scholarly journals p53 connects tumorigenesis and reprogramming to pluripotency

2010 ◽  
Vol 207 (10) ◽  
pp. 2045-2048 ◽  
Author(s):  
Natalia Tapia ◽  
Hans R. Schöler
Keyword(s):  
Cell Cycle ◽  
Dna Repair ◽  
Tumor Suppressor ◽  
Cell Cycle Arrest ◽  
Suppressor Gene ◽  
Tumor Formation ◽  
Nuclear Reprogramming ◽  
Differentiation Process ◽  
Cycle Arrest ◽  
Tumor Suppressor Gene P53

The tumor suppressor gene p53 prevents the initiation of tumor formation by inducing cell cycle arrest, senescence, DNA repair, and apoptosis. Recently, the absence or mutation of p53 was described to facilitate nuclear reprogramming. These findings suggest an influence of p53 on the de-differentiation process, and highlight the similarities between induction of pluripotency and tumor formation.

scholarly journals DC-SCRIPT is a novel regulator of the tumor suppressor gene CDKN2B and induces cell cycle arrest in ERα-positive breast cancer cells

2015 ◽  
Vol 149 (3) ◽  
pp. 693-703 ◽  
Author(s):  
Marleen Ansems ◽  
Jonas Nørskov Søndergaard ◽  
Anieta M. Sieuwerts ◽  
Maaike W. G. Looman ◽  
Marcel Smid ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Tumor Suppressor ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Tumor Suppressor Gene ◽  
Breast Cancer Cells ◽  
Suppressor Gene ◽  
Cycle Arrest ◽  
Positive Breast Cancer

scholarly journals 3p21.3 Tumor Suppressor Gene H37/Luca15/RBM5 Inhibits Growth of Human Lung Cancer Cells through Cell Cycle Arrest and Apoptosis

2006 ◽  
Vol 66 (7) ◽  
pp. 3419-3427 ◽  
Author(s):  
Juliana J. Oh ◽  
Ali Razfar ◽  
Idolina Delgado ◽  
Rebecca A. Reed ◽  
Anna Malkina ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Cycle ◽  
Tumor Suppressor ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Human Lung ◽  
Suppressor Gene ◽  
Human Lung Cancer ◽  
Cycle Arrest ◽  
Human Lung Cancer Cells

scholarly journals Recent Advances in p53

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 211
Author(s):  
Gabriella D’Orazi
Keyword(s):  
Cell Cycle ◽  
Dna Repair ◽  
Transcription Factor ◽  
Tumor Suppressor ◽  
Cell Cycle Arrest ◽  
Tumor Suppressor Protein ◽  
Cellular Functions ◽  
Tumor Suppressor Protein P53 ◽  
Cycle Arrest ◽  
Stress Signals

Tumor suppressor protein p53 (TP53) is a key transcription factor that, in response to various stress signals, regulates numerous genes involved in a broad range of cellular functions including DNA repair, apoptosis, cell cycle arrest, senescence, metabolism, etc [...]

scholarly journals BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer

2009 ◽  
Vol 30 (4) ◽  
pp. 662-670 ◽  
Author(s):  
S. Majid ◽  
A. A. Dar ◽  
A. E. Ahmad ◽  
H. Hirata ◽  
K. Kawakami ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Suppressor ◽  
Histone Modification ◽  
Cell Cycle Arrest ◽  
Tumor Suppressor Gene ◽  
Renal Cancer ◽  
Gene Promoter ◽  
Suppressor Gene ◽  
Cycle Arrest

scholarly journals Role of Mis Localization of DNA Repair Factors in Cell Cycle Arrest

2019 ◽  
Vol 116 (3) ◽  
pp. 76a
Author(s):  
Manasvita Vashisth ◽  
Sangkyun Cho ◽  
Dennis Discher
Keyword(s):  
Cell Cycle ◽  
Dna Repair ◽  
Cell Cycle Arrest ◽  
Cycle Arrest
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