Statistical Consideration of Adaptive Methods in Clinical Development

2005 ◽  
Vol 15 (4) ◽  
pp. 575-591 ◽  
Author(s):  
Shein-Chung Chow ◽  
Mark Chang ◽  
Annpey Pong
Keyword(s):  
Adaptive Methods ◽  
Clinical Development ◽  
Statistical Consideration

COVID-19 must catalyse changes to clinical development

2020 ◽  
Vol 19 (10) ◽  
pp. 653-654
Author(s):  
Rod MacKenzie ◽  
Peter Honig ◽  
Judy Sewards ◽  
Robert Goodwin ◽  
Marie-Pierre Hellio
Keyword(s):  
Clinical Development

Curcumin: New trends in the formulative and clinical development

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
P Morazzoni ◽  
A Riva ◽  
M Ronchi ◽  
G Petrangolini ◽  
W Cabri
Keyword(s):  
Clinical Development

Sending out Biased Signals: an Appropriate Proposition for Pain?

2019 ◽  
Vol 32 (2) ◽  
pp. 108-110 ◽  
Author(s):  
E. Besserer-Offroy ◽  
P. Sarret
Keyword(s):  
Side Effects ◽  
Acute Pain ◽  
Gold Standard ◽  
Pain Treatment ◽  
Opioid Analgesics ◽  
Mu Opioid Receptor ◽  
Clinical Development ◽  
Mu Opioid ◽  
Development Stages ◽  
The Past

In the past few years, several biased ligands acting at the mu-opioid receptor were reported in the literature. These agonists are aimed at reducing pain while having fewer side effects than morphine, the gold standard of opioid analgesics. In this mini-review, we describe and discuss the recent advances in mu-biased ligands actually in preclinical and clinical development stages, including the latest U.S. Food and Drug Administration review of oliceridine, a biased mu-agonist for moderate to severe acute pain treatment developed by the company Trevena.

THE PRACTICE OF APPLYING ADAPTIVE METHODS OF CAPITAL MANAGEMENT IN THE ENTERPRISES OF THE TOKTOGUL DISTRICT OF THE KYRGYZ REPUBLIC

2020 ◽  
Vol 1 (12) ◽  
pp. 79-82
Author(s):  
M. U. USUPOV ◽  
Keyword(s):  
Adaptive Methods ◽  
Kyrgyz Republic ◽  
Capital Management ◽  
Methods Of Analysis ◽  
Modern Methods ◽  
Economic Work ◽  
Effective Use

The article deals with the application of adaptive methods of capital management at enterprises of the Toktogul district of the Kyrgyz Republic. This area of economic work is considered a key point in the functioning of the firm. Questions of formation and effective use of own and borrowed capital largely depend on the use of modern methods of analysis.

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