scholarly journals FOXO1a acts as a selective tumor suppressor in alveolar rhabdomyosarcoma

2005 ◽  
Vol 170 (6) ◽  
pp. 903-912 ◽  
Author(s):  
Philippe R.J. Bois ◽  
Kamel Izeradjene ◽  
Peter J. Houghton ◽  
John L. Cleveland ◽  
Janet A. Houghton ◽  
...  

Rhabdomyosarcoma (RMS), the most common pediatric soft-tissue sarcoma, has two major histological subtypes: embryonal RMS (ERMS), which has a favorable prognosis, and alveolar RMS (ARMS), which has a poor outcome. Although both forms of RMS express muscle cell–specific markers, only ARMS cells express PAX3-FOXO1a or PAX7-FOXO1a chimeric proteins. In mice, Pax3 and Pax7 play key roles in muscle cell development and differentiation, and FoxO1a regulates myoblast differentiation and fusion; thus, the aberrant regulation of these proteins may contribute to the development of ARMS. In this paper, we report that FOXO1a is not expressed in primary ARMS tumors or ARMS-derived tumor cell lines and that restoration of FOXO1a expression in ARMS cells is sufficient to induce cell cycle arrest and apoptosis. Strikingly, the effects of FOXO1a are selective, as enforced expression of FOXO1a in ERMS-derived tumor cell lines had no effect. Furthermore, FOXO1a induced apoptosis in ARMS by directly activating the transcription of caspase-3. We conclude that FOXO1a is a potent and specific tumor suppressor in ARMS, suggesting that agents that restore or augment FOXO1a activity may be effective as ARMS therapeutics.

2001 ◽  
Author(s):  
Mohammad Islam ◽  
Norio Mitsuhashi ◽  
Tetsuo Akimoto ◽  
Hideyuki Sakurai ◽  
Masatoshi Hasegawa ◽  
...  

1998 ◽  
Vol 60 (8) ◽  
pp. 923-929 ◽  
Author(s):  
Michihiro TAKAGI ◽  
Kazuhiko OHASHI ◽  
Toshifumi MORIMURA ◽  
Chihiro SUGIMOTO ◽  
Misao ONUMA

2021 ◽  
Author(s):  
Goran Kaluđerović ◽  

Free Ph3Sn(CH2)nOH (n = 3, 4, 6, 8 and 11) and immobilized organotin(IV) compounds, SBA- 15~Cl|Ph3Sn(CH2)nOH, were prepared and tested against different tumor cell lines. Both compounds and nanomaterials revealed strong cytotoxic potential. SBA-15~Cl|Ph3Sn(CH2)3OH as well as free compound induce caspase triggered apoptosis in human ovarian A2780 cells. Ph3Sn(CH2)6OH and corresponding nanomaterial induced apoptosis in mouse melanoma B16 cells. Survived clones of B16 cells demonstrated phenotypic changes, they differentiate toward melanocytes.


Sign in / Sign up

Export Citation Format

Share Document