scholarly journals A promising cancer diagnosis and treatment strategy: targeted cancer therapy and imaging based on antibody fragment

2019 ◽  
Vol 47 (1) ◽  
pp. 3621-3630 ◽  
Author(s):  
Xuhong Zhao ◽  
Qian Ning ◽  
Zhongcheng Mo ◽  
Shengsong Tang
Keyword(s):  
Cancer Therapy ◽  
Cancer Diagnosis ◽  
Treatment Strategy ◽  
Antibody Fragment ◽  
Diagnosis And Treatment ◽  
Targeted Cancer Therapy

scholarly journals Increasing Tumor Accessibility with Conjugatable Disulfide-Bridged Tumor-Penetrating Peptides for Cancer Diagnosis and Treatment

2015 ◽  
Vol 9s2 ◽  
pp. BCBCR.S29426 ◽  
Author(s):  
Venkata Ramana Kotamraju ◽  
Shweta Sharma ◽  
Poornima Kolhar ◽  
Lilach Agemy ◽  
James Pavlovich ◽  
...  
Keyword(s):  
Biological Activity ◽  
Cancer Therapy ◽  
Disulfide Bond ◽  
Cancer Diagnosis ◽  
Anticancer Agent ◽  
Diagnosis And Treatment ◽  
Targeted Cancer Therapy ◽  
N Terminus ◽  
Tumor Homing

Tumor-homing peptides with tissue-penetrating properties increase the efficacy of targeted cancer therapy by delivering an anticancer agent to the tumor interior. LyP-1 (CGNKRTRGC) and iRGD (CRGDKGPDC) are founding members of this class of peptides. The presence of the cysteines forming the cyclizing disulfide bond complicates conjugation of these peptides with other molecules, such as drugs. Here, we report the synthesis of conjugatable disulfide-bridged peptides and their conjugation to biologically important molecules. We have synthesized the LyP-1, iRGD, and CRGDC (GACRGDCLGA) peptides with a cysteine or maleimidohexanoic acid added externally at N-terminus of the sequences. Subsequent conjugation to payloads yielded stable compounds in which the tumor-homing properties of the peptide and the biological activity of the payload were retained.

scholarly journals ROLE OF CIRCULAR RNAS IN TUMORIGENESIS AND THEIR POSSIBLE APPLICATIONS IN CANCER DIAGNOSIS AND TREATMENT

2021 ◽  
Vol 9 (02) ◽  
pp. 571-577
Author(s):  
M. Samy Awad ◽  
◽  
Waleed Elagawy ◽  
H.A. Al-Sawaf ◽  
Heba Taha ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cancer Diagnosis ◽  
Biological Markers ◽  
Cellular Proliferation ◽  
Laboratory Diagnosis ◽  
Diagnosis And Treatment ◽  
Circular Rnas ◽  
Diagnosis Of Cancer ◽  
Knowledge Of Cancer

Circular RNAs (circRNAs) play critical roles in the development and progression of diseases, especially in cancer. Thus, expanding our understanding of circRNAs will enrich knowledge of cancer and give new opportunities for cancer therapy. In this review, we discuss the genesis of circular RNAs, their types and epigenetic aspects in tumorigenesis of abnormal cellular proliferation. The possible applications of individual circRNAs as biological markers in laboratory diagnosis of cancer received considerable attention recently.

A collagen-binding EGFR single-chain Fv antibody fragment for the targeted cancer therapy

2015 ◽  
Vol 209 ◽  
pp. 101-109 ◽  
Author(s):  
Hui Liang ◽  
Xiaoran Li ◽  
Bing Chen ◽  
Bin Wang ◽  
Yannan Zhao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Antibody Fragment ◽  
Targeted Cancer Therapy ◽  
Single Chain ◽  
Collagen Binding ◽  
Single Chain Fv ◽  
Fv Antibody ◽  
Single Chain Fv Antibody

Swallowing disorders in cervico-facial tumors – diagnosis and treatment strategy

ORL ro ◽  
2018 ◽  
Vol 2 (39) ◽  
pp. 18
Author(s):  
Daniela Vrînceanu ◽  
Mihai Dumitru ◽  
Bogdan Bănică ◽  
Adriana Nica
Keyword(s):  
Treatment Strategy ◽  
Swallowing Disorders ◽  
Diagnosis And Treatment

Targeted Cancer Therapy; Nanotechnology Approaches for Overcoming Drug Resistance

2015 ◽  
Vol 22 (11) ◽  
pp. 1335-1347 ◽  
Author(s):  
Yan Gao ◽  
Jacson Shen ◽  
Lara Milane ◽  
Francis Hornicek ◽  
Mansoor Amiji ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Cancer Therapy ◽  
Targeted Cancer Therapy

Biological Carrier Molecules of Radiopharmaceuticals for Molecular Cancer Imaging and Targeted Cancer Therapy

2014 ◽  
Vol 20 (32) ◽  
pp. 5218-5244 ◽  
Author(s):  
A. Aerts ◽  
N.R.E.N. Impens ◽  
M. Gijs ◽  
M. D'Huyvetter ◽  
H. Vanmarcke ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cancer Imaging ◽  
Targeted Cancer Therapy

TEM8 Targeted Cancer Therapy

2011 ◽  
Vol 11 (10) ◽  
pp. 983-992 ◽  
Author(s):  
Arthur E. Frankel ◽  
Carol Carter ◽  
Shu-Ru Kuo ◽  
Jung-Hee Woo ◽  
Jeremy Mauldin ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Cancer Therapy
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