Cell-cycle analysis of insulin binding and internalization on mouse melanoma cells.
1981 ◽
Vol 88
(1)
◽
pp. 241-244
◽
Keyword(s):
S Phase
◽
Binding of 125I-labeled insulin to the surface receptors of Cloudman S-91 mouse melanoma cells (CCL 53.1) was studied at various phases (M, G1, S, and G2) in the cell cycle. Insulin-binding activity was persistently present during the cell cycle but the highest activity was noted at the S-phase. The insulin once bound to the cell surface receptors at any phase of the cell cycle was internalized and degraded, presumably through a lysosomal pathway. Insulin-indexing activity of melanoma cells was not affected by melanocyte-stimulating hormone.
1976 ◽
Vol 73
(2)
◽
pp. 559-562
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Keyword(s):
1974 ◽
Vol 71
(5)
◽
pp. 1590-1593
◽
Keyword(s):
1995 ◽
Vol 105
(5)
◽
pp. 655-659
◽
Keyword(s):
2007 ◽
pp. 79-90
◽
Keyword(s):
2018 ◽
Vol 70
(1)
◽
pp. 6-13
◽
1992 ◽
Vol 117
(6)
◽
pp. 1331-1341
◽
Keyword(s):
Keyword(s):
1990 ◽
Vol 132
(1)
◽
pp. 13-24
◽
Keyword(s):
Keyword(s):