scholarly journals Siamon Gordon: A half-century fascination with macrophages

2020 ◽  
Vol 217 (7) ◽  
Author(s):  
Stephanie Houston

Siamon Gordon is a Glaxo Wellcome Professor Emeritus of Cellular Pathology at the University of Oxford and a fellow of the Royal Society. Throughout his career, Siamon has focused on macrophages, and his work led to the identification of the pan-macrophage marker F4/80 and the description of a role for Dectin-1 in the innate recognition of β-glucans. I caught up with Siamon to discuss his career path and his thoughts on macrophages.

1806 ◽  
Vol 96 ◽  
pp. 305-326 ◽  

Dear Sir, Being perfectly convinced of your love of mathematical science, and your extensive acquirements in it, I submit to your perusal a new demonstration of the binomial theorem, when the exponent is a positive or negative fraction. As I am a strenuous advocate for smoothing the way to the acquisition of useful knowledge, i deem the following articles of some importance ; and unless I were equally sincere in this persuasion, and in that of your desire to promote mathemati­cal studies, in requesting the perusal, I should accuse myself of an attempt to trifle with your valuable time. The following demonstration is new only to the extent above mentioned ; but in order that the reader may perceive the proof to be complete, a successive perusal of all the articles is necessary. As far as it relates to the raising of in­tegral powers, it is in substance the same with one which I drew up in the year 1794, and which was honoured with a place in the Philosophical Transactions for 1795. If, therefore, you think the following demonstration worthy the attention of mathematicians, you will much oblige me by presenting it to the Royal Society.


1761 ◽  
Vol 52 ◽  
pp. 173-177 ◽  

My Lord, The present bad state of health of my worthy friend and collegue Dr. Bradley, his Majesty's Astronomer, prevented him from making the proper observations of the transit of Venus on Saturday morning last; and consequently, has deprived the public of such as would have been taken by so experienced and accurate an observer.


In the year 1782, while Sir Joseph Banks, the autocrat of the philosophers, who presided so formidably over the Royal Society for no less than forty-three years, was still comparatively new to office, the extraordinary conduct of a learned and popular Fellow involved the Royal Society in a situation of some difficulty. James Price was not only wealthy and of high social standing, he was also a man of considerable reputation as a chemist. In May of the year before, he had been elected to the Society with complete confidence. In the spring of 1782, to the consternation of his fellow chemists, this man whom they held to be not only an authority on chemistry but a man of honour put forward a claim to have achieved the goal towards which throughout the ages the efforts of the alchemists had been directed. He had discovered, he said, a means of transmuting baser metal into gold. He claimed to be in possession of a white powder, capable of converting fifty times its own weight of mercury into silver and a red powder which could convert sixty times its weight of mercury into gold. Between 7 May and 25 May 1782 he conducted in public in the laboratory in his house at Stoke, near Guildford, a series of experiments which appeared to his audience to confirm his claim in every respect. The demonstrations were attended by a distinguished company, including his neighbours Lord Onslow, Lord King and Lord Palmerston, although, as the Royal Society could not but feel, it was not a scientific audience nor one qualified to pass judgement on his claim. The apparent success of his experiments caused an immense sensation and the belief in his powers was strengthened when the gold and silver alleged to have been produced were found genuine on assay and were exhibited to the King. The University of Oxford—Price had been a Fellow-commoner of Oriel—presented him with the degree of M.D. on account of* his chemical labours ’, and two editions of his book,1 describing in great detail the chemical reactions concerned in the process, were quickly sold.


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