A new life for an old pump: V-ATPase and neurotransmitter release
Keyword(s):
Neurons fire by releasing neurotransmitters via fusion of synaptic vesicles with the plasma membrane. Fusion can be evoked by an incoming signal from a preceding neuron or can occur spontaneously. Synaptic vesicle fusion requires the formation of trans complexes between SNAREs as well as Ca2+ ions. Wang et al. (2014. J. Cell Biol. http://dx.doi.org/jcb.201312109) now find that the Ca2+-binding protein Calmodulin promotes spontaneous release and SNARE complex formation via its interaction with the V0 sector of the V-ATPase.
2008 ◽
Vol 183
(2)
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pp. 323-337
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2021 ◽
Keyword(s):
2012 ◽
Vol 50
(9)
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pp. 1157-1167
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Keyword(s):
2020 ◽
2021 ◽
Vol 118
(34)
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pp. e2021742118