scholarly journals Natural killer cells contribute to enhanced respiratory disease after oil-in-water emulsion adjuvanted vaccination against respiratory syncytial virus and infection

2021 ◽  
pp. 1-12
Author(s):  
Yoonsuh Park ◽  
Ki-Hye Kim ◽  
Youri Lee ◽  
Young-Tae Lee ◽  
Sang-Moo Kang ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
Respiratory Disease ◽  
Killer Cells ◽  
Water Emulsion ◽  
Oil In Water ◽  
Syncytial Virus ◽  
Oil In Water Emulsion

scholarly journals Respiratory Syncytial Virus Infects Primary Neonatal and Adult Natural Killer Cells and Affects Their Antiviral Effector Function

2018 ◽  
Vol 219 (5) ◽  
pp. 723-733 ◽  
Author(s):  
Elisabeth A van Erp ◽  
Dorien Feyaerts ◽  
Maxime Duijst ◽  
H Lie Mulder ◽  
Oliver Wicht ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
Effector Function ◽  
Killer Cells ◽  
Syncytial Virus

scholarly journals Respiratory Syncytial Virus G and/or SH Protein Alters Th1 Cytokines, Natural Killer Cells, and Neutrophils Responding to Pulmonary Infection in BALB/c Mice

1999 ◽  
Vol 73 (9) ◽  
pp. 7099-7107 ◽  
Author(s):  
Ralph A. Tripp ◽  
Deborah Moore ◽  
Les Jones ◽  
Wayne Sullender ◽  
Jorn Winter ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
G Protein ◽  
Dna Vaccines ◽  
Pulmonary Eosinophilia ◽  
Killer Cells ◽  
Challenge Virus ◽  
Tumor Necrosis Factor Expression ◽  
Syncytial Virus

ABSTRACT BALB/c mice sensitized to vaccinia virus expressed G protein of respiratory syncytial virus (RSV) develop a Th2-type cytokine response and pulmonary eosinophilia when challenged with live RSV. In this study, BALB/c mice were immunized or challenged with an RSV mutant lacking the G and SH proteins or with DNA vaccines coding for RSV G or F protein. F or G protein DNA vaccines were capable of sensitizing for pulmonary eosinophilia. The absence of the G and/or SH protein in the infecting virus resulted in a consistent increase both in pulmonary natural killer cells and in gamma interferon and tumor necrosis factor expression, as well as, with primary infection, a variable increase in neutrophils and CD11b+ cells. The development of pulmonary eosinophilia in formalin-inactivated RSV-vaccinated mice required the presence of the G and/or SH protein in the challenge virus. These data show that G and/or SH protein has a marked impact on the inflammatory and innate immune response to RSV infection.

scholarly journals Vaccination of Macaques with Adjuvanted Formalin-Inactivated Influenza A Virus (H5N1) Vaccines: Protection against H5N1 Challenge without Disease Enhancement

2007 ◽  
Vol 82 (5) ◽  
pp. 2565-2569 ◽  
Author(s):  
Caroline Ruat ◽  
Catherine Caillet ◽  
Alexandre Bidaut ◽  
James Simon ◽  
Albert D. M. E. Osterhaus
Keyword(s):  
Influenza A Virus ◽  
Measles Virus ◽  
Influenza A ◽  
Upper Respiratory Tract ◽  
Disease Exacerbation ◽  
Water Emulsion ◽  
Virus H5n1 ◽  
Oil In Water ◽  
Syncytial Virus ◽  
Oil In Water Emulsion

ABSTRACT We investigated the ability of adjuvanted, inactivated split-virion influenza A virus (H5N1) vaccines to protect against infection and demonstrated that the disease exacerbation phenomenon seen with adjuvanted formaldehyde-inactivated respiratory syncytial virus and measles virus investigational vaccines did not occur with these H5N1 vaccines. Macaques were vaccinated twice with or without an aluminum hydroxide or oil-in-water emulsion adjuvanted vaccine. Three months later, animals were challenged with homologous wild-type H5N1. No signs of vaccine-induced disease exacerbation were seen. With either adjuvant, vaccination induced functional and cross-reactive antibodies and protected the lungs and upper respiratory tract. Without an adjuvant, the vaccine provided partial protection. Best results were obtained with the emulsion adjuvant.

Sign in / Sign up

Export Citation Format

Share Document