scholarly journals Expression of Concern: Upregulation of long non-coding RNA OGFRP1 facilitates endometrial cancer by regulating miR-124-3p/SIRT1 axis and by activating PI3K/AKT/GSK-3b pathway

2020 ◽  
Vol 48 (1) ◽  
pp. 747-747
Keyword(s):  
Endometrial Cancer ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Long non-coding RNA TUG1 promotes endometrial cancer development via inhibiting miR-299 and miR-34a-5p

Oncotarget ◽  
2017 ◽  
Vol 8 (19) ◽  
pp. 31386-31394 ◽  
Author(s):  
Lifen Liu ◽  
Xin Chen ◽  
Ying Zhang ◽  
Yanrong Hu ◽  
Xiaoqing Shen ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Development ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals LncRNA TUG1 facilitates the development of endometrial cancer via interaction with FXR1

2021 ◽  
Vol 20 (9) ◽  
pp. 1839-1844
Author(s):  
Zhongjie Guo ◽  
Xuan Lin ◽  
Xiaoxia Guo
Keyword(s):  
Endometrial Cancer ◽  
Rna Binding ◽  
Fragile X ◽  
Metastatic Cancer ◽  
Cell Counting ◽  
Non Coding Rna ◽  
Ec Cells ◽  
Regulatory Effects ◽  
Long Non Coding Rna ◽  
Lncrna Tug1

Purpose: To investigate the potential influence of long non-coding RNA (lncRNA) TUG1 on the development of endometrial cancer (EC).Methods: A total of 24 paired EC species and paracancerous species were collected, and the differential expressions of TUG1 in them were determined. The regulatory effects of TUG1 on proliferative and migratory potential in Ishikawa and HEC-1A cells were assessed using cell counting kit-8 (CCK-8) and Transwell assay, respectively. Potential protein binding TUG1 was predicted by bioinformatics analysis and subsequently verified using RIP (RNA-Binding Protein Immunoprecipitation) assay. Rescue experiments were conducted to uncover the mechanism of TUG1 in regulating the development of EC.Results: TUG1 was highly expressed in EC species and cell lines. Higher levels of TUG1 was observed in EC patients with metastases than those without metastatic cancer (p < 0.05). Overexpression of TUG1 markedly facilitated proliferative and migratory potential in EC cells. Taurine-upregulated gene 1 (TUG1) directly bound Fragile X-related protein 1 (FXR1) and positively regulated its level (p < 0.05). Through interaction with FXR1, TUG1 stimulated the malignant development of EC.Conclusion: LncRNA TUG1 is upregulated in EC species, which facilitates proliferative and migratory potentials in EC cells by interacting with FXR1.

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