scholarly journals THE INFLUENCE OF LECITHIN AND CHOLESTERIN UPON THE GROWTH OF TUMORS

1913 ◽  
Vol 17 (3) ◽  
pp. 344-352 ◽  
Author(s):  
T. Brailsford Robertson ◽  
Theodore C. Burnett
Keyword(s):  
Sodium Oleate ◽  
Primary Tumor ◽  
Chloride Solution ◽  
Strontium Chloride ◽  
Aqueous Emulsion ◽  
Simultaneous Injection ◽  
Primary Growth ◽  
Metastatic Growth

1. Cholesterin, whether suspended in dilute alcohol or in sodium oleate solution, when injected directly into tumors causes a marked acceleration both of the primary and of the metastatic growth. 2. The acceleration of the growth of the primary tumor by cholesterin is most evident in the premetastatic stage. 3. Lecithin, when injected in the form of an aqueous emulsion directly into tumors, diminishes the tendency to form metastases, retards the metastatic growth when it does occur, and in some instances also retards the primary growth. 4. The retardation due to lecithin is most evident in the metastatic stage. 5. Simultaneous injection of M/6 strontium chloride solution into the tumors does not appreciably affect the action of the lecithin.

Molecular dynamics study of an aqueous strontium chloride solution

1988 ◽  
Vol 92 (23) ◽  
pp. 6754-6761 ◽  
Author(s):  
E. Spohr ◽  
G. Palinkas ◽  
K. Heinzinger ◽  
P. Bopp ◽  
M. M. Probst
Keyword(s):  
Molecular Dynamics ◽  
Chloride Solution ◽  
Strontium Chloride

Metastatic Growth of a Murine Tumor: Evidence of Dissemination to the Lungs in the Absence of Subcutaneous Growth

1986 ◽  
Vol 72 (4) ◽  
pp. 345-350 ◽  
Author(s):  
Saverio Alberti ◽  
Stefania Filippeschi ◽  
Federico Spreafico ◽  
Elsa Alberti ◽  
Francesco Colotta
Keyword(s):  
Tumor Growth ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Primary Tumor ◽  
Lung Metastases ◽  
Colon Adenocarcinoma ◽  
Cell Injection ◽  
Metastatic Dissemination ◽  
Metastatic Growth ◽  
Cell Inoculation

Growth of MCA-38/B colon adenocarcinoma was detectable 30-33 days after subcutaneous (s.c.) tumor cell inoculation in mice. Seventy percent of the mice receiving 107 tumor cells, 50 % of those receiving 104, and 15% of the mice given 105 cells developed s.c. tumors (mean of 4 experiments, total of 80 mice per group). Metastases in the presence of a primary tumor were observed in 11% of 107 and in 10% of 106 tumor-cell injected animals. Lung metastases were detected in the absence of tumor growth at the site of s.c. cell injection in 19% of 107, in 8% of 106 and in 5% of 105 and 104 tumor-cell inoculated mice. In parallel experiments an intravenous (i.v.) inoculum of tumor cells produced lung colonies in 40% of 106 and in 14% of 105 tumor-cell injected animals. Smaller inocula did not give rise to lung colonies, thus making it unlikely that accidental i.v. inoculations of tumor cells during the s.c. injections caused the observed metastatic dissemination to the lungs.

Transplantation of male pronucleus derived from in vitro fertilization of enucleated oocyte into parthenogenetically activated oocyte results in live offspring in mouse

Zygote ◽  
2005 ◽  
Vol 13 (1) ◽  
pp. 35-38 ◽  
Author(s):  
Feng-Yun Kong ◽  
Gang Zhang ◽  
Zhi-Sheng Zhong ◽  
Yun-Long Li ◽  
Qing-Yuan Sun ◽  
...  
Keyword(s):  
Chloride Solution ◽  
Cytochalasin B ◽  
Strontium Chloride ◽  
Foster Mother ◽  
Kunming Mouse ◽  
Vitro Fertilization ◽  
Male Pronucleus ◽  
Reconstructed Embryos ◽  
Female Pronucleus

In this study, inter-strain reconstructed embryos were produced by combining the female pronucleus of Kunming mouse (white) with male pronucleus of C57BL/6 strain (black). Metaphase II (MII) oocytes of Kunming mouse were enucleated and the zona pellucida was removed. Then, the enucleated oocytes were inseminated by capacitated sperm of C57BL/6 mouse in vitro. At the same time, MII oocytes of Kunming mouse were artificially activated using strontium chloride solution, which did not contain cytochalasin B. Finally, we removed the male pronucleus derived from C57BL/6 sperm and injected it into a parthenogenetically activated one-pronucleus oocyte by micromanipulation. The reconstructed 2-cell embryos were transplanted into the oviducts of 22 foster mother mice, each receiving about 20 embryos. In the end, seven healthy and live pups were born from one recipient.

scholarly journals Abstract 4264: Mathematical modeling of differential effects of sunitinib on primary tumor and metastatic growth

2018 ◽  
Author(s):  
Chiara Nicolò ◽  
Michalis Mastri ◽  
Amanda Tracz ◽  
John M. Ebos ◽  
Sébastien Benzekry
Keyword(s):  
Mathematical Modeling ◽  
Primary Tumor ◽  
Differential Effects ◽  
Metastatic Growth

Strontium Labelling for Verifying Daily Growth Increments in the Statolith of the Short-Finned Squid (Illex illecebrosus)

1985 ◽  
Vol 42 (2) ◽  
pp. 380-383 ◽  
Author(s):  
Geoffrey V. Hurley ◽  
Paul H. Odense ◽  
Ron K. O'Dor ◽  
Earl G. Dawe
Keyword(s):  
Line Profile ◽  
Electron Microprobe ◽  
Chloride Solution ◽  
Ground Surface ◽  
Strontium Chloride ◽  
Scattered Electron ◽  
Daily Growth ◽  
X Ray ◽  
Distinct Band ◽  
Growth Increments

Shrimp soaked in strontium chloride solution were fed to short-finned squid (Illex illecebrosus). The strontium was deposited in the statolith of the squid where, with the use of an electron microprobe, it was detectable as a distinct band on the ground surface of the statolith. Strontium X-ray maps and corresponding back-scattered electron images in the atomic contrast mode were obtained. Use was made of a strontium X-ray line profile to discriminate between markings deposited only 2 d apart. Micrographs were compared with light micrographs to verify the daily growth increments.

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