Phage Display of Random Peptide Libraries: Applications, Limits, and Potential

2003 ◽  
Vol 23 (4) ◽  
pp. 307-349 ◽  
Author(s):  
Michael Szardenings
Keyword(s):  
Phage Display ◽  
Peptide Libraries ◽  
Random Peptide ◽  
Random Peptide Libraries

scholarly journals SAROTUP: Scanner and Reporter of Target-Unrelated Peptides

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Jian Huang ◽  
Beibei Ru ◽  
Shiyong Li ◽  
Hao Lin ◽  
Feng-Biao Guo
Keyword(s):  
Phage Display ◽  
Epitope Mapping ◽  
Surface Display ◽  
Epitope Prediction ◽  
Peptide Libraries ◽  
Screening System ◽  
Web Tool ◽  
Random Peptide ◽  
Random Peptide Libraries ◽  
Convenient Approach

As epitope mimics, mimotopes have been widely utilized in the study of epitope prediction and the development of new diagnostics, therapeutics, and vaccines. Screening the random peptide libraries constructed with phage display or any other surface display technologies provides an efficient and convenient approach to acquire mimotopes. However, target-unrelated peptides creep into mimotopes from time to time through binding to contaminants or other components of the screening system. In this study, we present SAROTUP, a free web tool for scanning, reporting and excluding possible target-unrelated peptides from real mimotopes. Preliminary tests show that SAROTUP is efficient and capable of improving the accuracy of mimotope-based epitope mapping. It is also helpful for the development of mimotope-based diagnostics, therapeutics, and vaccines.

scholarly journals Identification and characterization of Src SH3 ligands from phage-displayed random peptide libraries.

1994 ◽  
Vol 269 (39) ◽  
pp. 23853-23856
Author(s):  
A.B. Sparks ◽  
L.A. Quilliam ◽  
J.M. Thorn ◽  
C.J. Der ◽  
B.K. Kay
Keyword(s):  
Peptide Libraries ◽  
Random Peptide ◽  
Random Peptide Libraries ◽  
Identification And Characterization

Rapid and efficient identification of epitopes/mimotopes from random peptide libraries

2006 ◽  
Vol 316 (1-2) ◽  
pp. 67-74 ◽  
Author(s):  
Xiaoli Yu ◽  
Gregory P. Owens ◽  
Donald H. Gilden
Keyword(s):  
Peptide Libraries ◽  
Random Peptide ◽  
Random Peptide Libraries

Random Peptide Libraries as Tools in Basic and Applied Immunology

2007 ◽  
pp. 349-362 ◽  
Author(s):  
Keiko Udaka ◽  
Karl-Heinz Wiesmller ◽  
Stefan Kienle ◽  
Susanne Feiertag ◽  
Gunther Jung ◽  
...  
Keyword(s):  
Peptide Libraries ◽  
Random Peptide ◽  
Random Peptide Libraries
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