Zn(II) and Co(II)-based coordination polymers: anesthesia effect by regulating animal blood pressure in hip replacement operation

Introduction: Total Hip Replacement surgery is one of the most commonly performed surgeries worldwide. Epidural anaesthesia have shown decrease incidence of DVT in these patient. Hence, combined spinal epidural spinal anesthesia is now a preferred technique over spinal anesthesia alone. We have been practicing combined spinal epidural anesthesia routienely in total joint replacement, but have not analyzed the result. The aim of this study was to analyse various aspect of combined spinal epidura anesthesia. Methods: thirteen cases of ASA I and II who underwent Total Hip Arthroplasty under combined spinal epidural anesthesia were analysed. First epidural was given in space L2-3/L3-4 and patency was confirmed with test dose with InjXylocaine 2% with Adrenaline 3 ml, followed by Spinal anesthesia one space below with Bupivacaine 0.5% 3 ml. Results: Intra operative Mean Blood Pressure had dropped up to 55 mm of Hg.To maintain Blood pressure, Intravenous Fluid was given in average is 2423.077 ml and Vasopressure drug (Mephenteramine Maleate) was given in average of14.769 mg. Dura was accidentally puncture in one patient during epidural insertion and two epidural failed to provide post operative analgesia. Post operative rehabilitation was easy, one one patient developed DVT after 4 weeks of surgery. Conclusion: Combined epidural analgesia effectively manages postoperative pain, allows early ambulation and reduces the risk of deep vein thrombosis and thromboembolism, Although significant drop of Blood pressure was noted in all cases. DOI: http://dx.doi.org/10.3126/mjsbh.v10i1.6447 Medical Journal of Shree Birendra Hospital Jan-June 2011 10(1) 32-36

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Reversal of hemoglobin-induced vasoconstriction with sustained release of nitric oxide

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.00665.2010 ◽

2011 ◽

Vol 300 (1) ◽

pp. H49-H56 ◽

Cited By ~ 39

Author(s):

Pedro Cabrales ◽

George Han ◽

Parimala Nacharaju ◽

Adam J. Friedman ◽

Joel M. Friedman

Keyword(s):

Nitric Oxide ◽

Blood Pressure ◽

Vascular Complications ◽

Systemic Hypertension ◽

No Production ◽

Animal Blood ◽

Physiological Properties ◽

Chamber Model ◽

Plasma Nitrite ◽

Window Chamber

Erythrocyte free hemoglobin (Hb) induces vasoconstriction due to nitric oxide (NO) scavenging, limiting the NO available for vascular smooth muscle. The central objective of this study was to restore NO bioavailability using long-lived circulating NO-releasing nanoparticles (NO-np) to reverse the vasoconstriction and hypertension induced by polymerized bovine Hb (PBH) NO scavenging. PBH (13 g/dl) was infused in a volume equal to 10% of the animal blood volume. Intravascular NO supplementation was provided with an infusion of NO-np (10 and 20 mg/kg body wt). This study was performed using the hamster window chamber model to concurrently access systemic and microvascular hemodynamics. Infusion of PBH increased blood pressure and induced vasoconstriction. Treatment with 10 and 20 mg/kg NO-np reduced the blood pressure and vasoconstriction induced by PBH. Moreover, the higher dose of NO-np decreased blood pressure and induced vasodilation compared with baseline, respectively. Treatment with NO-np to decrease PBH-induced vasoconstriction increased methemoglobin levels and plasma nitrite and nitrate. In conclusion, NO-np counteracted both systemic hypertension and decreased the vasoconstrictor effects of PBH infusion, improving systemic and microvascular function. Based on the observed physiological properties, NO-np has clear potential as a therapeutic agent to replenish NO in situations where NO production is impaired, insufficient, or consumed, thereby preventing vascular complications.

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In Vivo Study of Carbon Artificial Femoral Head

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.434-435.613 ◽

2010 ◽

Vol 434-435 ◽

pp. 613-616

Author(s):

Lan Chen ◽

Xiao Bing Yuan ◽

Hong Wei Sun ◽

Ming Zhao Chen ◽

De Ben Zhao ◽

...

Keyword(s):

Femoral Head ◽

Hip Joint ◽

Hip Replacement ◽

Lower Cost ◽

Pyrolytic Carbon ◽

Hip Hemiarthroplasty ◽

X Ray ◽

Cartilage Wear ◽

Replacement Operation

Hip hemiarthroplasty is a popular method for curing hip joint diseases. Comparing with the total hip replacement (THR), hip hemiarthroplasty has some advantages, such as simpler operation, lower cost and less injury. However, inevitable acetabular cartilage wear, which leads to ultimately conversion to THR, has been reported by many authors. That limits its applications. To solve this problem, more suitable biomaterial should be chosen to make the femoral head. In this research, a kind of carbon femoral head, which was made of graphite coated with low temperature isotropic pyrolytic carbon, was studied in vivo. Nineteen New Zealand adult white rabbits were divided into 3 groups. Every rabbit was taken the replacement operation and time-dependently killed after certain periods. X-ray photographs of the hip joint, macroscopic apperarance and histological morphometry of the neocartilage around the prosthesis, were examined. The results proved that the coating material of the femoral head was biocompatible and the neocartilage tissue around the prothetic head might protect the acetabulum from wear. However, because of the complicated physiological environment, further research is needed.

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