scholarly journals Intermolecular interactions involving an acidic patch on immunoglobulin variable domain and the γ2 constant region mediate crystalline inclusion body formation in the endoplasmic reticulum

2017 ◽  
Vol 7 (3) ◽  
pp. e1361499 ◽  
Author(s):  
Haruki Hasegawa ◽  
Mei Geng ◽  
Randal R. Ketchem ◽  
Ling Liu ◽  
Kevin Graham ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Inclusion Body ◽  
Intermolecular Interactions ◽  
Variable Domain ◽  
Crystalline Inclusion ◽  
Constant Region ◽  
Body Formation ◽  
Inclusion Body Formation

scholarly journals Zinc Attenuates the Cytotoxicity of Some Stimuli by Reducing Endoplasmic Reticulum Stress in Hepatocytes

2019 ◽  
Vol 20 (9) ◽  
pp. 2192 ◽  
Author(s):  
Masashi Kusanaga ◽  
Shinji Oe ◽  
Noriyoshi Ogino ◽  
Sota Minami ◽  
Koichiro Miyagawa ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Er Stress ◽  
Inclusion Body ◽  
Cultured Cells ◽  
Autophagic Flux ◽  
Body Formation ◽  
Excess Copper ◽  
Inclusion Body Formation ◽  
Cellular Integrity ◽  
Er Homeostasis

Zinc is an essential trace element and plays critical roles in cellular integrity and biological functions. Excess copper induced both oxidative stress and endoplasmic reticulum (ER) stress in liver-derived cultured cells. Excess copper also induced impairment of autophagic flux at the step of autophagosome–lysosome fusion, as well as Mallory–Denk body (MDB)-like inclusion body formation. Zinc ameliorated excess copper-induced impairment of autophagic flux and MDB-like inclusion body formation via the maintenance of ER homeostasis. Furthermore, zinc also ameliorated free fatty acid-induced impairment of autophagic flux. These results indicate that zinc may be able to protect hepatocytes from various ER stress-related conditions.

scholarly journals Specificity in intracellular protein aggregation and inclusion body formation

2001 ◽  
Vol 98 (23) ◽  
pp. 13060-13065 ◽  
Author(s):  
R. S. Rajan ◽  
M. E. Illing ◽  
N. F. Bence ◽  
R. R. Kopito
Keyword(s):  
Protein Aggregation ◽  
Inclusion Body ◽  
Intracellular Protein ◽  
Body Formation ◽  
Inclusion Body Formation

scholarly journals Different induction regimes in recombinant E. coli fed batch cultivations to modulate inclusion body formation, disassembly or prevention

2009 ◽  
Vol 25 ◽  
pp. S213
Author(s):  
M. Cserjan-Puschmann ◽  
M. Luchner ◽  
F. Clementschitsch ◽  
G. Striedner ◽  
K. Bayer
Keyword(s):  
Inclusion Body ◽  
Fed Batch ◽  
Body Formation ◽  
E Coli ◽  
Inclusion Body Formation
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