Long-term bumetanide administration altered behavioral pattern in mosaic Down’s Syndrome: A case report

2021 ◽  
pp. 1-8
Author(s):  
Zeinab Gharaylou ◽  
Lida Shafaghi ◽  
Seyed Khalil Pestehei ◽  
Mahmoudreza Hadjighassem
Keyword(s):  
Case Report ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Behavioral Pattern

The Use of 5-HTP in the Treatment of Down's Syndrome

PEDIATRICS ◽  
1974 ◽  
Vol 54 (2) ◽  
pp. 165-168
Author(s):  
Phillip Weise ◽  
Richard Koch ◽  
Kenneth N.F. Shaw ◽  
Martin J. Rosenfeld
Keyword(s):  
Down's Syndrome ◽  
Initial Dosage ◽  
Down’S Syndrome ◽  
Clinical Use ◽  
Developmental Quotient ◽  
Rate Of Development ◽  
The Difference ◽  
Age Category ◽  
Treatment Of Down's Syndrome

The clinical use of 5-HTP in the treatment of patients with Down's syndrome was reported by Bazelon and her colleagues in 1967. This approach appeared to offer the hope of improving subnormal development of children with this chromosomal defect. The rationale for the use of 5-HTP is related to its role as the natural biochemical precursor for serotonin (5-hydroxytryptamine). The blood level of this hormone is said to be decreased in Down's syndrome. The present study concerns 26 children with Down's syndrome who were treated with 5-HTP from early infancy until 3 to 4 years of age: 19 completed the course of treatment. DL-5-HTP was given orally with an initial dosage of 0.5 to 1.5 mg/kg/day. The dose was increased stepwise in 1 mg/kg/day increments to a maximum of 5 mg/kg/day. Children were seen by a clinic physician every 1 to 4 months and were assessed by a clinic psychologist every six months. The Gesell Test of Developmental Abilities was used to assess each child's level of development in terms of a total Developmental Quotient (DQ). The psychological findings were analyzed by applying a t test of the difference between independent mean DQs obtained for each age category. The results of this study indicate that long-term systematic use of 5-HTP is not effective in increasing the rate of development of Down's syndrome children.

scholarly journals Classic Gout in an adolescent with Down's syndrome. A Case Report

2021 ◽  
Author(s):  
Angela Luzia Branco Pinto Duarte ◽  
Carolina Dias da Silva Amorim ◽  
Amália Maria Fernandes de Sá Duarte Filha ◽  
Marco Felipe Macedo Alves ◽  
Tânia Caroline Castro ◽  
...  
Keyword(s):  
Case Report ◽  
Down's Syndrome ◽  
Down’S Syndrome

Down’s syndrome associated with absent patellae: A case report

1984 ◽  
Vol 51 (6) ◽  
pp. 729-731 ◽  
Author(s):  
D. S. Krishna Murthy ◽  
B. S. Prajapati ◽  
A. B. Desai
Keyword(s):  
Case Report ◽  
Down's Syndrome ◽  
Down’S Syndrome

Anorexia Nervosa in Down's Syndrome—A Case Report

1984 ◽  
Vol 145 (2) ◽  
pp. 195-196 ◽  
Author(s):  
D. J. Cottrell ◽  
A. H. Crisp
Keyword(s):  
Body Weight ◽  
Anorexia Nervosa ◽  
Case Report ◽  
Late Onset ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Treatment Programme ◽  
Grief Work ◽  
The Family ◽  
Normal Body Weight

SummaryA case is described of anorexia nervosa arising in a mentally-handicapped 35-year old person with Down's syndrome. The late onset is accounted for on the grounds that adolescent challenges had only recently arisen in this instance. Removal of the patient from the provocative situation, coupled with some effective psychotherapeutic ‘grief work’ with the family, was associated with restoration of normal body weight and menstrual function, following the patient's acceptance of the usual re-feeding treatment programme.

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