The inter-locus recombinant HLA-B*4601 has high selectivity in peptide binding and functions characteristic of HLA-C.

The vast majority of new human HLA class I alleles are formed by conversions between existing alleles of the same locus. A notable exception to this rule is HLA-B*4601 formed by replacement of residues 66-76 of the alpha 1 helix of B*1501 by the homologous segment of Cw*0102. This inter-locus recombination, which brings together characteristic elements of HLA-B and HLA-C structure, is shown here to influence function dramatically. Naturally processed peptides bound by B*4601 are distinct from those of its parental allotypes B*1501 and Cw*0102 and dominated by three high abundance peptides. Such increased peptide selectivity by B*4601 is unique among HLA-A,B,C allotypes. For other aspects of function, presence of the small segment of HLA-C-derived sequence in an otherwise HLA-B framework converts B*4601 to an HLA-C-like molecule. Alloreactive cytotoxic T lymphocytes (CTL), natural killer (NK) cells, and cellular glycosidases all recognize B*4601 as though it were an HLA-C allotype. These unusual properties are those of an allotype which has frequencies as high as 20% in south east Asian populations and is associated with predisposition to autoimmune diseases and nasopharyngeal carcinoma.

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HLA class I restricted epitopes prediction of common tumor antigens in white and East Asian populations: Implication on antigen selection for cancer vaccine design

PLoS ONE ◽

10.1371/journal.pone.0229327 ◽

2020 ◽

Vol 15 (2) ◽

pp. e0229327

Author(s):

Wei Hu ◽

Meifang He ◽

Liangping Li

Keyword(s):

Cancer Vaccine ◽

Tumor Antigens ◽

East Asian ◽

Vaccine Design ◽

Hla Class I ◽

Class I ◽

Asian Populations ◽

Selection For ◽

Antigen Selection

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1188-P: Glycemic Efficacy of Sitagliptin in East Asian Populations: A Pooled Analysis

Diabetes ◽

10.2337/db19-1188-p ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 1188-P

Author(s):

JOAO M. CONCEICAO ◽

CLAUDIO D. GONZALEZ ◽

SAMUEL S. ENGEL ◽

JONGHO AHN ◽

SHIGERU TOKITA ◽

...

Keyword(s):

East Asian ◽

Pooled Analysis ◽

Asian Populations

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Complications of Asian Double Eyelid Surgery: Prevention and Management

Facial Plastic Surgery ◽

10.1055/s-0040-1717147 ◽

2020 ◽

Vol 36 (05) ◽

pp. 592-601

Author(s):

Stephanie Ming Young ◽

Yoon-Duck Kim

Keyword(s):

East Asian ◽

Eyelid Surgery ◽

Patient Dissatisfaction ◽

Optimal Outcomes ◽

Asian Populations ◽

Underlying Causes ◽

Double Eyelid

AbstractDouble eyelid surgery remains one of the most popular aesthetic surgeries, especially among East Asian populations. Complications related to double eyelid surgery can be divided into various categories: (1) patient dissatisfaction, (2) problems with the eyelid crease, (3) problems with the eyelid height, (4) suture-related complications, and (5) complications related to eyelid surgery in general. As with all eyelid surgeries, it is important to understand and appreciate the normal and abnormal function and anatomy of the Asian eyelid to reduce the risk of complications. It is also important to recognize the various complications and their underlying causes so that the surgeon can confidently revise the surgery to achieve optimal outcomes.

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Efficacy Comparison for a Schizophrenia and a Dysuria Drug Among East Asian Populations: A Retrospective Analysis Using Multi-regional Clinical Trial Data

Therapeutic Innovation & Regulatory Science ◽

10.1007/s43441-020-00246-9 ◽

2021 ◽

Author(s):

Kimie Sai ◽

Eiji Nakatani ◽

Yasuhiro Iwama ◽

Shuichi Hiraoka ◽

Masahiro Tohkin ◽

...

Keyword(s):

Clinical Trial ◽

Retrospective Analysis ◽

East Asian ◽

Clinical Trial Data ◽

Trial Data ◽

Asian Populations

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The molecular basis of how buried human leukocyte antigen polymorphism modulates natural killer cell function

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1920570117 ◽

2020 ◽

Vol 117 (21) ◽

pp. 11636-11647 ◽

Cited By ~ 1

Author(s):

Philippa M. Saunders ◽

Bruce J. MacLachlan ◽

Phillip Pymm ◽

Patricia T. Illing ◽

Yuanchen Deng ◽

...

Keyword(s):

Human Leukocyte Antigen ◽

Natural Killer ◽

Nk Cell ◽

Killer Cell ◽

Peptide Binding ◽

Human Leukocyte ◽

Hla Class I ◽

Cell Recognition ◽

Leukocyte Antigen ◽

Binding Cleft

Micropolymorphisms within human leukocyte antigen (HLA) class I molecules can change the architecture of the peptide-binding cleft, leading to differences in peptide presentation and T cell recognition. The impact of such HLA variation on natural killer (NK) cell recognition remains unclear. Given the differential association of HLA-B*57:01 and HLA-B*57:03 with the control of HIV, recognition of these HLA-B57 allomorphs by the killer cell immunoglobulin-like receptor (KIR) 3DL1 was compared. Despite differing by only two polymorphic residues, both buried within the peptide-binding cleft, HLA-B*57:01 more potently inhibited NK cell activation. Direct-binding studies showed KIR3DL1 to preferentially recognize HLA-B*57:01, particularly when presenting peptides with positively charged position (P)Ω-2 residues. In HLA-B*57:01, charged PΩ-2 residues were oriented toward the peptide-binding cleft and away from KIR3DL1. In HLA-B*57:03, the charged PΩ-2 residues protruded out from the cleft and directly impacted KIR3DL1 engagement. Accordingly, KIR3DL1 recognition of HLA class I ligands is modulated by both the peptide sequence and conformation, as determined by the HLA polymorphic framework, providing a rationale for understanding differences in clinical associations.

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