MESOPOROUS SILICA AS A VEHICLE FOR ORGANOTIN(IV) COMPOUNDS

2021 ◽  
Author(s):  
Goran Kaluđerović ◽  
Keyword(s):  
Mesoporous Silica ◽  
Tumor Cell ◽  
Cell Lines ◽  
Tumor Cell Lines ◽  
Cytotoxic Potential ◽  
Phenotypic Changes ◽  
Mouse Melanoma ◽  
Melanoma B16 ◽  
Induced Apoptosis

Free Ph3Sn(CH2)nOH (n = 3, 4, 6, 8 and 11) and immobilized organotin(IV) compounds, SBA- 15~Cl|Ph3Sn(CH2)nOH, were prepared and tested against different tumor cell lines. Both compounds and nanomaterials revealed strong cytotoxic potential. SBA-15~Cl|Ph3Sn(CH2)3OH as well as free compound induce caspase triggered apoptosis in human ovarian A2780 cells. Ph3Sn(CH2)6OH and corresponding nanomaterial induced apoptosis in mouse melanoma B16 cells. Survived clones of B16 cells demonstrated phenotypic changes, they differentiate toward melanocytes.

Hyperthermia-induced apoptosis in two rat yolk sac tumor cell lines with different radiothermosensitivity in vitro

2001 ◽  
Author(s):  
Mohammad Islam ◽  
Norio Mitsuhashi ◽  
Tetsuo Akimoto ◽  
Hideyuki Sakurai ◽  
Masatoshi Hasegawa ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Yolk Sac ◽  
Yolk Sac Tumor ◽  
Tumor Cell Lines ◽  
Induced Apoptosis

scholarly journals FOXO1a acts as a selective tumor suppressor in alveolar rhabdomyosarcoma

2005 ◽  
Vol 170 (6) ◽  
pp. 903-912 ◽  
Author(s):  
Philippe R.J. Bois ◽  
Kamel Izeradjene ◽  
Peter J. Houghton ◽  
John L. Cleveland ◽  
Janet A. Houghton ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Cell ◽  
Cell Lines ◽  
Muscle Cell ◽  
Myoblast Differentiation ◽  
Tumor Cell Lines ◽  
Induce Cell Cycle Arrest ◽  
Specific Tumor ◽  
Development And Differentiation ◽  
Induced Apoptosis

Rhabdomyosarcoma (RMS), the most common pediatric soft-tissue sarcoma, has two major histological subtypes: embryonal RMS (ERMS), which has a favorable prognosis, and alveolar RMS (ARMS), which has a poor outcome. Although both forms of RMS express muscle cell–specific markers, only ARMS cells express PAX3-FOXO1a or PAX7-FOXO1a chimeric proteins. In mice, Pax3 and Pax7 play key roles in muscle cell development and differentiation, and FoxO1a regulates myoblast differentiation and fusion; thus, the aberrant regulation of these proteins may contribute to the development of ARMS. In this paper, we report that FOXO1a is not expressed in primary ARMS tumors or ARMS-derived tumor cell lines and that restoration of FOXO1a expression in ARMS cells is sufficient to induce cell cycle arrest and apoptosis. Strikingly, the effects of FOXO1a are selective, as enforced expression of FOXO1a in ERMS-derived tumor cell lines had no effect. Furthermore, FOXO1a induced apoptosis in ARMS by directly activating the transcription of caspase-3. We conclude that FOXO1a is a potent and specific tumor suppressor in ARMS, suggesting that agents that restore or augment FOXO1a activity may be effective as ARMS therapeutics.

Cytotoxic potential of essential oils of Eucalyptus benthamii and its related terpenes on tumor cell lines

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
PV Farago ◽  
PM Döll-Boscardin ◽  
CC Kanunfre ◽  
JM Budel
Keyword(s):  
Tumor Cell ◽  
Essential Oils ◽  
Cell Lines ◽  
Tumor Cell Lines ◽  
Cytotoxic Potential

Phenotypic changes on central nervous system (CNS) tumor cell lines cultured in vitro 2D and 3D models and treated with cisplatin

2021 ◽  
Vol 123 (6) ◽  
pp. 151768
Author(s):  
Bryan Ôrtero Perez Gonçalves ◽  
Gabryella Soares Pinheiro dos Santos ◽  
Warne Pedro de Andrade ◽  
Sílvia Ligório Fialho ◽  
Dawidson Assis Gomes ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Tumor Cell ◽  
Cell Lines ◽  
3D Models ◽  
Tumor Cell Lines ◽  
Cns Tumor ◽  
Phenotypic Changes ◽  
2D And 3D
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