Electrophysiological Mapping and Monitoring during an Awake Craniotomy for Low-Grade Glioma: Case Report

2019 ◽  
Vol 59 (3) ◽  
pp. 133-141
Author(s):  
Justin W. Silverstein ◽  
Andrew Rosenthal ◽  
Nitesh V. Patel ◽  
John A. Boockvar
Keyword(s):  
Case Report ◽  
Low Grade Glioma ◽  
Awake Craniotomy ◽  
Low Grade ◽  
Glioma Case

Spontaneous intraventricular hemorrhage from low-grade optic glioma: case report and review of the literature

2011 ◽  
Vol 28 (2) ◽  
pp. 327-330 ◽  
Author(s):  
Jason D. Hill ◽  
Michael S. Rhee ◽  
John R. Edwards ◽  
Matthew C. Hagen ◽  
Daniel H. Fulkerson
Keyword(s):  
Case Report ◽  
Intraventricular Hemorrhage ◽  
Optic Glioma ◽  
Low Grade ◽  
Review Of The Literature ◽  
Glioma Case

scholarly journals Intraoperative electrical stimulation in awake craniotomy: methodological aspects of current practice

2010 ◽  
Vol 28 (2) ◽  
pp. E7 ◽  
Author(s):  
Andrea Szelényi ◽  
Lorenzo Bello ◽  
Hugues Duffau ◽  
Enrica Fava ◽  
Guenther C. Feigl ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Cognitive Function ◽  
Low Grade Glioma ◽  
Awake Craniotomy ◽  
Awake Surgery ◽  
Low Grade ◽  
Glioma Surgery ◽  
Neurological Sequelae ◽  
Intraoperative Electrical Stimulation ◽  
Methodological Aspects

There is increasing evidence that the extent of tumor removal in low-grade glioma surgery is related to patient survival time. Thus, the goal of resecting the largest amount of tumor possible without leading to permanent neurological sequelae is a challenge for the neurosurgeon. Electrical stimulation of the brain to detect cortical and axonal areas involved in motor, language, and cognitive function and located within the tumor or along its boundaries has become an essential tool in combination with awake craniotomy. Based on a literature review, discussions within the European Low-Grade Glioma Group, and illustrative clinical experience, the authors of this paper provide an overview for neurosurgeons, neurophysiologists, linguists, and anesthesiologists as well as those new to the field about the stimulation techniques currently being used for mapping sensorimotor, language, and cognitive function in awake surgery for low-grade glioma. The paper is intended to help the understanding of these techniques and facilitate a comparison of results between users.

scholarly journals Corpora amylacea mimicking low-grade glioma and manifesting as a seizure: Case report

2017 ◽  
Vol 8 (1) ◽  
pp. 64
Author(s):  
Isaac Yang ◽  
SeungJ Lee ◽  
Minsu Kim ◽  
Carlito Lagman ◽  
TimothyT Bui ◽  
...  
Keyword(s):  
Case Report ◽  
Low Grade Glioma ◽  
Low Grade ◽  
Corpora Amylacea

scholarly journals Improving multidisciplinary communication during awake craniotomy: First use of a novel robotic exoscope

2019 ◽  
Vol 21 (Supplement_4) ◽  
pp. iv17-iv18
Author(s):  
Anam Anzak ◽  
Alex Alamri ◽  
Thomas Doke ◽  
Grainne McKenna ◽  
Andrew Elsmore ◽  
...  
Keyword(s):  
Learning Curve ◽  
Inferior Frontal Gyrus ◽  
Structured Interview ◽  
Low Grade Glioma ◽  
Stereoscopic Vision ◽  
Awake Craniotomy ◽  
Low Grade ◽  
Data Generation ◽  
Multidisciplinary Communication ◽  
Team Members

Abstract Background Awake craniotomies require exceptional intra-operative communication between the multidisciplinary team. This is difficult with traditional operating microscopes, where the operative field cannot be visualised by all parties. The Synaptive Modus V is a hands-free, robotic, extracorporeal telescope (exoscope), allowing images to be viewed on multiple large monitors. The Royal London Hospital is the first United Kingdom installation of this device and the first unit in Europe to apply it to awake craniotomies for low-grade glioma. Methods Two consecutive patients with low grade glioma underwent awake craniotomy using the Modus V. Qualitative feedback (semi-structured interview) was received from the MDT including surgeons, occupational/ speech and language/ physio-therapists, neurophysiologists, anaesthetists and scrub team. Optimal device positioning is described. Results Both female patients (38 and 52 years old) underwent surgery between December 2018 and February 2019. Lesions were located in right perisylvian and posterior inferior frontal gyrus locations respectively. Surgical resection was satisfactory. Patient 1 developed a wrist-drop intra-operatively. Patient 2 had transient mild word finding difficulties. Surgeons reported easier surgical flow with hands-free positioning, larger working area and improved ergonomics. Adapting to non-stereoscopic vision increased operating times. Multi-disciplinary team members reported an better communication with the operating surgeon during patient assessment and a more involved educational experience. Conclusion Hands-free exoscopes may provide improved surgical flow and efficiency for awake craniotomy whilst simultaneously improving multidisciplinary communication and education. There is an, as yet, unidentified learning curve for its use that requires learning curve data generation.

