INHIBITORY EFFECTS OF MAST CELL-MEDIATED ALLERGIC REACTIONS BY CELL CULTURED SIBERIAN GINSENG

2001 ◽  
Vol 23 (1) ◽  
pp. 107-117 ◽  
Author(s):  
H. J. Jeong ◽  
H. N. Koo ◽  
N. I. Myung ◽  
M. K. Shin ◽  
J. W. Kim ◽  
...  
Keyword(s):  
Mast Cell ◽  
Allergic Reactions ◽  
Inhibitory Effects ◽  
Siberian Ginseng

Inhibitory effects of atractylone on mast cell-mediated allergic reactions

2016 ◽  
Vol 258 ◽  
pp. 59-68 ◽  
Author(s):  
Na-Ra Han ◽  
Phil-Dong Moon ◽  
Sun-Young Nam ◽  
Ka-Jung Ryu ◽  
Myoung-Schook Yoou ◽  
...  
Keyword(s):  
Mast Cell ◽  
Allergic Reactions ◽  
Inhibitory Effects

The protective effect ofTinospora cordifoliaon various mast cell mediated allergic reactions

2009 ◽  
Vol 47 (11) ◽  
pp. 1096-1106 ◽  
Author(s):  
Rishit Zalawadia ◽  
Chintan Gandhi ◽  
Vaibhav Patel ◽  
Ramchandran Balaraman
Keyword(s):  
Mast Cell ◽  
Protective Effect ◽  
Allergic Reactions

Inhibitory effects of orientin in mast cell-mediated allergic inflammation

2020 ◽  
Vol 72 (4) ◽  
pp. 1002-1010
Author(s):  
Hima Dhakal ◽  
Soyoung Lee ◽  
Jin Kyeong Choi ◽  
Taeg Kyu Kwon ◽  
Dongwoo Khang ◽  
...  
Keyword(s):  
Mast Cell ◽  
Allergic Inflammation ◽  
Inhibitory Effects

Comparison of intestinal mast cell and basophil histamine release in children with food allergic reactions

Allergy ◽  
1989 ◽  
Vol 44 (8) ◽  
pp. 554-565 ◽  
Author(s):  
H. NOLTE ◽  
P. O. SCHIØTZ ◽  
A. KRUSE ◽  
P. STAHL SKOV
Keyword(s):  
Mast Cell ◽  
Histamine Release ◽  
Allergic Reactions

Cisatracurium induces mast cell activation and pseudo-allergic reactions via MRGPRX2

2018 ◽  
Vol 62 ◽  
pp. 244-250 ◽  
Author(s):  
Delu Che ◽  
Liu Rui ◽  
Jiao Cao ◽  
Jue Wang ◽  
Yongjing Zhang ◽  
...  
Keyword(s):  
Mast Cell ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Allergic Reactions

scholarly journals Preventative and Therapeutic Effects of Low-dose Ionizing Radiation on the Allergic Response of Rat Basophilic Leukemia Cells

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Hae Mi Joo ◽  
Eun Hee Hong ◽  
Seong-Jun Cho ◽  
Seon Young Nam ◽  
Ji Young Kim
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Ionizing Radiation ◽  
Therapeutic Effect ◽  
Cell Activation ◽  
Low Dose ◽  
Mast Cell Activation ◽  
Allergic Reactions ◽  
Antigen Antibody ◽  
Basophilic Leukemia

Abstract The prevalence of allergies has increased over the last four decades. In allergic reactions, mast cells induce a hypersensitive immune response to a substance that is normally harmless. Ionizing radiation has different biological effects depending on the dose and dose rate. In this study, we investigated whether low-dose irradiation before (preventative effect) or after (therapeutic effect) an antigen-antibody reaction has an anti-allergic effect. To test this, we activated rat basophilic leukemia (RBL-2H3) mast cells with anti-2,4-dinitrophenyl IgE (antibody) and 2,4-dinitrophenyl human serum albumin, which served as an antigen. To test for both the potential of a preventative effect and a therapeutic effect, we irradiated mast cells both before and after mast cell activation, and we measured mediator release and signaling pathway activity. Low-dose ionizing radiation suppressed mediator release from RBL-2H3 mast cells activated by the antigen-antibody reaction regardless of when the mast cells were irradiated. These results were due to the suppression of FcεRI expression. Therefore, we suggest that low-dose ionizing radiation has a preventative and therapeutic effect in allergic reactions via the FcεRI-mediated RBL-2H3 mast cell activation system.

scholarly journals Ethanol Extract of Sesamum indicum Linn. Inhibits FcεRI-Mediated Allergic Reaction via Regulation of Lyn/Syk and Fyn Signaling Pathways in Rat Basophilic Leukemic RBL-2H3 Mast Cells

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Hyun Ju Do ◽  
Tae Woo Oh ◽  
Kwang-Il Park
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Signaling Pathways ◽  
Inflammatory Mediators ◽  
Cell Activation ◽  
Immunoglobulin E ◽  
Sesamum Indicum ◽  
Mast Cell Activation ◽  
Allergic Reactions ◽  
Potent Effect

This study is aimed at determining whether Sesamum indicum Linn. beneficially influences FcεRI-mediated allergic reactions in RBL-2H3 mast cells; it is also aimed at further investigating Lyn/Fyn and Syk signaling pathways. To examine the antiallergic effect of Sesamum indicum Linn. extract (SIE), we treated antigen/immunoglobulin E- (IgE-) sensitized mast cells with extracts of various concentrations. We examined the degranulation release and concentrations of inflammatory mediators. Additionally, the expressions of genes involved in the FcεRI and arachidonate signaling pathways were examined. SIE inhibited the degranulation and secretion of inflammatory mediators in antigen/IgE-sensitized mast cells. SIE reduced the expressions of FcεRI signaling-related genes, such as Syk, Lyn, and Fyn, and the phosphorylation of extracellular signal-regulated kinase in antigen/IgE-sensitized mast cells. Additionally, in late allergic responses, SIE reduced PGD2 release and COX-2 and cPLA2 phosphorylation expression in FcεRI-mediated mast cell activation. Lastly, 250–500 mg/kg SIE significantly attenuated the Ag/IgE-induced passive cutaneous anaphylaxis (PCA) reaction in mice. The potent effect of SIE on RBL-2H3 mast cell activation indicates that the extract could potentially be used as a novel inhibitor against allergic reactions.

INHIBITORY EFFECT OF MAST CELL-MEDIATED IMMEDIATE-TYPE ALLERGIC REACTIONS BY CICHORIUM INTYBUS

1999 ◽  
Vol 40 (1) ◽  
pp. 61-65 ◽  
Author(s):  
HYUNG MIN KIM ◽  
HYE WON KIM ◽  
YEOUNG SU LYU ◽  
JIN HEE WON ◽  
DAE KI KIM ◽  
...  
Keyword(s):  
Mast Cell ◽  
Inhibitory Effect ◽  
Cichorium Intybus ◽  
Allergic Reactions
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