ON-LINE MONITORING AND COMPOSITION CONTROL OF THE EMULSION COPOLYMERIZATION OF VeoVA 9 AND BUTYL ACRYLATE BY RAMAN SPECTROSCOPY

2001 ◽  
Vol 9 (2) ◽  
pp. 101-133 ◽  
Author(s):  
Mark van den Brink ◽  
Michel Pepers ◽  
Alex M. van Herk ◽  
Anton L. German
Keyword(s):  
Raman Spectroscopy ◽  
Butyl Acrylate ◽  
Emulsion Copolymerization ◽  
Composition Control ◽  
On Line

Monitoring of High Solids Content Starved-Semi-Batch Emulsion Copolymerization Reactions by Fourier Transform Raman Spectroscopy

2005 ◽  
Vol 59 (10) ◽  
pp. 1270-1279 ◽  
Author(s):  
Oihana Elizalde ◽  
José M. Asua ◽  
Jose R. Leiza
Keyword(s):  
Raman Spectroscopy ◽  
Fourier Transform ◽  
Butyl Acrylate ◽  
High Solids ◽  
Emulsion Copolymerization ◽  
Ft Raman Spectroscopy ◽  
On Line ◽  
Solids Content ◽  
High Solids Content ◽  
Ft Raman

A high solids content n-butyl acrylate/methyl methacrylate emulsion copolymerization process carried out under starved semi-batch conditions was for the first time monitored on-line by means of Fourier transform (FT)-Raman spectroscopy. Partial least squares regression was employed to build calibration models that allowed relating the spectra with solids content (overall conversion), free amounts of both n-butyl acrylate (n-BA) and methyl methacrylate (MMA), and cumulative copolymer composition. In spite of the heterogeneous nature of the polymerization, the similarities of the spectra for MMA, n-BA, and for the copolymer, and the low monomer concentrations in the reactor, the FT-Raman spectroscopy has been shown to be a suitable noninvasive sensor to accurately monitor the process. Therefore, it is well suited for on-line control of all-acrylic polymerization systems.

APPLICATIONS OF COMPOSITION CONTROL TO THE STYRENE-BUTYL ACRYLATE EMULSION COPOLYMERIZATION

1998 ◽  
Vol 163 (1) ◽  
pp. 69-95 ◽  
Author(s):  
FRANCESCA GALIMBERTI ◽  
ANDRÉ SIANI ◽  
MASSIMO MORBIDELLI ◽  
GIUSEPPE STORTI†
Keyword(s):  
Butyl Acrylate ◽  
Emulsion Copolymerization ◽  
Composition Control ◽  
Acrylate Emulsion

Measurement of partial conversions during the solution copolymerization of styrene and butyl acrylate using on-line raman spectroscopy

2000 ◽  
Vol 79 (3) ◽  
pp. 426-436 ◽  
Author(s):  
Mark Van ◽  
Den Brink ◽  
Jacques-Fran�ois Hansen ◽  
Peter De Peinder ◽  
Alex M. Van Herk ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Butyl Acrylate ◽  
On Line

Emulsion (co) polymerization of styrene and butyl acrylate monitored by on-line Raman spectroscopy

2000 ◽  
Vol 150 (1) ◽  
pp. 121-126 ◽  
Author(s):  
Mark van den Brink ◽  
Michel Pepers ◽  
Alex M. van Herk ◽  
Anton L. German
Keyword(s):  
Raman Spectroscopy ◽  
Butyl Acrylate ◽  
On Line

Comparing near infrared and Raman spectroscopy for on-line monitoring of emulsion copolymerization reactions

2004 ◽  
Vol 206 (1) ◽  
pp. 165-178 ◽  
Author(s):  
Marlon M. Reis ◽  
Pedro H.H. Araújo ◽  
Claudia Sayer ◽  
Reinaldo Giudici
Keyword(s):  
Raman Spectroscopy ◽  
Near Infrared ◽  
Emulsion Copolymerization ◽  
Infrared And Raman Spectroscopy ◽  
On Line

On-Line Monitoring of Airborne Chemistry in Levitated Nanodroplets:  In Situ Synthesis and Application of SERS-Active Ag−Sols for Trace Analysis by FT-Raman Spectroscopy

2003 ◽  
Vol 75 (9) ◽  
pp. 2166-2171 ◽  
Author(s):  
Nicolae Leopold ◽  
Michael Haberkorn ◽  
Thomas Laurell ◽  
Johan Nilsson ◽  
Josefa R. Baena ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Trace Analysis ◽  
In Situ Synthesis ◽  
Ft Raman Spectroscopy ◽  
On Line ◽  
Ft Raman

scholarly journals Combining Mechanistic Modeling and Raman Spectroscopy for Monitoring Antibody Chromatographic Purification

Processes ◽  
2019 ◽  
Vol 7 (10) ◽  
pp. 683 ◽  
Author(s):  
Feidl ◽  
Garbellini ◽  
Luna ◽  
Vogg ◽  
Souquet ◽  
...  
Keyword(s):  
Experimental Data ◽  
Raman Spectroscopy ◽  
Estimation Procedure ◽  
Mechanistic Modeling ◽  
Spectroscopic Techniques ◽  
Chromatographic Purification ◽  
On Line ◽  
Filter Approach ◽  
Underlying Mechanisms ◽  
Combining Information

Chromatography is widely used in biotherapeutics manufacturing, and the corresponding underlying mechanisms are well understood. To enable process control and automation, spectroscopic techniques are very convenient as on-line sensors, but their application is often limited by their sensitivity. In this work, we investigate the implementation of Raman spectroscopy to monitor monoclonal antibody (mAb) breakthrough (BT) curves in chromatographic operations with a low titer harvest. A state estimation procedure is developed by combining information coming from a lumped kinetic model (LKM) and a Raman analyzer in the frame of an extended Kalman filter approach (EKF). A comparison with suitable experimental data shows that this approach allows for the obtainment of reliable estimates of antibody concentrations with reduced noise and increased robustness.

Microemulsion copolymerization of styrene-methyl methacrylate followed on line by low-resolution Raman spectroscopy

2009 ◽  
Vol 49 (11) ◽  
pp. 2125-2131 ◽  
Author(s):  
Miguel A. Corona-Rivera ◽  
Jorge Flores ◽  
Jorge E. Puig ◽  
Eduardo Mendizábal
Keyword(s):  
Raman Spectroscopy ◽  
Methyl Methacrylate ◽  
Low Resolution ◽  
On Line
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