Transient Hepatotoxicity Induced by Vinblastine in a Young Girl with Chiasmatic Low Grade Glioma

2020 ◽  
Vol 15 (3) ◽  
pp. 231-235
Author(s):  
Niels E. Franke ◽  
Geert J. Blok ◽  
Marsha L. Voll ◽  
Antoinette Y.N. S.-V. Meeteren
Keyword(s):  
Case Report ◽  
Main Side Effect ◽  
Fold Increase ◽  
Low Grade Glioma ◽  
Cytostatic Drug ◽  
Low Grade ◽  
Toxicity Screening ◽  
Standard Chemotherapy ◽  
Age Related ◽  
End Of Treatment

Background: Vinblastine (VBL) is a cytostatic drug frequently applied in children with lymphoma and progressive low-grade glioma (LGG), with hematotoxicity as the main side effect. Case Report: Here, the case of a 7-month-old girl with tumor progression of an LGG during standard chemotherapy with carboplatin and vincristine, is presented. Switching to VBL led to a 20-30- fold increase of transaminases (grade IV CTCAE 5.0), spontaneously resolving after the end of treatment. The toxicity is possibly age-related since it did not re-occur at the restart of VBL at 4 years old. This finding might have consequences for toxicity screening in future protocols, especially when including infants.

JS01.4.A The neurocognitive function changes with awake craniotomy for low-grade glioma in the left hemispheric eloquent regions

2021 ◽  
Vol 23 (Supplement_2) ◽  
pp. ii5-ii5
Author(s):  
Y Wang ◽  
P Ji ◽  
S Guo ◽  
J Liu ◽  
Y Zhai ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Brain Mapping ◽  
Treatment Strategy ◽  
Cognitive Assessment ◽  
Tumor Resection ◽  
Tumor Location ◽  
Low Grade Glioma ◽  
Awake Craniotomy ◽  
Low Grade ◽  
Eloquent Area

Abstract BACKGROUND Cognitive deficit was frequently observed in glioma patients, especially for those on the eloquent area. Considering the increased life expectancy, brain mapping during awake craniotomy was preferentially applied to exacerbate neurocognitive deficits. The aim of the current study was to evaluate the neurocognitive changes during the perioperative period of resection of low-grade glioma (LGG) in the left side eloquent area with awake craniotomy in a major neurosurgical center in China for 5 years. MATERIAL AND METHODS We retrospectively analyzed patients with left-sided glioma in eloquent areas, who received awake craniotomy during 2016–2020. Montreal Cognitive Assessment Scale, BN-20, and EORTC-QLQ-C30 questionnaire were applied for neurological cognitive assessment. We performed a correlation analysis between changes in cognitive performance and tumor characteristics, including tumor location, pathological grade. Treatment-related factors were also analyzed, such as the extent of resection (EOR), preoperative and postoperative Karnofsky Performance Score (KPS), postoperative treatment strategy (chemo- and radiotherapy), progression-free survival (PFS), overall survival (OS). RESULTS 68 patients were included in our current study. For the language domain, memory domain, and executive functions, 7.4% (5/68) patients presented mild postoperative cognitive performance deterioration compared to preoperative. Tumor location was the only factor that greatly influenced the postoperative cognitive performance, while other features (EOR, KPS, pathological grades) and treatment strategy were found no effect on cognitive change. The extent of tumor resection ranged from 81% to 100%. CONCLUSION Our study underlines the importance of the application of brain mapping during awake craniotomy, which helps to maximize extent of tumor resection while preserving cognitive function in individuals with LGG in eloquent regions.

Progression of Low-Grade Glioma During Pregnancy With Subsequent Regression Postpartum Without Treatment—A Case Report

Neurosurgery ◽  
2018 ◽  
Vol 84 (6) ◽  
pp. E430-E436 ◽  
Author(s):  
Amar S Shah ◽  
Lisa K Nicoletti ◽  
Elvisa Kurtovic ◽  
Christina I Tsien ◽  
Tammie L S Benzinger ◽  
...  
Keyword(s):  
Case Report ◽  
Low Grade Glioma ◽  
Low Grade

scholarly journals Awake Craniotomy for Left Insular Low-Grade Glioma Removal on a Patient with Learning Disabilities

2017 ◽  
Vol 06 (01) ◽  
pp. 041-043 ◽  
Author(s):  
Andrej Vranic ◽  
Blaz Koritnik ◽  
Jasmina Markovic-Bozic
Keyword(s):  
Learning Disabilities ◽  
Case Report ◽  
Brain Tumors ◽  
Awake Craniotomy ◽  
Awake Surgery ◽  
Cortical Mapping ◽  
Low Grade ◽  
Low Grade Gliomas ◽  
Eloquent Areas ◽  
Slow Growing

Introduction Low-grade gliomas (LGG) are slow-growing primary brain tumors in adults, with high tropism for eloquent areas. Standard approach in treatment of LGG is awake craniotomy with intraoperative cortical mapping — a method which is usually used on adult and fully cooperative patients. Case Report We present the case of a patient with learning disabilities (PLD) who was operated for left insular LGG awake craniotomy, and intraoperative cortical mapping were performed and the tumor was gross totally removed. Conclusion Awake surgery for left insular LGG removal is challenging; however, it can be performed safely and successfully on PLD.

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