scholarly journals Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration

2018 ◽  
Vol 217 (10) ◽  
pp. 3327-3329 ◽  
Author(s):  
Laura E. Newman ◽  
Gerald S. Shadel
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mitochondrial Dna ◽  
Neurodegenerative Diseases ◽  
Mitochondrial Stress ◽  
Mitochondrial Dna Mutations ◽  
Dna Mutations ◽  
Age Related ◽  
Sting Pathway

What causes inflammation in age-related neurodegenerative diseases remains a mystery. Sliter et al. (2018. Nature. https://doi.org/10.1038/s41586-018-0448-9) show that, when damaged mitochondria cannot be removed by mitophagy, stress from exercise or mitochondrial DNA mutations activates the proinflammatory cGAS–STING pathway that may contribute to Parkinson’s disease.

Novel mitochondrial DNA mutations in Parkinson's disease

2002 ◽  
Vol 109 (5-6) ◽  
pp. 721-729 ◽  
Author(s):  
G. Richter ◽  
A. Sonnenschein ◽  
T. Grünewald ◽  
H. Reichmann ◽  
B. Janetzky
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mitochondrial Dna ◽  
Mitochondrial Dna Mutations ◽  
Dna Mutations

scholarly journals Mitochondrial DNA mutations in Parkinson's disease brain

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
David K. Simon ◽  
Joanne Clark Matott ◽  
Janaina Espinosa ◽  
Neeta A. Abraham
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mitochondrial Dna ◽  
Mitochondrial Dna Mutations ◽  
Dna Mutations

Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson’s disease

2004 ◽  
Vol 25 (1) ◽  
pp. 71-81 ◽  
Author(s):  
David K Simon ◽  
Michael T Lin ◽  
Leiya Zheng ◽  
Guang-Jun Liu ◽  
Colette H Ahn ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mitochondrial Dna ◽  
Substantia Nigra ◽  
Mitochondrial Dna Mutations ◽  
Dna Mutations

Mitochondrial DNA mutations in complex I and tRNA genes in Parkinson's disease

Neurology ◽  
2000 ◽  
Vol 54 (3) ◽  
pp. 703-703 ◽  
Author(s):  
D. K. Simon ◽  
R. Mayeux ◽  
K. Marder ◽  
N. W. Kowall ◽  
M. F. Beal ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mitochondrial Dna ◽  
Complex I ◽  
Trna Genes ◽  
Mitochondrial Dna Mutations ◽  
Dna Mutations

scholarly journals Mitochondrial Mutations

2011 ◽  
Vol 17 (6) ◽  
pp. 645-658 ◽  
Author(s):  
Nichola Z. Lax ◽  
Doug M. Turnbull ◽  
Amy K. Reeve
Keyword(s):  
Mitochondrial Dna ◽  
Neurodegenerative Diseases ◽  
Neurodegenerative Disease ◽  
Targeted Therapies ◽  
Neurological Diseases ◽  
Cell Loss ◽  
Mitochondrial Metabolism ◽  
Mitochondrial Mutations ◽  
Mitochondrial Dna Mutations ◽  
Dna Mutations

Mutations in mitochondrial DNA cause a number of neurological diseases with defined neuropathology; however, mutations in this genome have also been found to be important in a number of more common neurodegenerative diseases. In this review, the authors discuss the importance of mitochondrial DNA mutations in a number of different diseases and speculate how such mutations could lead to cell loss. Increasing our understanding of how mitochondrial DNA mutations affect mitochondrial metabolism and subsequently result in neurodegenerative disease will prove vital to the development of targeted therapies and treatments.

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