Abstract 1769: Phage display selection of cancer cell-binding and -internalizing ligands using random peptide libraries constructed at N-terminus of P99 cephalosporinase

2011 ◽  
Author(s):  
Girja S. Shukla ◽  
David N. Krag
Keyword(s):  
Phage Display ◽  
Cancer Cell ◽  
Peptide Libraries ◽  
Cell Binding ◽  
Random Peptide ◽  
Random Peptide Libraries ◽  
N Terminus ◽  
Selection Of

scholarly journals Novel random peptide libraries displayed on AAV serotype 9 for selection of endothelial cell-directed gene transfer vectors

Gene Therapy ◽  
2011 ◽  
Vol 19 (8) ◽  
pp. 800-809 ◽  
Author(s):  
K Varadi ◽  
S Michelfelder ◽  
T Korff ◽  
M Hecker ◽  
M Trepel ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Gene Transfer ◽  
Peptide Libraries ◽  
Random Peptide ◽  
Random Peptide Libraries ◽  
Transfer Vectors ◽  
Selection Of

scholarly journals SAROTUP: Scanner and Reporter of Target-Unrelated Peptides

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Jian Huang ◽  
Beibei Ru ◽  
Shiyong Li ◽  
Hao Lin ◽  
Feng-Biao Guo
Keyword(s):  
Phage Display ◽  
Epitope Mapping ◽  
Surface Display ◽  
Epitope Prediction ◽  
Peptide Libraries ◽  
Screening System ◽  
Web Tool ◽  
Random Peptide ◽  
Random Peptide Libraries ◽  
Convenient Approach

As epitope mimics, mimotopes have been widely utilized in the study of epitope prediction and the development of new diagnostics, therapeutics, and vaccines. Screening the random peptide libraries constructed with phage display or any other surface display technologies provides an efficient and convenient approach to acquire mimotopes. However, target-unrelated peptides creep into mimotopes from time to time through binding to contaminants or other components of the screening system. In this study, we present SAROTUP, a free web tool for scanning, reporting and excluding possible target-unrelated peptides from real mimotopes. Preliminary tests show that SAROTUP is efficient and capable of improving the accuracy of mimotope-based epitope mapping. It is also helpful for the development of mimotope-based diagnostics, therapeutics, and vaccines.

scholarly journals Identification and characterization of Src SH3 ligands from phage-displayed random peptide libraries.

1994 ◽  
Vol 269 (39) ◽  
pp. 23853-23856
Author(s):  
A.B. Sparks ◽  
L.A. Quilliam ◽  
J.M. Thorn ◽  
C.J. Der ◽  
B.K. Kay
Keyword(s):  
Peptide Libraries ◽  
Random Peptide ◽  
Random Peptide Libraries ◽  
Identification And Characterization
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