Isoliquiritigenin attenuates acute renal injury through suppressing oxidative stress, fibrosis and JAK2/STAT3 pathway in streptozotocin-induced diabetic rats

Contrast-induced acute renal injury (CI-AKI) has become a common cause of hospital-acquired renal failure. However, the development of prophylaxis strategies and approved therapies for CI-AKI is limited. Salvianolic acid B (SB) can treat cardiovascular-related diseases. The aim of the present study was to assess the effect of SB on prevention of CI-AKI and explore its underlying mechanisms. We examined its effectiveness of preventing renal injury in a novel CI-AKI rat model. Compared with saline, intravenous SB pretreatment significantly attenuated elevations in serum creatinine and the histological changes of renal tubular injuries, reduced the number of apoptosis-positive tubular cells, activated Nrf2, and lowered the levels of renal oxidative stress induced by iodinated contrast media. The above renoprotection of SB was abolished by the PI3K inhibitor (wortmannin). In HK-2 cells, SB activated Nrf2 and decreased the levels of oxidative stress induced by hydrogen peroxide and subsequently improved cell viability. The above cytoprotection of SB was blocked by the PI3K inhibitor (wortmannin) or siNrf2. Thus, our results demonstrate that, due to its antioxidant properties, SB has the potential to effectively prevent CI-AKI via the PI3K/Akt/Nrf2 pathway.

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Phenethyl isothiocyanate alleviates renal injury in STZ‐induced diabetic rats: Effect on oxidative stress, glycative stress and inflammation

The FASEB Journal ◽

10.1096/fasebj.2021.35.s1.00390 ◽

2021 ◽

Vol 35 (S1) ◽

Author(s):

Mohamed El‐Sherbiny ◽

Nada Eisa ◽

Eman Said ◽

Nehal Elsherbiny

Keyword(s):

Oxidative Stress ◽

Renal Injury ◽

Diabetic Rats ◽

Phenethyl Isothiocyanate

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Kefir administration reduced progression of renal injury in STZ-diabetic rats by lowering oxidative stress

Nitric Oxide ◽

10.1016/j.niox.2013.12.012 ◽

2014 ◽

Vol 37 ◽

pp. 53-60 ◽

Cited By ~ 30

Author(s):

Giovana R. Punaro ◽

Fabiane R. Maciel ◽

Adelson M. Rodrigues ◽

Marcelo M. Rogero ◽

Cristina S.B. Bogsan ◽

...

Keyword(s):

Oxidative Stress ◽

Renal Injury ◽

Diabetic Rats

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Berberine ameliorates renal injury in streptozotocin-induced diabetic rats by suppression of both oxidative stress and aldose reductase

Chinese Medical Journal ◽

10.1097/00029330-200804020-00009 ◽

2008 ◽

Vol 121 (8) ◽

pp. 706-712 ◽

Cited By ~ 61

Author(s):

Wei-hua LIU ◽

Zi-qing HEI ◽

Hong NIE ◽

Fu-tian TANG ◽

He-qing HUANG ◽

...

Keyword(s):

Oxidative Stress ◽

Aldose Reductase ◽

Renal Injury ◽

Diabetic Rats

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Protective effects of naringin and trimetazidine on remote effect of acute renal injury on oxidative stress and myocardial injury through Nrf-2 regulation

Pharmacological Reports ◽

10.1016/j.pharep.2019.06.007 ◽

2019 ◽

Vol 71 (6) ◽

pp. 1059-1066 ◽

Cited By ~ 13

Author(s):

Negin Amini ◽

Alireza Sarkaki ◽

Mahin Dianat ◽

Seyyed Ali Mard ◽

Akram Ahangarpour ◽

...

Keyword(s):

Oxidative Stress ◽

Renal Injury ◽

Myocardial Injury ◽

Protective Effects ◽

Acute Renal Injury

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Amygdalin alleviates renal injury by suppressing inflammation, oxidative stress and fibrosis in streptozotocin-induced diabetic rats

Life Sciences ◽

10.1016/j.lfs.2020.118835 ◽

2021 ◽

Vol 265 ◽

pp. 118835

Author(s):

Jiawei Chen ◽

Yongbin Hu ◽

Xin Mou ◽

Huiyang Wang ◽

Zhujuan Xie

Keyword(s):

Oxidative Stress ◽

Renal Injury ◽

Diabetic Rats

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AP39, A Mitochondrially Targeted Hydrogen Sulfide Donor, Exerts Protective Effects in Renal Epithelial Cells Subjected to Oxidative Stress in Vitro and in Acute Renal Injury in Vivo

Shock ◽

10.1097/shk.0000000000000478 ◽

2016 ◽

Vol 45 (1) ◽

pp. 88-97 ◽

Cited By ~ 49

Author(s):

Akbar Ahmad ◽

Gabor Olah ◽

Bartosz Szczesny ◽

Mark E. Wood ◽

Matthew Whiteman ◽

...

Keyword(s):

Oxidative Stress ◽

Hydrogen Sulfide ◽

Epithelial Cells ◽

Renal Injury ◽

Protective Effects ◽

Acute Renal Injury ◽

Renal Epithelial Cells

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Protective Effect of Coptis chinensis Polysaccharide Against Renal Injury by Suppressing Oxidative Stress and Inflammation in Diabetic Rats

Natural Product Communications ◽

10.1177/1934578x19860998 ◽

2019 ◽

Vol 14 (9) ◽

pp. 1934578X1986099

Author(s):

Shuang Jiang ◽

Yong Tang ◽

Yang Bao ◽

Xin Su ◽

Kexin Li ◽

...

Keyword(s):

Oxidative Stress ◽

Protective Effect ◽

Renal Injury ◽

Renal Tissue ◽

Diabetic Rats ◽

The Body ◽

Antidiabetic Activity ◽

Coptis Chinensis ◽

Tyrosine Kinase 2 ◽

Underlying Mechanisms

Our previous studies confirmed that Coptis chinensis polysaccharide (CCPW) had a good antidiabetic activity and could improve insulin resistance. However, whether CCPW has a protective effect against the renal injury caused by diabetes has not been reported. In this study, the protective effect of CCPW against the renal injury of diabetic rats and its underlying mechanisms were investigated. The results showed that in CCPW-treated groups, the body mass of rats increased significantly, while the ratio of kidney weight to body weight decreased significantly; the 24-hour urine protein and the serum BUN and serum creatinine (Scr) levels decreased significantly, and pathological changes of the renal tissue were improved; superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities in the renal tissue were significantly higher, and malondialdehyde (MDA) contents in the renal tissue, and tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6), and hypersensitive c-reactive protein (hs-CRP) levels in the serum were significantly lower; the expressions of phosphorylated tyrosine kinase 2 (p-JAK2) and activators of transcription 3 (p-STAT3) decreased significantly. The results indicate that CCPW should have a protective effect against the renal injury in diabetic rats, which may be associated with its inhibition on oxidative stress and inflammation.

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