scholarly journals ETS Proto-Oncogene 1-activated muskelin 1 antisense RNA drives the malignant progression of hepatocellular carcinoma by targeting miR-22-3p to upregulate ETS Proto-Oncogene 1

Bioengineered ◽  
2022 ◽  
Vol 13 (1) ◽  
pp. 1346-1358
Author(s):  
Guozheng Pan ◽  
Jian Zhang ◽  
Faping You ◽  
Tao Cui ◽  
Peng Luo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Antisense Rna ◽  
Malignant Progression

scholarly journals E2F1-Induced lncRNA BAIAP2-AS1 Overexpression Contributes to the Malignant Progression of Hepatocellular Carcinoma via miR-361-3p/SOX4 Axis

2021 ◽  
Vol 2021 ◽  
pp. 1-18
Author(s):  
Yan Yang ◽  
Hong Ge ◽  
De-qing Li ◽  
Ai-xia Xu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Therapeutic Target ◽  
Antisense Rna ◽  
Noncoding Rnas ◽  
Malignant Progression ◽  
Long Noncoding Rnas ◽  
Positive Interaction ◽  
Potential Therapeutic Target ◽  
Proliferation And Metastasis ◽  
Hcc Cells

Currently, plenty of researches have revealed that long noncoding RNAs (lncRNAs) can act as crucial roles during the progression of various tumors, including hepatocellular carcinoma (HCC). Here, we measured the expression of lncRNA BAIAP2 antisense RNA 1(BAIAP2-AS1) as well as its contribution to the developments of HCC. In this study, the expressions of BAIAP2-AS1 and SOX4 were distinctly upregulated in HCC cells and tissues, and high BAIAP2-AS1 may be a novel biomarker for HCC. E2F1 activated BAIAP2-AS1 expression. The silence of BAIAP2-AS1 inhibited the proliferation and metastasis of HepG2 and PLC5 cells. Assays for relationship verification showed that BAIAP2-AS1 regulated the expression of SOX4 and miR-361-3p. Rescue experiments further confirmed the positive interaction between miR-361-3p and BAIAP2-AS1 as well as between miR-361-3p and SOX4. Overall, BAIAP2-AS1 modulated the miR-361-3p/SOX4 axis to promote the development of HCC. Thus, our study offers a potential therapeutic target for treating HCC.

The long noncoding RNA HOTAIR activates autophagy by upregulating ATG3 and ATG7 in hepatocellular carcinoma

2016 ◽  
Vol 12 (8) ◽  
pp. 2605-2612 ◽  
Author(s):  
Liang Yang ◽  
Xiuwei Zhang ◽  
Hangyu Li ◽  
Jingang Liu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Cell ◽  
Long Noncoding Rna ◽  
Antisense Rna ◽  
Noncoding Rna ◽  
Cell Development

The long noncoding RNA HOX transcript antisense RNA (HOTAIR) has been reported to be an oncogene that influences tumor cell development and that correlates with prognosis in hepatocellular carcinoma (HCC).

Autophagic LC3B overexpression correlates with malignant progression and predicts a poor prognosis in hepatocellular carcinoma

Tumor Biology ◽  
2014 ◽  
Vol 35 (12) ◽  
pp. 12225-12233 ◽  
Author(s):  
Dong-Hao Wu ◽  
Chang-Chang Jia ◽  
Jie Chen ◽  
Ze-Xiao Lin ◽  
Dan-Yun Ruan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Poor Prognosis ◽  
Malignant Progression

Genetic inactivation of theAPC gene contributes to the malignant progression of sporadic hepatocellular carcinoma: A case report

2006 ◽  
Vol 45 (11) ◽  
pp. 1050-1057 ◽  
Author(s):  
Hiroto Katoh ◽  
Tatsuhiro Shibata ◽  
Akiko Kokubu ◽  
Hidenori Ojima ◽  
Tomoo Kosuge ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Case Report ◽  
Malignant Progression ◽  
Genetic Inactivation

scholarly journals Resveratrol inhibits the malignant progression of hepatocellular carcinoma via MARCH1-induced regulation of PTEN/AKT signaling

Aging ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 11717-11731
Author(s):  
Hanhan Dai ◽  
Minjing Li ◽  
Wei Yang ◽  
Xiucui Sun ◽  
Peiyuan Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Akt Signaling ◽  
Malignant Progression

scholarly journals MiR-513b-5p represses autophagy during the malignant progression of hepatocellular carcinoma by targeting PIK3R3

Aging ◽  
2021 ◽  
Author(s):  
Wei Jin ◽  
Yilei Liang ◽  
Shuyou Li ◽  
Guoxiang Lin ◽  
Haiying Liang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Malignant Progression
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