Penetration of the blood-brain barrier: enhancement of drug delivery and imaging by bacterial glycopeptides.
1995 ◽
Vol 182
(4)
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pp. 1037-1043
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Keyword(s):
The blood-brain barrier restricts the passage of many pharmacological agents into the brain parenchyma. Bacterial glycopeptides induce enhanced blood-brain barrier permeability when they are present in the subarachnoid space during meningitis. By presenting such glycopeptides intravenously, blood-brain barrier permeability in rabbits was enhanced in a reversible time- and dose-dependent manner to agents < or = 20 kD in size. Therapeutic application of this bioactivity was evident as enhanced penetration of the antibiotic penicillin and the magnetic resonance imaging contrast agent gadolinium-diethylene-triamine-pentaacetic acid into the brain parenchyma.
2018 ◽
Vol 25
(9)
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pp. 1073-1089
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1982 ◽
Vol 16
(4)
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pp. 324-328
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2020 ◽
2015 ◽
Vol 79
(3)
◽
pp. 15
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1993 ◽
Vol 118
(2)
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pp. 188-193
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2003 ◽
Vol 48
(1)
◽
pp. 69-73
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2016 ◽
Vol 105
(2)
◽
pp. 797-807
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1996 ◽
Vol 15
(5)
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pp. 400-405
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