in addition to the measurement of estradiol levels by ultrasensitive methods, genetic variants (SNPs) associated with differing expression of the ER α and β genes were assessed. Multivariable analysis was used to examine the association of candidate factors with the value of IMT and plaque detection at both the carotid wall and the sinus.Results The levels of glucose were directly associated with IMT at both the carotid wall (p<0.001) and the sinus (p=0.001), while age was positively associated with IMT at the sinus (p=0.003) and vitamin D with IMT at the carotid wall (P=0.035). A genotype combination translating reduced gene expression of the ERβ was directly associated with IMT at both the carotid wall (p=0.001) and the sinus (p=0.002).Conclusions Poorer estrogenic impact, as concordant with a SNP variant imposing reduced expression of the ERβ, was directly associated with IMT at both the carotid wall and the sinus. Glucose level, vitamin D only for the carotid wall, and age only for the sinus, also emerged as independent factors in the IMT variance.

P7.12 PULSE PRESSURE AND INTIMA MEDIA THICKNESS IN RELATION TO SERUM VITAMIN D CONCENTRATION IN A SAMPLE OF GENERAL POPULATION

2015 ◽  
Vol 12 (C) ◽  
pp. 32
Author(s):  
Agata Franczyk* ◽  
Katarzyna Stolarz-Skrzypek ◽  
Agnieszka Olszanecka ◽  
Wiktoria Wojciechowska ◽  
Anna Wesoαowska ◽  
...  
Keyword(s):  
Vitamin D ◽  
General Population ◽  
Pulse Pressure ◽  
Serum Vitamin ◽  
Intima Media Thickness ◽  
Serum Vitamin D ◽  
Media Thickness

scholarly journals The association between serum 25-hydroxyvitamin D level and subclinical atherosclerosis in healthy population

2020 ◽  
Author(s):  
Vida Mohammadzadeh ◽  
Masoud Mehrpour ◽  
Abdoreza Ghoreishi ◽  
Koorosh Kamali ◽  
Babak Zamani
Keyword(s):  
Vitamin D ◽  
Cardiovascular Risk ◽  
Vitamin D Deficiency ◽  
Subclinical Atherosclerosis ◽  
Serum Vitamin ◽  
Intima Media Thickness ◽  
Serum Vitamin D ◽  
Severe Vitamin ◽  
Media Thickness ◽  
History Of

Background: Subclinical atherosclerosis is the asymptomatic phase of carotid atherosclerosis, and its early diagnosis is important to prevent cerebrovascular diseases. Although the vitamin D plays a role in the structure of vessels, the association between the serum level of vitamin D and subclinical atherosclerosis has not been well-studied. We aimed to investigate the association between serum vitamin D level and carotid artery intima-media thickness (CIMT) in Iranian population. Methods: One hundred individuals with the age range from 20 to 50 years with no history of cardiovascular risk factors were selected for the analysis. Measurements of serum 25-hydroxyvitamin D3 [25(OH) D3] concentration and CIMT were made. Confounding factors such as diabetes, hypertension (HTN), smoking, alcohol, tobacco, dyslipidemia, cardiovascular disease (CVD), high body mass index (BMI), history of drug intake especially calcium, vitamin D, statins, and anti-hypertensive drugs were considered and then excluded from our study. Results: The mean serum vitamin D level was  15.55 ± 0.42 ng/ml, whereas in the increased intima-media thickness (IMT), it was 12.50 ± 9.50 ng/ml. 55% of the subjects were diagnosed with subclinical atherosclerosis (IMT ≥ 0.75 mm). Mean IMT was  0.74 ± 0.12 mm; however, it was higher (0.86 ± 0.30) in severe vitamin D deficiency group. The analysis showed an association between serum 25(OH) D3 level and CIMT (P = 0.002). 44% of those participants with subclinical atherosclerosis had also a severe vitamin D deficiency, while only 13% of normal people had a severe vitamin D deficiency. Also, a correlation was observed between severe vitamin D deficiency and the presence of plaque or higher IMT. Conclusion: Serum 25(OH) D3 level was inversely correlated with CIMT in our investigated subjects with no cardiovascular risk factor.

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